EHHADH - enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase Gene

Homo sapiens

Also known as LBP; ECHD; LBFP; MFE1; PBFE; FRTS3; L-PBE

Gene ID: 1962 | Gene type: protein coding

About EHHADH

Cytogenetic location: 3q27.2 Genomic coordinates (GRCh38): 3:185,190,624-185,254,049 (from NCBI)

This gene has 6 transcripts (splice variants), 204 orthologues, 3 paralogues and is associated with 3 phenotypes. Biased expression in liver (RPKM 75.1), kidney (RPKM 65.6) and 8 other tissues.

Summary

The protein encoded by this gene is a bifunctional Enzyme and is one of the four Enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of the encoded protein contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in this gene are a cause of peroxisomal disorders such as Zellweger syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

EHHADH Products(2)

mRNA	Protein	Name
NM_001166415.2	NP_001159887.1	peroxisomal bifunctional enzyme isoform 2
NM_001966.4	NP_001957.2	peroxisomal bifunctional enzyme isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3-hydroxyacyl-CoA dehydrogenase activity	IDA IDA: Inferred from direct assay	15060085	GOA
enables enoyl-CoA hydratase activity	IDA IDA: Inferred from direct assay	15060085	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	16781659	GOA
enables long-chain-3-hydroxyacyl-CoA dehydrogenase activity	IDA IDA: Inferred from direct assay	15060085	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in fatty acid beta-oxidation	IDA IDA: Inferred from direct assay	15060085	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in peroxisome	IDA IDA: Inferred from direct assay	1651711	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EHHADH Protein Structure

ECH_1

3HCDH_N

3HCDH

0
200
400
600
723 a.a.

Protein Preferred Names

Protein Names

peroxisomal bifunctional enzyme

3,2-trans-enoyl-CoA isomerase

EHHADH Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EHHADH	Q08426	PNMA5	Homo sapiens	Q96PV4	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	PNMA5	Homo sapiens	Q96PV4	Validated Y2H	32296183
Intra	EHHADH	Q08426	PNMA5	Homo sapiens	Q96PV4	Y2H Array	32296183
Intra	EHHADH	Q08426	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	EHHADH	Q08426	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	EHHADH	Q08426	MAB21L3	Homo sapiens	Q8N8X9	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	MAB21L3	Homo sapiens	Q8N8X9	Validated Y2H	32296183
Intra	EHHADH	Q08426	MAB21L3	Homo sapiens	Q8N8X9	Y2H Array	32296183
Intra	EHHADH	Q08426	CYB561A3	Homo sapiens	Q8NBI2	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	CYB561A3	Homo sapiens	Q8NBI2	Validated Y2H	32296183
Intra	EHHADH	Q08426	CYB561A3	Homo sapiens	Q8NBI2	Y2H Array	32296183
Intra	EHHADH	Q08426	KRTAP4-11	Homo sapiens	Q9BYQ6	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	KRTAP4-11	Homo sapiens	Q9BYQ6	Validated Y2H	32296183
Intra	EHHADH	Q08426	KRTAP4-11	Homo sapiens	Q9BYQ6	Y2H Array	32296183
Intra	EHHADH	Q08426	TPP2	Homo sapiens	P29144	Y2H Array	31515488
Intra	EHHADH	Q08426	CISD2	Homo sapiens	Q8N5K1	Validated Y2H	32296183
Intra	EHHADH	Q08426	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
Intra	EHHADH	Q08426	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	PSTPIP1	Homo sapiens	O43586	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	PSTPIP1	Homo sapiens	O43586	Y2H Array	32296183
Intra	EHHADH	Q08426	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	HSD17B11	Homo sapiens	Q8NBQ5	Validated Y2H	32296183
Intra	EHHADH	Q08426	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Array	32296183
Intra	EHHADH	Q08426	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	EHHADH	Q08426	RPRM	Homo sapiens	Q9NS64	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	RPRM	Homo sapiens	Q9NS64	Y2H Array	32296183
Intra	EHHADH	Q08426	GAS8	Homo sapiens	O95995	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	GAS8	Homo sapiens	O95995	Y2H Array	32296183
Intra	EHHADH	Q08426	CMTM6	Homo sapiens	Q9NX76	Y2H Array	32296183
Intra	EHHADH	Q08426	CMTM6	Homo sapiens	Q9NX76	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	CMTM6	Homo sapiens	Q9NX76	Validated Y2H	32296183
Intra	EHHADH	Q08426	ORMDL1	Homo sapiens	Q9P0S3	Y2H Array	32296183
Intra	EHHADH	Q08426	ORMDL1	Homo sapiens	Q9P0S3	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	ORMDL1	Homo sapiens	Q9P0S3	Validated Y2H	32296183
Intra	EHHADH	Q08426	DES	Homo sapiens	P17661	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	DES	Homo sapiens	P17661	Y2H Array	32296183
Intra	EHHADH	Q08426	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	EHHADH	Q08426	CCDC13	Homo sapiens	Q8IYE1	Validated Y2H	32296183
Intra	EHHADH	Q08426	CCDC13	Homo sapiens	Q8IYE1	Y2H Array	32296183
Intra	EHHADH	Q08426	CCDC13	Homo sapiens	Q8IYE1	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	CDR2L	Homo sapiens	Q86X02	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	CDR2L	Homo sapiens	Q86X02	Validated Y2H	32296183
Intra	EHHADH	Q08426	CDR2L	Homo sapiens	Q86X02	Y2H Array	32296183
Intra	EHHADH	Q08426	CEP83	Homo sapiens	Q9Y592-2	Validated Y2H	32296183
Intra	EHHADH	Q08426	CEP83	Homo sapiens	Q9Y592-2	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	CEP83	Homo sapiens	Q9Y592-2	Y2H Array	32296183
Intra	EHHADH	Q08426	PTGES	Homo sapiens	O14684	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	SYNGR3	Homo sapiens	O43761	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	SYNGR3	Homo sapiens	O43761	Y2H Array	32296183
Intra	EHHADH	Q08426	TMEM17	Homo sapiens	Q86X19	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	TMEM17	Homo sapiens	Q86X19	Validated Y2H	32296183
Intra	EHHADH	Q08426	TMEM17	Homo sapiens	Q86X19	Y2H Array	32296183
Intra	EHHADH	Q08426	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	32296183
Intra	EHHADH	Q08426	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	EHHADH	Q08426	UBXN1	Homo sapiens	Q04323-2	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	UBXN1	Homo sapiens	Q04323-2	Y2H Array	32296183
Intra	EHHADH	Q08426	CAPN3	Homo sapiens	P20807-4	Y2H Array	32296183
Intra	EHHADH	Q08426	CAPN3	Homo sapiens	P20807-4	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	TMEM35A	Homo sapiens	Q53FP2	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	TMEM35A	Homo sapiens	Q53FP2	Validated Y2H	32296183
Intra	EHHADH	Q08426	TMEM35A	Homo sapiens	Q53FP2	Y2H Array	32296183
Intra	EHHADH	Q08426	LCN2	Homo sapiens	P80188	Y2H Array	32296183
Intra	EHHADH	Q08426	LCN2	Homo sapiens	P80188	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	BOLL	Homo sapiens	Q8N9W6-4	Validated Y2H	32296183
Intra	EHHADH	Q08426	BOLL	Homo sapiens	Q8N9W6-4	Y2H Array	32296183
Intra	EHHADH	Q08426	BOLL	Homo sapiens	Q8N9W6-4	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	ADARB1	Homo sapiens	P78563-4	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	ADARB1	Homo sapiens	P78563-4	Y2H Array	32296183
Intra	EHHADH	Q08426	ZBTB10	Homo sapiens	Q96DT7-3	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	ZBTB10	Homo sapiens	Q96DT7-3	Validated Y2H	32296183
Intra	EHHADH	Q08426	ZBTB10	Homo sapiens	Q96DT7-3	Y2H Array	32296183
Intra	EHHADH	Q08426	TMEM121	Homo sapiens	Q9BTD3	Validated Y2H	32296183
Intra	EHHADH	Q08426	TMEM121	Homo sapiens	Q9BTD3	Y2H Array	32296183
Intra	EHHADH	Q08426	TMEM121	Homo sapiens	Q9BTD3	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	ANKRD36B	Homo sapiens	Q8N2N9-4	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	ANKRD36B	Homo sapiens	Q8N2N9-4	Validated Y2H	32296183
Intra	EHHADH	Q08426	ANKRD36B	Homo sapiens	Q8N2N9-4	Y2H Array	32296183
Intra	EHHADH	Q08426	SYNGR1	Homo sapiens	O43759-2	Y2H Array	32296183
Intra	EHHADH	Q08426	SYNGR1	Homo sapiens	O43759-2	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	SMIM5	Homo sapiens	Q71RC9	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	SMIM5	Homo sapiens	Q71RC9	Validated Y2H	32296183
Intra	EHHADH	Q08426	SMIM5	Homo sapiens	Q71RC9	Y2H Array	32296183
Intra	EHHADH	Q08426	OPRM1	Homo sapiens	P35372-10	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	OPRM1	Homo sapiens	P35372-10	Y2H Array	32296183
Intra	EHHADH	Q08426	SCARA5	Homo sapiens	Q6ZMJ2-2	Validated Y2H	32296183
Intra	EHHADH	Q08426	SCARA5	Homo sapiens	Q6ZMJ2-2	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	SCARA5	Homo sapiens	Q6ZMJ2-2	Y2H Array	32296183
Intra	EHHADH	Q08426	DERL3	Homo sapiens	Q96Q80	Validated Y2H	32296183
Intra	EHHADH	Q08426	DERL3	Homo sapiens	Q96Q80	Y2H Array	32296183
Intra	EHHADH	Q08426	FGF14	Homo sapiens	Q92915-2	Y2H Array	32296183
Intra	EHHADH	Q08426	FGF14	Homo sapiens	Q92915-2	Validated Y2H	32296183
Intra	EHHADH	Q08426	FGF14	Homo sapiens	Q92915-2	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	TRIM5	Homo sapiens	Q9C035-3	Validated Y2H	32296183
Intra	EHHADH	Q08426	TRIM5	Homo sapiens	Q9C035-3	Y2H Array	32296183
Intra	EHHADH	Q08426	TRIM5	Homo sapiens	Q9C035-3	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	PAQR8	Homo sapiens	Q8TEZ7	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	PAQR8	Homo sapiens	Q8TEZ7	Validated Y2H	32296183
Intra	EHHADH	Q08426	PAQR8	Homo sapiens	Q8TEZ7	Y2H Array	32296183
Intra	EHHADH	Q08426	SLC39A2	Homo sapiens	Q9NP94	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	SLC39A2	Homo sapiens	Q9NP94	Validated Y2H	32296183
Intra	EHHADH	Q08426	SLC39A2	Homo sapiens	Q9NP94	Y2H Array	32296183
Intra	EHHADH	Q08426	HTATIP2	Homo sapiens	Q9BUP3-3	Y2H Array	32296183
Intra	EHHADH	Q08426	HTATIP2	Homo sapiens	Q9BUP3-3	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	HTATIP2	Homo sapiens	Q9BUP3-3	Validated Y2H	32296183
Intra	EHHADH	Q08426	REEP6	Homo sapiens	Q96HR9-2	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	REEP6	Homo sapiens	Q96HR9-2	Validated Y2H	32296183
Intra	EHHADH	Q08426	REEP6	Homo sapiens	Q96HR9-2	Y2H Array	32296183
Intra	EHHADH	Q08426	SLC14A2	Homo sapiens	Q15849	Validated Y2H	32296183
Intra	EHHADH	Q08426	SLC14A2	Homo sapiens	Q15849	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	SLC14A2	Homo sapiens	Q15849	Y2H Array	32296183
Intra	EHHADH	Q08426	CLDN18	Homo sapiens	P56856	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	CLDN18	Homo sapiens	P56856	Y2H Array	32296183
Intra	EHHADH	Q08426	LYPD5	Homo sapiens	Q6UWN5	Y2H Array	32296183
Intra	EHHADH	Q08426	LYPD5	Homo sapiens	Q6UWN5	Validated Y2H	32296183
Intra	EHHADH	Q08426	LYPD5	Homo sapiens	Q6UWN5	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
Intra	EHHADH	Q08426	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	EHHADH	Q08426	ERVFRD-1	Homo sapiens	P60508	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	ERVFRD-1	Homo sapiens	P60508	Y2H Array	32296183
Intra	EHHADH	Q08426	CLDN5	Homo sapiens	O00501	Y2H Array	32296183
Intra	EHHADH	Q08426	CLDN5	Homo sapiens	O00501	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	VAC14	Homo sapiens	Q08AM6	Y2H Array	32296183
Intra	EHHADH	Q08426	VAC14	Homo sapiens	Q08AM6	Validated Y2H	32296183
Intra	EHHADH	Q08426	VAC14	Homo sapiens	Q08AM6	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	25416956
Intra	EHHADH	Q08426	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	25416956
Intra	EHHADH	Q08426	SSX2IP	Homo sapiens	Q9Y2D8	Validated Y2H	25416956
Intra	EHHADH	Q08426	MID1	Homo sapiens	O15344	Y2H Array	31515488
Intra	EHHADH	Q08426	MID1	Homo sapiens	O15344	Validated Y2H	25416956
Intra	EHHADH	Q08426	MID1	Homo sapiens	O15344	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	MID1	Homo sapiens	O15344	Y2H Array	25416956
Intra	EHHADH	Q08426	MID1	Homo sapiens	O15344	Y2H Array	32296183
Intra	EHHADH	Q08426	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Intra	EHHADH	Q08426	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	KCTD6	Homo sapiens	Q8NC69	Y2H Array	25416956
Intra	EHHADH	Q08426	KCTD6	Homo sapiens	Q8NC69	Y2H Array	31515488
Intra	EHHADH	Q08426	SSNA1	Homo sapiens	O43805	Y2H Array	25416956
Intra	EHHADH	Q08426	SSNA1	Homo sapiens	O43805	Validated Y2H	25416956
Intra	EHHADH	Q08426	GMCL1	Homo sapiens	Q96IK5	Validated Y2H	32296183
Intra	EHHADH	Q08426	GMCL1	Homo sapiens	Q96IK5	Y2H Array	32296183
Intra	EHHADH	Q08426	GMCL1	Homo sapiens	Q96IK5	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	LZTFL1	Homo sapiens	Q9NQ48	Y2H Array	32296183
Intra	EHHADH	Q08426	LZTFL1	Homo sapiens	Q9NQ48	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	LZTFL1	Homo sapiens	Q9NQ48	Validated Y2H	32296183
Intra	EHHADH	Q08426	SFT2D1	Homo sapiens	Q8WV19	Y2H Array	32296183
Intra	EHHADH	Q08426	SFT2D1	Homo sapiens	Q8WV19	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	SFT2D1	Homo sapiens	Q8WV19	Validated Y2H	32296183
Intra	EHHADH	Q08426	C1orf50	Homo sapiens	Q9BV19	Validated Y2H	32296183
Intra	EHHADH	Q08426	C1orf50	Homo sapiens	Q9BV19	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	C1orf50	Homo sapiens	Q9BV19	Y2H Array	32296183
Intra	EHHADH	Q08426	PNMA1	Homo sapiens	Q8ND90	Y2H Array	25416956
Intra	EHHADH	Q08426	FUNDC1	Homo sapiens	Q8IVP5	Validated Y2H	25416956
Intra	EHHADH	Q08426	AARS2	Homo sapiens	Q5JTZ9	Validated Y2H	32296183
Intra	EHHADH	Q08426	AARS2	Homo sapiens	Q5JTZ9	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	AARS2	Homo sapiens	Q5JTZ9	Y2H Array	32296183
Intra	EHHADH	Q08426	LTBR	Homo sapiens	P36941	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	LTBR	Homo sapiens	P36941	Y2H Array	32296183
Intra	EHHADH	Q08426	PRMT5	Homo sapiens	O14744	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	PRMT5	Homo sapiens	O14744	Y2H Array	32296183
Intra	EHHADH	Q08426	CFL2	Homo sapiens	Q9Y281	Y2H Array	32296183
Intra	EHHADH	Q08426	CFL2	Homo sapiens	Q9Y281	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	CFL2	Homo sapiens	Q9Y281	Validated Y2H	32296183
Intra	EHHADH	Q08426	ACTG1	Homo sapiens	P63261	Validated Y2H	25416956
Intra	EHHADH	Q08426	ACTG1	Homo sapiens	P63261	Y2H Array	25416956
Intra	EHHADH	Q08426	ACTG1	Homo sapiens	P63261	Y2H Prey Pooling	25416956
Intra	EHHADH	Q08426	ACTB	Homo sapiens	P60709	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	ACTB	Homo sapiens	P60709	Y2H Array	32296183
Intra	EHHADH	Q08426	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	TRAF2	Homo sapiens	Q12933	Validated Y2H	32296183
Intra	EHHADH	Q08426	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	EHHADH	Q08426	TNIP1	Homo sapiens	Q15025	Validated Y2H	25416956
Intra	EHHADH	Q08426	TNIP1	Homo sapiens	Q15025	Y2H Prey Pooling	25416956
Intra	EHHADH	Q08426	TRAF1	Homo sapiens	Q13077	Validated Y2H	25416956
Intra	EHHADH	Q08426	TRAF1	Homo sapiens	Q13077	Y2H Array	25416956
Intra	EHHADH	Q08426	ARMC12	Homo sapiens	Q5T9G4-2	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	ARMC12	Homo sapiens	Q5T9G4-2	Validated Y2H	32296183
Intra	EHHADH	Q08426	ARMC12	Homo sapiens	Q5T9G4-2	Y2H Array	32296183
Intra	EHHADH	Q08426	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	EBP	Homo sapiens	Q15125	Validated Y2H	32296183
Intra	EHHADH	Q08426	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	EHHADH	Q08426	ZBTB26	Homo sapiens	Q9HCK0	Validated Y2H	32296183
Intra	EHHADH	Q08426	ZBTB26	Homo sapiens	Q9HCK0	Y2H Array	32296183
Intra	EHHADH	Q08426	ZBTB26	Homo sapiens	Q9HCK0	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	SDR16C5	Homo sapiens	Q8N3Y7	Validated Y2H	32296183
Intra	EHHADH	Q08426	SDR16C5	Homo sapiens	Q8N3Y7	Y2H Array	32296183
Intra	EHHADH	Q08426	SDR16C5	Homo sapiens	Q8N3Y7	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	SMN1	Homo sapiens	Q16637	Y2H Array	32296183
Intra	EHHADH	Q08426	SMN1	Homo sapiens	Q16637	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	SMN1	Homo sapiens	Q16637	Validated Y2H	32296183
Intra	EHHADH	Q08426	ZBTB9	Homo sapiens	Q96C00	Validated Y2H	32296183
Intra	EHHADH	Q08426	ZBTB9	Homo sapiens	Q96C00	Y2H Prey Pooling	25416956
Intra	EHHADH	Q08426	ZBTB9	Homo sapiens	Q96C00	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	ZBTB9	Homo sapiens	Q96C00	Y2H Array	32296183
Intra	EHHADH	Q08426	EMP1	Homo sapiens	P54849	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	EMP1	Homo sapiens	P54849	Y2H Array	32296183
Intra	EHHADH	Q08426	KCTD9	Homo sapiens	Q7L273	Y2H Prey Pooling	25416956
Intra	EHHADH	Q08426	HIP1	Homo sapiens	O00291	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	HIP1	Homo sapiens	O00291	Y2H Array	32296183
Intra	EHHADH	Q08426	DIABLO	Homo sapiens	Q9NR28	Validated Y2H	32296183
Intra	EHHADH	Q08426	DIABLO	Homo sapiens	Q9NR28	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	DIABLO	Homo sapiens	Q9NR28	Y2H Array	32296183
Intra	EHHADH	Q08426	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	EHHADH	Q08426	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	EHHADH	Q08426	TRIM63	Homo sapiens	Q969Q1	Y2H Array	32296183
Intra	EHHADH	Q08426	TRIM63	Homo sapiens	Q969Q1	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	TRIM63	Homo sapiens	Q969Q1	Validated Y2H	32296183
Intra	EHHADH	Q08426	SGCB	Homo sapiens	Q16585	Validated Y2H	32296183
Intra	EHHADH	Q08426	SGCB	Homo sapiens	Q16585	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	SGCB	Homo sapiens	Q16585	Y2H Array	32296183
Intra	EHHADH	Q08426	BHLHE40	Homo sapiens	O14503	Y2H Prey Pooling	25416956
Intra	EHHADH	Q08426	BHLHE40	Homo sapiens	O14503	Validated Y2H	25416956
Intra	EHHADH	Q08426	BHLHE40	Homo sapiens	O14503	Y2H Array	25416956
Intra	EHHADH	Q08426	PRKRA	Homo sapiens	O75569	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	PRKRA	Homo sapiens	O75569	Y2H Array	32296183
Intra	EHHADH	Q08426	ARMCX3	Homo sapiens	Q9UH62	Y2H Array	32296183
Intra	EHHADH	Q08426	ARMCX3	Homo sapiens	Q9UH62	Validated Y2H	32296183
Intra	EHHADH	Q08426	ARMCX3	Homo sapiens	Q9UH62	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	GRIPAP1	Homo sapiens	Q4V328	Validated Y2H	32296183
Intra	EHHADH	Q08426	GRIPAP1	Homo sapiens	Q4V328	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	GRIPAP1	Homo sapiens	Q4V328	Y2H Array	32296183
Intra	EHHADH	Q08426	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	EHHADH	Q08426	PPP1R12C	Homo sapiens	Q9BZL4	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	PPP1R12C	Homo sapiens	Q9BZL4	Validated Y2H	32296183
Intra	EHHADH	Q08426	PPP1R12C	Homo sapiens	Q9BZL4	Y2H Array	32296183
Intra	EHHADH	Q08426	COQ9	Homo sapiens	O75208	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	COQ9	Homo sapiens	O75208	Y2H Array	32296183
Intra	EHHADH	Q08426	TRIM41	Homo sapiens	Q8WV44	Validated Y2H	32296183
Intra	EHHADH	Q08426	TRIM41	Homo sapiens	Q8WV44	Y2H Array	32296183
Intra	EHHADH	Q08426	TRIM41	Homo sapiens	Q8WV44	Anti Tag CoIP	33961781
Intra	EHHADH	Q08426	TRIM41	Homo sapiens	Q8WV44	Y2H Prey Pooling	25416956
Intra	EHHADH	Q08426	TRIM41	Homo sapiens	Q8WV44	Validated Y2H	25416956
Intra	EHHADH	Q08426	TRIM41	Homo sapiens	Q8WV44	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	TRIM23	Homo sapiens	P36406	Y2H Array	32296183
Intra	EHHADH	Q08426	CBS	Homo sapiens	P35520	Validated Y2H	25416956
Intra	EHHADH	Q08426	CBS	Homo sapiens	P35520	Y2H Array	31515488
Intra	EHHADH	Q08426	CBS	Homo sapiens	P35520	Y2H Prey Pooling	25416956
Intra	EHHADH	Q08426	HMG20A	Homo sapiens	Q9NP66	Y2H Array	32296183
Intra	EHHADH	Q08426	HMG20A	Homo sapiens	Q9NP66	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	HMG20A	Homo sapiens	Q9NP66	Validated Y2H	32296183
Intra	EHHADH	Q08426	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Intra	EHHADH	Q08426	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
Intra	EHHADH	Q08426	ZBTB8A	Homo sapiens	Q96BR9	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	ZBTB8A	Homo sapiens	Q96BR9	Validated Y2H	32296183
Intra	EHHADH	Q08426	ZBTB8A	Homo sapiens	Q96BR9	Y2H Array	32296183
Intra	EHHADH	Q08426	HID1	Homo sapiens	Q8IV36	Validated Y2H	32296183
Intra	EHHADH	Q08426	HID1	Homo sapiens	Q8IV36	Y2H Array	32296183
Intra	EHHADH	Q08426	HID1	Homo sapiens	Q8IV36	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	ZCCHC17	Homo sapiens	Q9NP64	Validated Y2H	32296183
Intra	EHHADH	Q08426	ZCCHC17	Homo sapiens	Q9NP64	Y2H Array	32296183
Intra	EHHADH	Q08426	ZCCHC17	Homo sapiens	Q9NP64	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	32296183
Intra	EHHADH	Q08426	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183
Intra	EHHADH	Q08426	CLK2	Homo sapiens	P49760	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	CLK2	Homo sapiens	P49760	Y2H Array	32296183
Intra	EHHADH	Q08426	LEPROTL1	Homo sapiens	O95214	Y2H Array	32296183
Intra	EHHADH	Q08426	LEPROTL1	Homo sapiens	O95214	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	ERGIC1	Homo sapiens	Q969X5	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	ERGIC1	Homo sapiens	Q969X5	Validated Y2H	32296183
Intra	EHHADH	Q08426	ERGIC1	Homo sapiens	Q969X5	Y2H Array	32296183
Intra	EHHADH	Q08426	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	EHHADH	Q08426	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	EHHADH	Q08426	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	EHHADH	Q08426	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	EHHADH	Q08426	NACC1	Homo sapiens	Q96RE7	Validated Y2H	32296183
Intra	EHHADH	Q08426	NACC1	Homo sapiens	Q96RE7	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	NACC1	Homo sapiens	Q96RE7	Y2H Array	32296183
Intra	EHHADH	Q08426	TRIM21	Homo sapiens	P19474	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	TRIM21	Homo sapiens	P19474	Y2H Array	32296183
Intra	EHHADH	Q08426	RUSF1	Homo sapiens	Q96GQ5	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	RUSF1	Homo sapiens	Q96GQ5	Validated Y2H	32296183
Intra	EHHADH	Q08426	RUSF1	Homo sapiens	Q96GQ5	Y2H Array	32296183
Intra	EHHADH	Q08426	CYB561	Homo sapiens	P49447	Y2H Prey Pooling	32296183
Intra	EHHADH	Q08426	CYB561	Homo sapiens	P49447	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Fanconi Renotubular Syndrome 3

FRTS3

Fanconi Renotubular Syndrome, Type 3

D-Bifunctional Protein Deficiency

Bifunctional Peroxisomal Enzyme Deficiency	17-Beta-Hydroxysteroid Dehydrogenase Iv Deficiency
Dbp Deficiency	Peroxisomal Bifunctional Enzyme Deficiency
Pbfe Deficiency	Bifunctional Enzyme Deficiency
Pseudo-Zellweger Syndrome	Zellweger-Like Syndrome
DBPD	Protein Deficiency, D-Bifunctional

Fanconi Syndrome

Infantile Nephropathic Cystinosis	Adult Fanconi Syndrome
Congenital Fanconi Syndrome	De Toni-Fanconi Syndrome
Fanconi-De Toni Syndrome	Lignac-Fanconi Syndrome
Fanconi Renotubular Syndrome	Primary Fanconi Renotubular Syndrome
De Toni-Debre-Fanconi Syndrome	Adult Fanconi Anemia
Detoni Fanconi Syndrome	Fanconi-De-Toni Syndrome
Primary Fanconi Syndrome	Detoni-Debre-Fanconi Syndrome
Primary Fanconi Renal Syndrome	Fanconi Anemia
Cystinosis, Infantile Nephropathic	Fanconi-Bickel Syndrome
Renal Fanconi Syndrome	Lowe-Bickel Syndrome

Adrenoleukodystrophy

X-Linked Adrenoleukodystrophy	ALD
Siemerling-Creutzfeldt Disease	X-Ald
X-Linked Cerebral Adrenoleukodystrophy	Bronze Schilder Disease
Melanodermic Leukodystrophy	Addison Disease And Cerebral Sclerosis
Adrenomyeloneuropathy, Adult	Diffuse Sclerosis
X-Cald	Adrenomyeloneuropathy
Encephalitis Periaxialis Concentrica	Encephalitis Periaxialis, Schilder'S
Sudanophilic Cerebral Sclerosis	Ald Childhood Cerebral Form
Adrenoleukodystrophy X-Linked Cerebral Form	Adrenoleukodystrophy Childhood Cerebral Form
Childhood Cerebral Ald	Schilder Disease
X-Linked Ald	Adrenoleukodystrophy, X-Linked
Amn	Diffuse Cerebral Sclerosis Of Schilder
Systemic Scleroderma	Balo'S Concentric Sclerosis
Ald - [Adrenoleukodystrophy]	Addison-Schilder

Zellweger Syndrome

Cerebrohepatorenal Syndrome	Zellweger Leukodystrophy
Zs	Congenital Iron Overload
Chr	Zws
Severe Pbd-Zsd	Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Mitochondrial Trifunctional Protein Deficiency

Tfp Deficiency	MTPD
Trifunctional Protein Deficiency	Trifunctional Protein Deficiency With Myopathy And Neuropathy
Tfpd	Familial Hypertrophic Cardiomyopathy
Cardiomyopathy Familial Hypertrophic	Familial Hcm
Heritable Hypertrophic Cardiomyopathy	Mtp Deficiency
Tpa Deficiency	Trifunctional Protein Deficiency, Type 2
Abetalipoproteinemia

3-Methylglutaconic Aciduria, Type I

3-Methylglutaconyl-Coa Hydratase Deficiency	3-Methylglutaconic Aciduria Type 1
Mga1	MGCA1
3mg-Coa Hydratase Deficiency	Mga Type I
Mga, Type I	3-Mg-Coa-Hydratase Deficiency
3 Methylglutaconyl Coa Hydratase Deficiency	3-Methylglutaconic Aciduria Type I
3 Alpha Methylglutaconic Aciduria Type I	3 Methylglutaconic Aciduria Type 1
3-Mgca Type I	3mg Coa Hydratase Deficiency
Auh Defect	Primary 3-Methylglutaconic Aciduria
3-Methylglutaconic Aciduria 1	3-Alpha-Methylglutaconic Aciduria Type 1
3-Alpha-Methylglutaconyl-Coa Hydratase Deficiency	3-@Methylglutaconic Aciduria, Type I
Megaloblastic Anemia Due To Inborn Errors Of Metabolism

Neonatal Adrenoleukodystrophy

Nald	Adrenoleukodystrophy Autosomal Neonatal Form
Intermediate Pbd-Zsd	Intermediate Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Adrenoleukodystrophy, Autosomal, Neonatal Form	Adrenoleukodystrophy Neonatal
Adrenoleukodystrophy, Neonatal

Ureter Transitional Cell Carcinoma

Transitional Cell Carcinoma Of Ureter

Ureteral Urothelial Cell Carcinoma

Aminoaciduria

Apical Myocardial Infarction

Peroxisomal Biogenesis Disorder

Zellweger Spectrum Disorders	Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum
Disorders Of Peroxisome Biogenesis	Zellweger Spectrum
Zellweger Syndrome Spectrum	Peroxisomal Biogenesis Disorders
Pbd, Zss	Pbd-Zsd
Pbd-Zss	Pbd-Zellweger Spectrum Disorder
Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum	Peroxisome Biogenesis Disorder
Peroxisome Biogenesis Disorder Spectrum	Peroxisome Biogenesis Disorders
Zellweger Spectrum Disorder	Hyperpipecolic Acidaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04226	EHHADH Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EHHADH	RGD	RGD:621441
Canis familiaris	EHHADH	VGNC	VGNC:40250
Bos taurus	EHHADH	VGNC	VGNC:53541
Felis catus	EHHADH	VGNC	VGNC:61766
Mus musculus	EHHADH	MGD	MGI:1277964
Macaca mulatta	EHHADH	VGNC	VGNC:72179

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