TPSAB1 - tryptase alpha/beta 1 Gene

Homo sapiens

Also known as TPS1; TPS2; TPSB1; TPSB2; Tryptase-2

Gene ID: 7177 | Gene type: protein coding

About TPSAB1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,240,705-1,242,554 (from NCBI)

This gene has 5 transcripts (splice variants), 841 orthologues and 3 paralogues. Biased expression in gall bladder (RPKM 111.8), lung (RPKM 108.7) and 13 other tissues.

Summary

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]

TPSAB1 Products(1)

mRNA	Protein	Name
NM_003294.4	NP_003285.2	tryptase alpha/beta-1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	29661938	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17474147	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in extracellular matrix disassembly	IDA IDA: Inferred from direct assay	27068509	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TPSAB1 Protein Structure

Trypsin

0
100
200
275 a.a.

Protein Preferred Names

Protein Names

tryptase alpha/beta-1

Tryptase II

Recombinant TPSAB1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71125	TPSB2 Protein, Human (HEK293, His)	AAH29356.1 (A19-P275)	≥95%

Related Diseases

Diseases

Alias

Mastocytosis

Mast Cell Disease	Mast Cell Hyperplasia
Urticaria Pigmentosa	Malignant Mastocytoma
Malignant Mast Cell Tumours	Malignant Mastocytosis

Systemic Mastocytosis

Systemic Mast Cell Disease	Systemic Tissue Mast Cell Disease
Mastocytosis, Systemic	Smcd - Systemic Mast Cell Disease
Smcd	Mast Cell Disease, Systemic
Systemic Mast-Cell Disease	Systemic Mastocytoses
Mastocytosis Systemic	Corneal Dystrophy, Subepithelial Mucinous
Smcd - [Systemic Mast Cell Disease]

Hereditary Alpha Tryptasemia Syndrome

Mastocytosis, Cutaneous

Urticaria Pigmentosa	Cutaneous Mastocytosis
Diffuse Cutaneous Mastocytosis	Maculopapular Cutaneous Mastocytosis
Mastocytosis, Diffuse Cutaneous	MASTC
Mastocytosis, Maculopapular Cutaneous	Mastocytosis, Systemic, Somatic
Mastocytoma	Dcm
Diffuse Cutaneous Maculopapulous Mastocytosis	Up/Mpcm
Cm	Mastocytosis, Systemic
MASTSYS	Mast Cell Disease
Mast-Cell Disease	Mast Cell Leukemia
Mastocytosis, Indolent	Mastocytosis With Associated Hematologic Disorder
Mast Cell Neoplasm	Benign Mastocytoma

Chronic Pain

Vibratory Urticaria

Vibratory Angioedema	Dermodistortive Urticaria
VBU	Ddu
Angioedema, Vibratory

Candida Glabrata

Torulopsis Glabrata

Chlorhexidine Allergy

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Solitary Mastocytoma Of The Skin

Cutaneous Solitary Mastocytoma	Skin Mastocytoma
Solitary Mastocytoma	Solitary Mastocytoma Of Skin
Mastocytoma, Skin

Physical Urticaria

Symptomatic Dermographism

Polyposis Syndrome, Hereditary Mixed, 2

HMPS2	Hereditary Mixed Polyposis Syndrome 2
Polyposis Syndrome, Mixed Hereditary 2	Polyposis Syndrome, Hereditary Mixed, Type 2

Postural Orthostatic Tachycardia Syndrome

Irritable Heart	Mitral Valve Prolapse Syndrome
Neurocirculatory Asthenia	Orthostatic Intolerance Due To Net Deficiency
Familial Orthostatic Tachycardia Due To Norepinephrine Transporter Deficiency	Orhtostatic Intolerance
Postural Tachycardia Syndrome Due To Net Deficiency	Soldiers Heart

Gene Duplication Disease

Gene Duplication Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14952	TPSAB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TPSAB1	RGD	RGD:3066
Macaca fascicularis	TPSAB1	NCBI

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