DNAJC7 - DnaJ heat shock protein family (Hsp40) member C7 Gene

Homo sapiens

Also known as DJ11; DJC7; TPR2; TTC2

Gene ID: 7266 | Gene type: protein coding

About DNAJC7

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:41,976,435-42,017,439 (from NCBI)

This gene has 42 transcripts (splice variants), 278 orthologues and 20 paralogues. Ubiquitous expression in brain (RPKM 25.3), lymph node (RPKM 14.6) and 25 other tissues.

Summary

This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chaperone proteins heat shock proteins 70 and 90 in an ATP-dependent manner and may function as a co-chaperone. Pseudogenes of this gene are found on chromosomes 1 and 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

DNAJC7 Products(2)

mRNA	Protein	Name
NM_001144766.3	NP_001138238.1	dnaJ homolog subfamily C member 7 isoform 2
NM_003315.4	NP_003306.3	dnaJ homolog subfamily C member 7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	12853476	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17043677	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chaperone cofactor-dependent protein refolding	IDA IDA: Inferred from direct assay	12853476	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12853476	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJC7 Protein Structure

TPR_11

TPR_9

TPR_1

TPR_11

TPR_1

DnaJ

0
100
200
300
400
494 a.a.

Protein Preferred Names

Protein Names

dnaJ homolog subfamily C member 7

DnaJ (Hsp40) homolog, subfamily C, member 7

Related Diseases

Diseases

Alias

Fatal Infantile Hypertonic Myofibrillar Myopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03888	DNAJC7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DNAJC7	VGNC	VGNC:98904
Canis familiaris	DNAJC7	VGNC	VGNC:55643
Bos taurus	DNAJC7	VGNC	VGNC:55817
Macaca mulatta	DNAJC7	VGNC	VGNC:99144
Rattus norvegicus	DNAJC7	RGD	RGD:1303226
Mus musculus	DNAJC7	MGD	MGI:1928373

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