2. Gene
  3. SPRY3 - sprouty RTK signaling antagonist 3 Gene

SPRY3 - sprouty RTK signaling antagonist 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as spry-3

Gene ID: 10251 | Gene type: protein coding

About SPRY3

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:155,612,586-155,782,459 (from NCBI)

This gene has 4 transcripts (splice variants), 175 orthologues and 3 paralogues. Low expression observed in reference dataset.

Summary

Involved in negative regulation of MAPK cascade. Predicted to be located in membrane. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

SPRY3 Products(5)

mRNA Protein Name
NM_001304990.2 NP_001291919.1 protein sprouty homolog 3
NM_001394353.1 NP_001381282.1 protein sprouty homolog 3
NM_001394354.1 NP_001381283.1 protein sprouty homolog 3
NM_001394355.1 NP_001381284.1 protein sprouty homolog 3
NM_005840.4 NP_005831.1 protein sprouty homolog 3
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17974561 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
30878395 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPRY3 Protein Structure

Sprouty

Sprouty: Sprouty protein (Spry) (152 - 263)

  • 0
  • 100
  • 200
  • 288 a.a.
Protein Preferred Names Protein Names

protein sprouty homolog 3

antagonist of FGF signaling

SPRY3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SPRY3 O43610 CREB5 Homo sapiens Q02930-3
Validated Y2H
32296183
Intra
SPRY3 O43610 LCE3E Homo sapiens Q5T5B0
Validated Y2H
32296183
Intra
SPRY3 O43610 LCE1B Homo sapiens Q5T7P3
Validated Y2H
32296183
Intra
SPRY3 O43610 KRT34 Homo sapiens O76011
Validated Y2H
32296183
Intra
SPRY3 O43610 SLC39A7 Homo sapiens Q92504
Validated Y2H
32296183
Intra
SPRY3 O43610 KPRP Homo sapiens Q5T749
Validated Y2H
32296183
Intra
SPRY3 O43610 NEK6 Homo sapiens Q9HC98-4
Validated Y2H
32296183
Intra
SPRY3 O43610 LCE1F Homo sapiens Q5T754
Validated Y2H
32296183
Intra
SPRY3 O43610 LCE1A Homo sapiens Q5T7P2
Validated Y2H
32296183
Intra
SPRY3 O43610 GNE Homo sapiens Q9Y223-2
Validated Y2H
32296183
Intra
SPRY3 O43610 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
SPRY3 O43610 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
SPRY3 O43610 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
SPRY3 O43610 GPSM3 Homo sapiens Q9Y4H4
Validated Y2H
32296183
Intra
SPRY3 O43610 ZDHHC17 Homo sapiens Q8IUH5
Validated Y2H
32296183
Intra
SPRY3 O43610 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra
SPRY3 O43610 ZNF655 Homo sapiens Q8N720
Validated Y2H
32296183
Intra
SPRY3 O43610 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra
SPRY3 O43610 ZNF587 Homo sapiens Q96SQ5
Validated Y2H
32296183
Intra
SPRY3 O43610 LCE3D Homo sapiens Q9BYE3
Validated Y2H
32296183
Intra
SPRY3 O43610 HOXA1 Homo sapiens P49639
Validated Y2H
32296183
Intra
SPRY3 O43610 VSNL1 Homo sapiens P62760
Validated Y2H
32296183
Intra
SPRY3 O43610 CATSPER1 Homo sapiens Q8NEC5
Validated Y2H
32296183
Intra
SPRY3 O43610 BEX2 Homo sapiens Q9BXY8
Validated Y2H
32296183
Intra
SPRY3 O43610 AQP1 Homo sapiens P29972
Validated Y2H
32296183
Intra
SPRY3 O43610 LCE3A Homo sapiens Q5TA76
Validated Y2H
32296183
Intra
SPRY3 O43610 MAPKBP1 Homo sapiens O60336
Validated Y2H
32296183
Intra
SPRY3 O43610 CHRD Homo sapiens Q9H2X0
Validated Y2H
32296183
Intra
SPRY3 O43610 R3HDM2 Homo sapiens Q9Y2K5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Legius Syndrome

Neurofibromatosis Type 1-Like Syndrome

Nfls

LGSS

Neurofibromatosis 1-Like Syndrome

Neurofibromatosis Type 1 Like Syndrome

Nf1-Like Syndrome

Neurofibromatosis, Type 1-Like Syndrome
Intellectual Developmental Disorder, X-Linked 108

MRX108

X-Linked Intellectual Developmental Disorder 108

Mental Retardation, X-Linked 108

Mental Retardation, X-Linked, Type 108
Colorblindness, Partial, Protan Series

Protanopia

Red Color Blindness

Protan Defect

CBP

Red Colorblindness

Colorblindness, Protan

Color Blindness, Red
Red-Green Color Blindness

Deutan Defect

Deuteranopia

Reduced Red-Green Discrimination

Color Blindness, Red-Green

Colorblindness, Partial, Deutan Series
Multiminicore Disease

Multiminicore Myopathy

Mmd

Minicore Disease

Minicore Myopathy

Multi-Core Congenital Myopathy

Multi-Core Disease

Multi-Minicore Disease

Multicore Disease

Multicore Myopathy

Minicore Myopathy With External Ophthalmoplegia
Malignant Hyperthermia

Anesthesia Related Hyperthermia

Malignant Hyperpyrexia Due To Anesthesia

Hyperpyrexia, Malignant

Hyperthermia, Malignant

Malignant Hyperpyrexia

Mhs

Malignant Fever
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13723 SPRY3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SPRY3 VGNC VGNC:65651
Mus musculus SPRY3 MGD MGI:1345188
Bos taurus SPRY3 VGNC VGNC:35243
Rattus norvegicus SPRY3 RGD RGD:1562172