TPP2 - tripeptidyl peptidase 2 Gene

Homo sapiens

Also known as IMD78; TPP-2; TPPII; TPP-II

Gene ID: 7174 | Gene type: protein coding

About TPP2

Cytogenetic location: 13q33.1 Genomic coordinates (GRCh38): 13:102,596,986-102,679,958 (from NCBI)

This gene has 29 transcripts (splice variants), 196 orthologues, 9 paralogues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 27.4), thyroid (RPKM 15.8) and 25 other tissues.

Summary

This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer Peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]

TPP2 Products(3)

mRNA	Protein	Name
NM_001330588.2	NP_001317517.1	tripeptidyl-peptidase 2 isoform 2
NM_001367947.1	NP_001354876.1	tripeptidyl-peptidase 2 isoform 3
NM_003291.4	NP_003282.2	tripeptidyl-peptidase 2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables aminopeptidase activity	EXP EXP: Inferred from Experiment	9668046	GOA
enables aminopeptidase activity	IMP IMP: Inferred from mutant phenotype	25525876	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	22483107	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in intracellular amino acid homeostasis	IMP IMP: Inferred from mutant phenotype	25525876	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TPP2 Protein Structure

Peptidase_S8

TPPII

0
200
400
600
800
1000
1249 a.a.

Protein Preferred Names

Protein Names

tripeptidyl-peptidase 2

tripeptidyl aminopeptidase

TPP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TPP2	P29144	POLB	Homo sapiens	P06746	Y2H Array	25416956
Intra	TPP2	P29144	EHHADH	Homo sapiens	Q08426	Y2H Array	31515488
Intra	TPP2	P29144	EHHADH	Homo sapiens	Q08426	Y2H Prey Pooling	25416956
Intra	TPP2	P29144	POLB	Homo sapiens	P06746	Y2H Prey Pooling	25416956
Intra	TPP2	P29144	EHHADH	Homo sapiens	Q08426	Validated Y2H	25416956
Intra	TPP2	P29144	PPP1R16A	Homo sapiens	Q96I34	Y2H Array	25416956
Intra	TPP2	P29144	EHHADH	Homo sapiens	Q08426	Y2H Array	25416956
Intra	TPP2	P29144	POLB	Homo sapiens	P06746	Y2H Array	31515488

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TPP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71451	TPP2 Protein, Human (Myc, His)	P29144 (44D-264H)	≥95%

Related Diseases

Diseases

Alias

Immunodeficiency 78 With Autoimmunity And Developmental Delay

IMD78	Tpp2 Deficiency
Autoimmune Hemolytic Anemia-Autoimmune Thrombocytopenia-Primary Immunodeficiency Syndrome	Evans Syndrome Associated With Primary Immunodeficiency
Tppii Deficiency	Tppii-Related Immunodeficiency, Autoimmunity, And Neurodevelopmental Delay With Impaired Glycolysis And Lysosomal Expansion Disease
Triangle Disease	Tripeptidyl-Peptidase Ii Deficiency

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Evans' Syndrome

Evans Syndrome	Autoimmune Hemolytic Anemia And Autoimmune Thrombocytopenia
Evan Syndrome	Immune Pancytopenia
Evan'S Syndrome

Herpetic Whitlow

Herpetic Felon

Hemolytic Anemia

Anemia, Hemolytic	Anemia Hemolytic
Anaemia Due To Other Disorders Of Glutathione Metabolism	Chronic Non Spherocytic Anaemia
G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia	Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency
Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia	Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia
Favism Anaemia	Haemolytic Anaemia Due Tog6pd Deficiency
Favism	Pentose Phosphate Pathway Disorder Anaemia
Anaemia Due To Pentose Phosphate Pathway Defect

Ras-Associated Autoimmune Leukoproliferative Disorder

RALD	Autoimmune Lymphoproliferative Syndrome Type 4
Alps4	Autoimmune Lymphoproliferative Syndrome, Type Iv
Ras-Associated Autoimmune Leukoproliferative Disease	Ras-Associated Autoimmune Lymphoproliferative Syndrome Type Iv, Somatic
Alps Type 4	Alps Type Iv
Autoimmune Lymphoproliferative Syndrome Type Iv	Autoimmune Lymphoproliferative Syndrome 4

Epidermodysplasia Verruciformis 1

Epidermodysplasia Verruciformis	Epidermodysplasia Verruciformis, Susceptibility To, 1
Lutz-Lewandowsky Epidermodysplasia Verruciformis	EV1
Lewandowsky-Lutz Syndrome	Ev

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14943	TPP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TPP2	VGNC	VGNC:47748
Felis catus	TPP2	VGNC	VGNC:66481
Mus musculus	TPP2	MGD	MGI:102724
Bos taurus	TPP2	VGNC	VGNC:36257
Macaca mulatta	TPP2	VGNC	VGNC:78637
Rattus norvegicus	TPP2	RGD	RGD:621584
Others	TPP2	NCBI

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