Cspg4 - chondroitin sulfate proteoglycan 4 Gene

Mus musculus

Also known as AN2; NG2; Cspg4a; 4732461B14Rik

Gene ID: 121021 | Gene type: protein coding

About Cspg4

Summary

Enables coreceptor activity. Acts upstream of or within several processes, including platelet-derived growth factor receptor signaling pathway; positive regulation of MAPK cascade; and ruffle assembly. Located in plasma membrane and ruffle. Is expressed in several structures, including brain; jaw; respiratory system; retina; and skeleton. Human ortholog(s) of this gene implicated in relapsing-remitting multiple sclerosis. Orthologous to human CSPG4 (chondroitin sulfate proteoglycan 4). [provided by Alliance of Genome Resources, Apr 2022]

Cspg4 Products(1)

mRNA	Protein	Name
NM_139001.2	NP_620570.2	chondroitin sulfate proteoglycan 4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables coreceptor activity	IDA IDA: Inferred from direct assay	26437238	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12458226	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within glial cell migration	IDA IDA: Inferred from direct assay	10366628	MGI
acts upstream of or within platelet-derived growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	26437238	MGI
acts upstream of or within positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	10036240	MGI
acts upstream of or within ruffle assembly	IDA IDA: Inferred from direct assay	26437238	MGI
acts upstream of or within substrate-dependent cell migration	IGI IGI: Inferred from genetic interaction	26437238	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell projection	IDA IDA: Inferred from direct assay	23447615	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	11668599	MGI
located in ruffle	IDA IDA: Inferred from direct assay	26437238	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

chondroitin sulfate proteoglycan 4

AN2 proteoglycan	AN2/NG2 proteoglycan
chondroitin sulfate proteoglycan NG2	nerve/glial antigen 2
proteoglycan AN2

Cspg4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Cspg4	Q8VHY0	Grip1	Mus musculus	Q925T6	Anti Bait CoIP	12458226
Intra	Cspg4	Q8VHY0	Grip1	Mus musculus	Q925T6	Y2H Pooling	12458226
Intra	Cspg4	Q8VHY0	Grip1	Mus musculus	Q925T6	Anti Tag CoIP	12458226
Intra	Cspg4	Q8VHY0	Gria2	Mus musculus	P23819	Anti Bait CoIP	12458226

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03254	CSPG4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cspg4	NCBI	NCBI:1464
Macaca fascicularis	Cspg4	NCBI

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