2. Gene
  3. Vsir - V-set immunoregulatory receptor Gene

Vsir - V-set immunoregulatory receptor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Dies1; PD-1H; VISTA; 4632428N05Rik

Gene ID: 74048 | Gene type: protein coding

About Vsir

Summary

Predicted to enable endopeptidase activator activity; Enzyme binding activity; and identical protein binding activity. Acts upstream of or within several processes, including negative regulation of CD4-positive, alpha-beta T cell proliferation; negative regulation of T cell cytokine production; and positive regulation of BMP signaling pathway. Located in external side of plasma membrane. Is expressed in several structures, including heart; immune system; lung; male reproductive gland or organ; and small intestine lamina propria. Orthologous to human VSIR (V-set immunoregulatory receptor). [provided by Alliance of Genome Resources, Apr 2022]

Vsir Products(2)

mRNA Protein Name
NM_001159572.1 NP_001153044.1 V-type immunoglobulin domain-containing suppressor of T-cell activation isoform 2 precursor
NM_028732.4 NP_083008.1 V-type immunoglobulin domain-containing suppressor of T-cell activation isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20042595 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of BMP signaling pathway IGI
IGI: Inferred from genetic interaction
20042595 MGI
acts upstream of or within BMP signaling pathway IGI
IGI: Inferred from genetic interaction
22751012 MGI
acts upstream of BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
20042595 MGI
acts upstream of or within negative regulation of CD4-positive, alpha-beta T cell proliferation IDA
IDA: Inferred from direct assay
21383057 MGI
acts upstream of or within negative regulation of T cell cytokine production IDA
IDA: Inferred from direct assay
21383057 MGI
acts upstream of or within positive regulation of BMP signaling pathway IGI
IGI: Inferred from genetic interaction
20042595 MGI
acts upstream of or within positive regulation of BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
20042595 MGI
acts upstream of or within positive regulation of stem cell differentiation IGI
IGI: Inferred from genetic interaction
22751012 MGI
acts upstream of stem cell differentiation IGI
IGI: Inferred from genetic interaction
22751012 MGI
acts upstream of or within stem cell differentiation IMP
IMP: Inferred from mutant phenotype
20042595 MGI
Cellular Component GO Annotation Evidence Reference Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
20042595 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
20042595 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

V-type immunoglobulin domain-containing suppressor of T-cell activation

V-set domain-containing immunoregulatory receptor

differentiation of ESCs 1

platelet receptor Gi24

Recombinant Vsir Proteins

Cat. No. Product Name Accession Purity
HY-P72428 VISTA/B7-H5 Protein, Mouse (159a.a, HEK293, His) Q9D659 (F33-A191) ≥95%
HY-P73547 VISTA/B7-H5 Protein, Mouse (HEK293, Fc) Q9D659 (F33-A194) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15711 VSIR Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vsir NCBI NCBI:64115