CDK11A - cyclin dependent kinase 11A Gene

Homo sapiens

Also known as CDC2L2; CDC2L3; p58GTA; PITSLRE; CDK11-p46; CDK11-p58; CDK11-p110

Gene ID: 728642 | Gene type: protein coding

About CDK11A

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,702,379-1,724,357 (from NCBI)

This gene has 23 transcripts (splice variants), 202 orthologues and 26 paralogues. Ubiquitous expression in bone marrow (RPKM 22.4), small intestine (RPKM 18.4) and 25 other tissues.

Summary

This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell Apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

CDK11A Products(4)

mRNA	Protein	Name
NM_001313896.2	NP_001300825.1	cyclin-dependent kinase 11A isoform 5
NM_001313982.2	NP_001300911.1	cyclin-dependent kinase 11A isoform 3
NM_024011.4	NP_076916.2	cyclin-dependent kinase 11A isoform 1
NM_033529.4	NP_277071.2	cyclin-dependent kinase 11A isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	12501247	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22939624	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12501247	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	12501247	GOA
involved in regulation of RNA splicing	IDA IDA: Inferred from direct assay	12501247	GOA
involved in regulation of cell growth	IEP IEP: Inferred from expression pattern	10882096	GOA
involved in regulation of mRNA processing	IDA IDA: Inferred from direct assay	12501247	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of cyclin-dependent protein kinase holoenzyme complex	IPI IPI: Inferred from physical interaction	18216018	GOA
located in nucleus	IDA IDA: Inferred from direct assay	8195233	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK11A Protein Structure

Pkinase

0
200
400
600
783 a.a.

Protein Preferred Names

Protein Names

cyclin-dependent kinase 11A

PITSLRE B

CDK11A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CDK11A	Q9UQ88	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Childhood Endodermal Sinus Tumor

Childhood Endodermal Sinus Neoplasm	Childhood Endodermal Sinus Tumour
Paediatric Yolk Sac Tumour	Pediatric Yolk Sac Tumor
Childhood Yolk Sac Tumor

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

Star Syndrome	Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome
Syndactyly With Renal And Anogenital Malformations	STAR
Syndactyly, Telecanthus, Anogenital And Renal Malformations	Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-155874	ZNL-05-044	Inhibitor	99.91%	Unkown
HY-RS02352	CDK11A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CDK11A	MGD	MGI:88353

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