C1QTNF2 - C1q and TNF related 2 Gene

Homo sapiens

Also known as CTRP2; zacrp2

Gene ID: 114898 | Gene type: protein coding

About C1QTNF2

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:160,347,754-160,370,626 (from NCBI)

This gene has 2 transcripts (splice variants), 188 orthologues and 23 paralogues. Broad expression in testis (RPKM 1.3), lung (RPKM 1.2) and 23 other tissues.

Summary

Predicted to enable identical protein binding activity and signaling receptor binding activity. Predicted to be involved in regulation of lipid metabolic process. Predicted to act upstream of or within positive regulation of MAPK cascade; positive regulation of glucose import; and positive regulation of small molecule metabolic process. Predicted to be located in extracellular space. Predicted to be part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

C1QTNF2 Products(2)

mRNA	Protein	Name
NM_001366504.1	NP_001353433.1	complement C1q tumor necrosis factor-related protein 2 isoform 2 precursor
NM_031908.6	NP_114114.3	complement C1q tumor necrosis factor-related protein 2 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C1QTNF2 Protein Structure

Collagen

C1q

0
100
200
300
330 a.a.

Protein Preferred Names

Protein Names

complement C1q tumor necrosis factor-related protein 2

C1q and tumor necrosis factor related protein 2

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 19

RP19	Retinitis Pigmentosa-19
Retinitis Pigmentosa, Type 19

Late-Onset Retinal Degeneration

LORD	Retinal Degeneration, Late-Onset, Autosomal Dominant
Autosomal Dominant Late-Onset Retinal Degeneration	Pigmentary Retinopathy
Retinal Degeneration, Late-Onset	Retinitis Pigmentosa

Vertigo, Benign Recurrent

Benign Paroxysmal Positional Vertigo	Bppv
Vestibulopathy, Familial	BRV
Vertigo, Benign Paroxysmal Positional	Benign Paroxysmal Positional Nystagmus
Benign Recurrent Vertigo	Familial Benign Recurrent Vertigo
Familial Vestibulopathy	Benign Paroxysmal Nystagmus
Bppv - [Benign Positional Paroxysmal Vertigo]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01728	C1QTNF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	C1QTNF2	VGNC	VGNC:38583
Felis catus	C1QTNF2	VGNC	VGNC:102169
Rattus norvegicus	C1QTNF2	RGD	RGD:1561041
Macaca mulatta	C1QTNF2	VGNC	VGNC:70312
Mus musculus	C1QTNF2	MGD	MGI:1916433
Bos taurus	C1QTNF2	VGNC	VGNC:26624

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