VSNL1 - visinin like 1 Gene

Homo sapiens

Also known as HLP3; VILIP; HPCAL3; HUVISL1; VILIP-1

Gene ID: 7447 | Gene type: protein coding

About VSNL1

Cytogenetic location: 2p24.2 Genomic coordinates (GRCh38): 2:17,539,972-17,657,018 (from NCBI)

This gene has 6 transcripts (splice variants), 263 orthologues and 14 paralogues. Biased expression in brain (RPKM 206.9), esophagus (RPKM 16.5) and 2 other tissues.

Summary

This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

VSNL1 Products(5)

mRNA	Protein	Name
NM_001366803.2	NP_001353732.1	visinin-like protein 1 isoform 1
NM_001366804.2	NP_001353733.1	visinin-like protein 1 isoform 2
NM_001366805.2	NP_001353734.1	visinin-like protein 1 isoform 3
NM_001366806.2	NP_001353735.1	visinin-like protein 1 isoform 1
NM_003385.5	NP_003376.2	visinin-like protein 1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VSNL1 Protein Structure

EF-hand_1

EF-hand_7

0
100
191 a.a.

Protein Preferred Names

Protein Names

visinin-like protein 1

VLP-1

Recombinant VSNL1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71427	VSNL1 Protein, Human (His)	P62760 (M1-K191)	≥95%
HY-P76694	VSNL1 Protein, Human	P62760 (G2-K191)	≥95%

Related Diseases

Diseases

Alias

Abcd Syndrome

ABCDS	Albinism, Black Lock, Cell Migration Disorder Of The Neurocytes Of The Gut, And Deafness
Albinism, Black Lock, Cell Migration Disorder Of The Neurocytes Of The Gut And Deafness

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Dementia, Lewy Body

Lewy Body Dementia	Lewy Body Disease
Diffuse Lewy Body Disease	Dementia With Lewy Bodies
DLB	Autosomal Dominant Diffuse Lewy Body Disease
Cortical Lewy Body Disease	Dementia, Lewy Body, Susceptibility To
Lewy Body Dementia, Susceptibility To	Senile Dementia Of The Lewy Body Type
Dementia Of The Lewy Body Type	Lbd
Diffuse Lewy Body Disease With Gaze Palsy	Dysphasic Dementia Hereditary
Lewy Body Type Senile Dementia	Lewy Body Variant Of Alzheimer Disease
Lewy Bodies	Lewy Body
Dlbd - [Diffuse Lewy Body Disease]	Clbd - [Cortical Lewy Body Disease]

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15712	VSNL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	VSNL1	VGNC	VGNC:36841
Felis catus	VSNL1	VGNC	VGNC:66981
Macaca mulatta	VSNL1	VGNC	VGNC:106244
Mus musculus	VSNL1	MGD	MGI:1349453
Rattus norvegicus	VSNL1	RGD	RGD:3966
Others	VSNL1	NCBI

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