DAGLA - diacylglycerol lipase alpha Gene

Homo sapiens

Also known as NSDDR; C11orf11; DAGLALPHA; DAGL(ALPHA)

Gene ID: 747 | Gene type: protein coding

About DAGLA

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:61,680,391-61,747,001 (from NCBI)

This gene has 2 transcripts (splice variants), 195 orthologues and 3 paralogues. Broad expression in brain (RPKM 6.7), colon (RPKM 2.0) and 20 other tissues.

Summary

This gene encodes a diacylglycerol Lipase. The encoded Enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.[provided by RefSeq, Nov 2010]

DAGLA Products(1)

mRNA	Protein	Name
NM_006133.3	NP_006124.1	diacylglycerol lipase-alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23502535	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in arachidonate metabolic process	IDA IDA: Inferred from direct assay	14610053	GOA
involved in diacylglycerol catabolic process	IDA IDA: Inferred from direct assay	14610053	GOA
involved in diacylglycerol catabolic process	IMP IMP: Inferred from mutant phenotype	23502535	GOA
involved in retrograde trans-synaptic signaling by endocannabinoid	IMP IMP: Inferred from mutant phenotype	23502535	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite membrane	IDA IDA: Inferred from direct assay	27595600	GOA
located in early endosome membrane	IDA IDA: Inferred from direct assay	27595600	GOA
located in postsynaptic density membrane	IDA IDA: Inferred from direct assay	27595600	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DAGLA Protein Structure

Lipase_3

0
200
400
600
800
1042 a.a.

Protein Preferred Names

Protein Names

diacylglycerol lipase-alpha

DAGL-alpha

DAGLA Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DAGLA	Q9Y4D2	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	DAGLA	Q9Y4D2	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	DAGLA	Q9Y4D2	UPK1B	Homo sapiens	O75841	Y2H Array	32296183
Intra	DAGLA	Q9Y4D2	UPK1B	Homo sapiens	O75841	Y2H Prey Pooling	32296183
Intra	DAGLA	Q9Y4D2	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	DAGLA	Q9Y4D2	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 20

Spinocerebellar Ataxia Type 20	SCA20
Spinocerebellar Ataxia With Dysphonia	Spinocerebellar Ataxia With Spasmodic Cough
Chromosome 11q12 Duplication Syndrome, 260-Kb	Chromosome 11q12 Duplication Syndrome 260-Kb

Spasmodic Dysphonia

Adductor Spasmodic Dysphonia	Laryngeal Dystonia
Spastic Dysphonia	Abductor Spasmodic Dysphonia
Laryngeal Dyskinesia	Mixed Spasmodic Dysphonia
Abductor Spastic Dysphonia	Adductor Spastic Dysphonia

Cannabis Abuse

Marijuana Abuse

Cannabis Dependence

Marijuana Abuse	Cannabinoid Addiction
Cannabinoid Dependence	Cannabis Addiction

Hallucinogen Dependence

Hallucinogen Addiction

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P4406	Abz-AGLA-Nba		/	Unkown
HY-RS03520	DAGLA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DAGLA	MGD	MGI:2677061
Bos taurus	DAGLA	VGNC	VGNC:27872
Canis familiaris	DAGLA	VGNC	VGNC:39764
Rattus norvegicus	DAGLA	RGD	RGD:1359461
Felis catus	DAGLA	VGNC	VGNC:61332
Macaca mulatta	DAGLA	VGNC	VGNC:107444

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