TRPC5 - transient receptor potential cation channel subfamily C member 5 Gene

Homo sapiens

Also known as TRP5; PPP1R159

Gene ID: 7224 | Gene type: protein coding

About TRPC5

Cytogenetic location: Xq23 Genomic coordinates (GRCh38): X:111,768,011-112,082,776 (from NCBI)

This gene has 1 transcript (splice variant), 228 orthologues and 5 paralogues. Low expression observed in reference dataset.

Summary

This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including Calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010]

TRPC5 Products(1)

mRNA	Protein	Name
NM_012471.3	NP_036603.1	short transient receptor potential channel 5

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium channel activity	IDA IDA: Inferred from direct assay	20164195	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20164195	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of calcium channel complex	IDA IDA: Inferred from direct assay	20164195	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRPC5 Protein Structure

Ank_2

Ank

TRP_2

Ion_trans

0
200
400
600
800
973 a.a.

Protein Preferred Names

Protein Names

short transient receptor potential channel 5

TRP-5

Related Diseases

Diseases

Alias

Pyloric Stenosis

Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques

Olmsted Syndrome	Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques
Palmoplantar And Periorificial Keratoderma	Olms

Familial Episodic Pain Syndrome

Feps

Pseudohypoaldosteronism

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (8)

Cat. No.	Product Name	Purity	Rare Diseases
HY-17386	Rosiglitazone	99.94%	Yes
HY-14600	Rosiglitazone maleate	99.88%	Yes
HY-30234A	Clemizole hydrochloride	99.99%	Yes
HY-17386A	Rosiglitazone hydrochloride	99.31%	Yes
HY-17386B	Rosiglitazone potassium	/	Unkown
HY-14600R	Rosiglitazone maleate (Standard)	/	Unkown
HY-30234	Clemizole	/	Unkown
HY-B0700	Rosiglitazone sodium	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-162584	TRPC4/5-IN-2	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101507	Pico145	Inhibitor	99.40%	Unkown
HY-12949	ML204	Inhibitor	99.08%	Unkown
HY-112302	HC-070	Antagonist	99.73%	Unkown
HY-122051	AC1903	Inhibitor	99.80%	Unkown
HY-133168	Englerin A	Activator	99.50%	Unkown
HY-128205	BTD	Inhibitor	99.78%	Unkown
HY-12949A	ML204 hydrochloride	Inhibitor	99.70%	Unkown
HY-132813	Evifacotrep	Antagonist	99.55%	Unkown
HY-133012	GFB-8438	Inhibitor	98.41%	Unkown
HY-128561	AM12	Activator	/	Unkown
HY-142030	TRPC5 modulator-1	Modulator	/	Unkown
HY-144205	TRPC5-IN-2	Inhibitor	/	Unkown
HY-144208	TRPC5-IN-3	Inhibitor	/	Unkown
HY-144429	TRPC5-IN-4	Inhibitor	/	Unkown
HY-145150	TRPC5-IN-1	Inhibitor	/	Unkown
HY-146155	TRPC4/5-IN-1	Inhibitor	/	Unkown
HY-162090	TRPC antagonist 1	Antagonist	/	Unkown
HY-17386S	Rosiglitazone-d3		/	Unkown
HY-RS15108	TRPC5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-17386S1	Rosiglitazone-d4		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TRPC5	VGNC	VGNC:66585
Rattus norvegicus	TRPC5	RGD	RGD:619787
Bos taurus	TRPC5	VGNC	VGNC:36385
Canis familiaris	TRPC5	VGNC	VGNC:47870
Mus musculus	TRPC5	MGD	MGI:109524
Macaca mulatta	TRPC5	VGNC	VGNC:78653

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