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  2. UCHL3 - ubiquitin C-terminal hydrolase L3 Gene

UCHL3 - ubiquitin C-terminal hydrolase L3 Gene

Homo sapiens

Also known as UCH-L3

Gene ID: 7347 | Gene type: protein coding

About UCHL3

Cytogenetic location: 13q22.2 Genomic coordinates (GRCh38): 13:75,549,502-75,606,020 (from NCBI)

This gene has 6 transcripts (splice variants), 216 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 5.1), testis (RPKM 4.9) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the deubiquitinating Enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

UCHL3 Products(2)

mRNA Protein Name
NM_001270952.2 NP_001257881.1 ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 1
NM_006002.5 NP_005993.1 ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables cysteine-type deubiquitinase activity EXP
EXP: Inferred from Experiment
26235645 GOA
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
9521656 GOA
enables peptidase activity IDA
IDA: Inferred from direct assay
21762696 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19615732 GOA
enables ubiquitin binding IDA
IDA: Inferred from direct assay
19154770 GOA
Biological Process GO Annotation Evidence Reference Source
involved in protein catabolic process IDA
IDA: Inferred from direct assay
21762696 GOA
involved in protein deubiquitination IDA
IDA: Inferred from direct assay
9521656 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UCHL3 Protein Structure

Peptidase_C12

Peptidase_C12: Ubiquitin carboxyl-terminal hydrolase, family 1 (5 - 215)

  • 0
  • 100
  • 200
  • 230 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase isozyme L3

testicular tissue protein Li 221

UCHL3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
UCHL3 P15374 CLPB Homo sapiens Q9H078 33961781
Intra
UCHL3 P15374 CLPB Homo sapiens Q9H078 19615732
Intra
UCHL3 P15374 SPRED1 Homo sapiens Q7Z699 32814053
Intra
UCHL3 P15374 SPRED1 Homo sapiens Q7Z699 32814053
Intra
UCHL3 P15374 SPRED1 Homo sapiens Q7Z699 32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UCHL3 Proteins

Cat. No. Product Name Accession Purity
HY-P71115 UCHL3 Protein, Human (His) P15374 (M1-A230) ≥95%

UCHL3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83066 UCHL3 Antibody (YA2811) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta UCHL3 VGNC VGNC:78706
Bos taurus UCHL3 VGNC VGNC:36632
Rattus norvegicus UCHL3 RGD RGD:1561196
Mus musculus UCHL3 MGD MGI:1355274
Felis catus UCHL3 VGNC VGNC:66796
Canis familiaris UCHL3 VGNC VGNC:48104
Others UCHL3 NCBI