2. Gene
  3. CORO2A - coronin 2A Gene

CORO2A - coronin 2A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IR10; WDR2; CLIPINB

Gene ID: 7464 | Gene type: protein coding

About CORO2A

Cytogenetic location: 9q22.33 Genomic coordinates (GRCh38): 9:98,120,975-98,192,637 (from NCBI)

This gene has 2 transcripts (splice variants), 283 orthologues and 6 paralogues. Broad expression in small intestine (RPKM 15.5), duodenum (RPKM 14.7) and 16 other tissues.

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

CORO2A Products(2)

mRNA Protein Name
NM_003389.3 NP_003380.3 coronin-2A
NM_052820.4 NP_438171.1 coronin-2A
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21331046 GOA
Cellular Component GO Annotation Evidence Reference Source
part of transcription repressor complex IDA
IDA: Inferred from direct assay
12628926 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CORO2A Protein Structure

DUF1899

DUF1899: Domain of unknown function (DUF1899) (6 - 69)

WD40

WD40: WD domain, G-beta repeat (79 - 111)

WD40

WD40: WD domain, G-beta repeat (127 - 161)

WD40

WD40: WD domain, G-beta repeat (172 - 208)

Trimer_CC

Trimer_CC: Trimerisation motif (261 - 397)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 525 a.a.
Protein Preferred Names Protein Names

coronin-2A

WD protein IR10

Related Diseases

Diseases Alias
Louping Ill
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03051 CORO2A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CORO2A VGNC VGNC:71451
Rattus norvegicus CORO2A RGD RGD:1309719
Bos taurus CORO2A VGNC VGNC:27623
Mus musculus CORO2A MGD MGI:1345966
Canis familiaris CORO2A VGNC VGNC:39529
Felis catus CORO2A VGNC VGNC:61104