2. Gene
  3. UBE2E1 - ubiquitin conjugating enzyme E2 E1 Gene

UBE2E1 - ubiquitin conjugating enzyme E2 E1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as UBCH6

Gene ID: 7324 | Gene type: protein coding

About UBE2E1

Cytogenetic location: 3p24.2 Genomic coordinates (GRCh38): 3:23,805,955-23,891,640 (from NCBI)

This gene has 11 transcripts (splice variants), 148 orthologues and 12 paralogues. Ubiquitous expression in lymph node (RPKM 26.5), brain (RPKM 25.3) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

UBE2E1 Products(3)

mRNA Protein Name
NM_001202476.2 NP_001189405.1 ubiquitin-conjugating enzyme E2 E1 isoform 3
NM_003341.5 NP_003332.1 ubiquitin-conjugating enzyme E2 E1 isoform 1
NM_182666.3 NP_872607.1 ubiquitin-conjugating enzyme E2 E1 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ISG15 transferase activity IDA
IDA: Inferred from direct assay
16428300 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16307923 GOA
enables ubiquitin conjugating enzyme activity IDA
IDA: Inferred from direct assay
15247280 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
16307923 GOA
Biological Process GO Annotation Evidence Reference Source
involved in ISG15-protein conjugation IDA
IDA: Inferred from direct assay
16428300 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16307923 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
15247280 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
9990509 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
18845142 GOA
part of ubiquitin ligase complex IDA
IDA: Inferred from direct assay
16307923 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2E1 Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (51 - 187)

  • 0
  • 100
  • 193 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 E1

(E3-independent) E2 ubiquitin-conjugating enzyme E1

UBE2E1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
UBE2E1 P51965 OTUB1 Homo sapiens Q96FW1
Y2H
19549727
Intra
UBE2E1 P51965 ZNRF1 Homo sapiens Q8ND25
Enzymatic Study
19549727
Intra
UBE2E1 P51965 ZNRF1 Homo sapiens Q8ND25
Y2H Array
19690564
Intra
UBE2E1 P51965 PAF1 Homo sapiens Q8N7H5
Pull Down
16307923
Intra
UBE2E1 P51965 RNF11 Homo sapiens Q9Y3C5
Enzymatic Study
19549727
Intra
UBE2E1 P51965 RNF11 Homo sapiens Q9Y3C5
Y2H Array
19549727
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Limb-Girdle Muscular Dystrophy

Lgmd

Limb Girdle Muscular Dystrophy

Muscular Dystrophies, Limb-Girdle

Erb'S Muscular Dystrophy

Leyden-Mbius Muscular Dystrophy

Limb-Girdle Syndrome

Myopathic Limb-Girdle Syndrome

Limb Girdle

Muscular Dystrophy Limb-Girdle

Dystrophy, Muscular, Limb-Girdle

Lgmd - [Limb-Girdle Muscular Dystrophy]

Limb Girdle Muscle Dystrophy

Limb-Girdle Myopathy
Immunodeficiency 33

IMD33

X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Ikbkg Deficiency

X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Nemo Deficiency

X-Linked Msmd Due To Ikbkg Deficiency

X-Linked Msmd Due To Nemo Deficiency

Invasive Pneumococcal Disease, Recurrent Isolated, 2

Invasive Pneumococcal Disease, Recurrent Isolated, 2, Formerly

Ipd2, Formerly

Nf-Kappa B Essential Modulator Deficiency

Familial X-Linked 1 Atypical Mycobacteriosis

Nemo Deficiency Syndrome

Amcbx1

Familial, X-Linked, Atypical Mycobacteriosis 1

Ipd2

Recurrent Isolated Invasive Pneumococcal Disease 2

X-Linked Disseminated Atypical Mycobacterial Infection Type 1

X-Linked Immunodeficiency 33, Mycobacteriosis

X-Linked Susceptibility To Mycobacterial Disease Type 1

Invasive Pneumococcal Disease, Recurrent Isolated, Type 2

Atypical Mycobacteriosis, Familial, X-Linked 1
Spinocerebellar Ataxia 1

Spinocerebellar Ataxia Type 1

SCA1

Olivopontocerebellar Atrophy I

Opca1

Opca4

Menzel Type Opca

Schut-Haymaker Type Opca

Spinocerebellar Atrophy I

Opca I

Olivopontocerebellar Atrophy Iv

Opca Iv

Cerebelloparenchymal Disorder I

Cpd1

Olivopontocerebellar Atrophy 1

Cerebelloparenchymal Disorder 1

Olivopontocerebellar Atrophy 4

Spinocerebellar Atrophy 1

Type 1 Spinocerebellar Ataxia

Spinocerebellar Ataxia-1

Ataxia, Spinocerebellar, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15342 UBE2E1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris UBE2E1 VGNC VGNC:52908
Rattus norvegicus UBE2E1 RGD RGD:2324438
Bos taurus UBE2E1 VGNC VGNC:107009
Mus musculus UBE2E1 MGD MGI:107411
Macaca mulatta UBE2E1 VGNC VGNC:78694
Felis catus UBE2E1 VGNC VGNC:102860
Others UBE2E1 NCBI