Grip1 - glutamate receptor interacting protein 1 Gene

Mus musculus

Also known as eb; GRIP; 4931400F03Rik

Gene ID: 74053 | Gene type: protein coding

About Grip1

Summary

This gene encodes a protein containing multiple PDZ (post synaptic density protein, Drosophila disc large tumor suppressor, and zonula occludens-1 protein) domains. The encoded protein acts as a mediator between cytoskeletal and membrane proteins, particularly in neuronal cells, and facilitates complex formation at the cell membrane. Mutation of this gene can cause embryonic lethality resulting from defects of the dermo-epidermal junction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Grip1 Products(10)

mRNA	Protein	Name
NM_001277292.1	NP_001264221.1	glutamate receptor-interacting protein 1 isoform 4
NM_001277293.1	NP_001264222.1	glutamate receptor-interacting protein 1 isoform 5
NM_001277294.1	NP_001264223.1	glutamate receptor-interacting protein 1 isoform 6
NM_001277295.1	NP_001264224.1	glutamate receptor-interacting protein 1 isoform 7
NM_001358809.1	NP_001345738.1	glutamate receptor-interacting protein 1 isoform 8
NM_001358810.1	NP_001345739.1	glutamate receptor-interacting protein 1 isoform 9
NM_001358811.1	NP_001345740.1	glutamate receptor-interacting protein 1 isoform 10
NM_028736.2	NP_083012.1	glutamate receptor-interacting protein 1 isoform 1
NM_130891.2	NP_570961.1	glutamate receptor-interacting protein 1 isoform 2
NM_133442.2	NP_597699.1	glutamate receptor-interacting protein 1 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9883737	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in neurotransmitter receptor transport, endosome to postsynaptic membrane	IDA IDA: Inferred from direct assay	20956289	MGI
involved in neurotransmitter receptor transport, endosome to postsynaptic membrane	IEP IEP: Inferred from expression pattern	20956289	MGI
involved in neurotransmitter receptor transport, endosome to postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	20956289	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	14730302	MGI
involved in vesicle-mediated transport in synapse	IDA IDA: Inferred from direct assay	20956289	MGI
involved in vesicle-mediated transport in synapse	IEP IEP: Inferred from expression pattern	20956289	MGI
involved in vesicle-mediated transport in synapse	IMP IMP: Inferred from mutant phenotype	20956289	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20956289	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	20956289	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	20956289	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	10197531	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	15207857	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15207857	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glutamate receptor-interacting protein 1

eye blebs

Grip1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Grip1	Q925T6	Vdr	Mus musculus	P48281	Y2H	12529369
Intra	Grip1	Q925T6	Ephb2	Mus musculus	P54763	Pull Down	9883737
Intra	Grip1	Q925T6	Gria2	Mus musculus	P23819	Anti Bait CoIP	12458226
Intra	Grip1	Q925T6	Cspg4	Mus musculus	Q8VHY0	Anti Bait CoIP	12458226
Intra	Grip1	Q925T6	Cspg4	Mus musculus	Q8VHY0	Anti Tag CoIP	12458226

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05809	GRIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grip1	NCBI	NCBI:23426

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