PPP1R16A - protein phosphatase 1 regulatory subunit 16A Gene

Homo sapiens

Also known as MYPT3

Gene ID: 84988 | Gene type: protein coding

About PPP1R16A

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,477,982-144,502,121 (from NCBI)

This gene has 11 transcripts (splice variants), 140 orthologues and 1 paralogue. Broad expression in duodenum (RPKM 18.4), small intestine (RPKM 14.8) and 25 other tissues.

Summary

Myosin light chain kinase and Phosphatase (MLCP) complexes control the phosphorylation states of regulatory Myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein Phosphatase 1 (PP1c) subunit, a myosin Phosphatase targeting (MYPT) subunit, and another smaller subunit. The protein encoded by this gene represents an MYPT subunit, which is responsible for directing PP1c to its intended targets. However, while the phosphorylation of Other MYPT members results in PP1c inactivation, phosphorylation of the encoded protein by protein kinase A results in PP1c activation. [provided by RefSeq, Jan 2020]

PPP1R16A Products(5)

mRNA	Protein	Name
NM_001329442.2	NP_001316371.1	protein phosphatase 1 regulatory subunit 16A
NM_001329443.2	NP_001316372.1	protein phosphatase 1 regulatory subunit 16A
NM_001329444.2	NP_001316373.1	protein phosphatase 1 regulatory subunit 16A
NM_001329445.2	NP_001316374.1	protein phosphatase 1 regulatory subunit 16A
NM_032902.7	NP_116291.1	protein phosphatase 1 regulatory subunit 16A

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1R16A Protein Structure

Ank_2

0
100
200
300
400
500
528 a.a.

Protein Preferred Names

Protein Names

protein phosphatase 1 regulatory subunit 16A

myosin phosphatase-targeting subunit 3

PPP1R16A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPP1R16A	Q96I34	TPP2	Homo sapiens	P29144	Y2H Array	31515488
Intra	PPP1R16A	Q96I34	TPP2	Homo sapiens	P29144	Y2H Prey Pooling	25416956
Intra	PPP1R16A	Q96I34	TPP2	Homo sapiens	P29144	Validated Y2H	25416956
Intra	PPP1R16A	Q96I34	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Prey Pooling	32296183
Intra	PPP1R16A	Q96I34	CKMT1A	Homo sapiens	P12532	Y2H Prey Pooling	32296183
Intra	PPP1R16A	Q96I34	CKMT1A	Homo sapiens	P12532	Y2H Array	32296183
Intra	PPP1R16A	Q96I34	PUF60	Homo sapiens	Q9UHX1	Pull Down	16169070
Intra	PPP1R16A	Q96I34	PUF60	Homo sapiens	Q9UHX1	Y2H Pooling	16169070
Intra	PPP1R16A	Q96I34	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	PPP1R16A	Q96I34	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	PPP1R16A	Q96I34	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	PPP1R16A	Q96I34	NEK6	Homo sapiens	Q9HC98-4	Validated Y2H	32296183
Intra	PPP1R16A	Q96I34	MCCD1	Homo sapiens	P59942	Y2H Prey Pooling	32296183
Intra	PPP1R16A	Q96I34	MCCD1	Homo sapiens	P59942	Y2H Array	32296183
Intra	PPP1R16A	Q96I34	NDUFAB1	Homo sapiens	O14561	Y2H Array	32296183
Intra	PPP1R16A	Q96I34	NDUFAB1	Homo sapiens	O14561	Y2H Prey Pooling	32296183
Intra	PPP1R16A	Q96I34	ATP23	Homo sapiens	Q9Y6H3	Y2H Prey Pooling	32296183
Intra	PPP1R16A	Q96I34	ATP23	Homo sapiens	Q9Y6H3	Validated Y2H	32296183
Intra	PPP1R16A	Q96I34	ATP23	Homo sapiens	Q9Y6H3	Y2H Array	32296183
Intra	PPP1R16A	Q96I34	UNKL	Homo sapiens	Q9H9P5-5	Validated Y2H	32296183
Intra	PPP1R16A	Q96I34	UNKL	Homo sapiens	Q9H9P5-5	Y2H Array	32296183
Intra	PPP1R16A	Q96I34	UNKL	Homo sapiens	Q9H9P5-5	Y2H Prey Pooling	32296183
Intra	PPP1R16A	Q96I34	C3orf36	Homo sapiens	Q3SXR2	Y2H Prey Pooling	32296183
Intra	PPP1R16A	Q96I34	C3orf36	Homo sapiens	Q3SXR2	Y2H Array	32296183
Intra	PPP1R16A	Q96I34	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	PPP1R16A	Q96I34	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	PPP1R16A	Q96I34	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	PPP1R16A	Q96I34	CHAT	Homo sapiens	P28329-3	Y2H Pooling	32814053
Intra	PPP1R16A	Q96I34	CHAT	Homo sapiens	P28329-3	Validated Y2H	32814053
Intra	PPP1R16A	Q96I34	CHAT	Homo sapiens	P28329-3	Y2H Array	32814053
Intra	PPP1R16A	Q96I34	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	PPP1R16A	Q96I34	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	PPP1R16A	Q96I34	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	PPP1R16A	Q96I34	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	PPP1R16A	Q96I34	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	PPP1R16A	Q96I34	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	PPP1R16A	Q96I34	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	PPP1R16A	Q96I34	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	PPP1R16A	Q96I34	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	PPP1R16A	Q96I34	PPP1CB	Homo sapiens	P62140	Y2H	21516116
Intra	PPP1R16A	Q96I34	PPP1CB	Homo sapiens	P62140	Y2H Array	32296183
Intra	PPP1R16A	Q96I34	PPP1CB	Homo sapiens	P62140	Y2H Prey Pooling	25416956
Intra	PPP1R16A	Q96I34	PPP1CB	Homo sapiens	P62140	Y2H Prey Pooling	32296183
Intra	PPP1R16A	Q96I34	PPP1CC	Homo sapiens	P36873	Y2H Array	32296183
Intra	PPP1R16A	Q96I34	PPP1CC	Homo sapiens	P36873	Y2H Prey Pooling	32296183
Intra	PPP1R16A	Q96I34	MRPL12	Homo sapiens	P52815	Y2H Prey Pooling	32296183
Intra	PPP1R16A	Q96I34	MRPL12	Homo sapiens	P52815	Y2H Array	32296183
Intra	PPP1R16A	Q96I34	TSSK3	Homo sapiens	Q96PN8	Y2H Array	32296183
Intra	PPP1R16A	Q96I34	TSSK3	Homo sapiens	Q96PN8	Validated Y2H	32296183
Intra	PPP1R16A	Q96I34	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	PPP1R16A	Q96I34	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	PPP1R16A	Q96I34	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	PPP1R16A	Q96I34	ANTKMT	Homo sapiens	Q9BQD7	Y2H Prey Pooling	32296183
Intra	PPP1R16A	Q96I34	ANTKMT	Homo sapiens	Q9BQD7	Validated Y2H	32296183
Intra	PPP1R16A	Q96I34	ANTKMT	Homo sapiens	Q9BQD7	Y2H Array	32296183
Intra	PPP1R16A	Q96I34	NDUFV2	Homo sapiens	P19404	Y2H Array	32814053
Intra	PPP1R16A	Q96I34	NDUFV2	Homo sapiens	P19404	Y2H Pooling	32814053
Intra	PPP1R16A	Q96I34	NDUFV2	Homo sapiens	P19404	Validated Y2H	32814053
Intra	PPP1R16A	Q96I34	TLE5	Homo sapiens	Q08117	Y2H Array	25416956
Intra	PPP1R16A	Q96I34	TLE5	Homo sapiens	Q08117	Y2H Prey Pooling	25416956
Intra	PPP1R16A	Q96I34	BATF2	Homo sapiens	Q8N1L9	Y2H Prey Pooling	32296183
Intra	PPP1R16A	Q96I34	BATF2	Homo sapiens	Q8N1L9	Y2H Array	32296183
Intra	PPP1R16A	Q96I34	ZNF414	Homo sapiens	Q96IQ9	Validated Y2H	32296183
Intra	PPP1R16A	Q96I34	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	PPP1R16A	Q96I34	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	PPP1R16A	Q96I34	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	PPP1R16A	Q96I34	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
Intra	PPP1R16A	Q96I34	AVPI1	Homo sapiens	Q5T686	Y2H Prey Pooling	32296183
Intra	PPP1R16A	Q96I34	AVPI1	Homo sapiens	Q5T686	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ovarian Clear Cell Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10988	PPP1R16A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PPP1R16A	VGNC	VGNC:33230
Canis familiaris	PPP1R16A	VGNC	VGNC:44884
Felis catus	PPP1R16A	VGNC	VGNC:64320
Rattus norvegicus	PPP1R16A	RGD	RGD:1307962
Mus musculus	PPP1R16A	MGD	MGI:1920312

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