2. Gene
  3. UPK1B - uroplakin 1B Gene

UPK1B - uroplakin 1B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as UPIB; UPK1; TSPAN20

Gene ID: 7348 | Gene type: protein coding

About UPK1B

Cytogenetic location: 3q13.32 Genomic coordinates (GRCh38): 3:119,173,598-119,205,143 (from NCBI)

This gene has 5 transcripts (splice variants), 136 orthologues and 32 paralogues. Biased expression in urinary bladder (RPKM 15.8), stomach (RPKM 12.4) and 5 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

UPK1B Products(1)

mRNA Protein Name
NM_006952.4 NP_008883.2 uroplakin-1b
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in epithelial cell differentiation IDA
IDA: Inferred from direct assay
10514386 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UPK1B Protein Structure

Tetraspannin

Tetraspannin: Tetraspanin family (10 - 253)

  • 0
  • 100
  • 200
  • 260 a.a.
Protein Preferred Names Protein Names

uroplakin-1b

UP1b

UPK1B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra UPK1B O75841 PIK3IP1 Homo sapiens Q96FE7
Y2H Array
32296183
Intra UPK1B O75841 PIK3IP1 Homo sapiens Q96FE7
Y2H Prey Pooling
32296183
Intra UPK1B O75841 PIK3IP1 Homo sapiens Q96FE7
Validated Y2H
32296183
Intra UPK1B O75841 PLPP4 Homo sapiens Q5VZY2
Y2H Prey Pooling
32296183
Intra UPK1B O75841 PLPP4 Homo sapiens Q5VZY2
Validated Y2H
32296183
Intra UPK1B O75841 PLPP4 Homo sapiens Q5VZY2
Y2H Array
32296183
Intra UPK1B O75841 NEMP1 Homo sapiens O14524-2
Y2H Prey Pooling
32296183
Intra UPK1B O75841 NEMP1 Homo sapiens O14524-2
Y2H Array
32296183
Intra UPK1B O75841 TMEM237 Homo sapiens Q96Q45-2
Validated Y2H
32296183
Intra UPK1B O75841 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra UPK1B O75841 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra UPK1B O75841 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra UPK1B O75841 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra UPK1B O75841 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra UPK1B O75841 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra UPK1B O75841 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra UPK1B O75841 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra UPK1B O75841 KCNJ6 Homo sapiens P48051
Y2H Prey Pooling
32296183
Intra UPK1B O75841 KCNJ6 Homo sapiens P48051
Validated Y2H
32296183
Intra UPK1B O75841 KCNJ6 Homo sapiens P48051
Y2H Array
32296183
Intra UPK1B O75841 SPINT1 Homo sapiens O43278-2
Y2H Array
32296183
Intra UPK1B O75841 SPINT1 Homo sapiens O43278-2
Y2H Prey Pooling
32296183
Intra UPK1B O75841 FNDC9 Homo sapiens Q8TBE3
Validated Y2H
32296183
Intra UPK1B O75841 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra UPK1B O75841 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra UPK1B O75841 ISLR2 Homo sapiens Q6UXK2
Y2H Prey Pooling
32296183
Intra UPK1B O75841 ISLR2 Homo sapiens Q6UXK2
Validated Y2H
32296183
Intra UPK1B O75841 ISLR2 Homo sapiens Q6UXK2
Y2H Array
32296183
Intra UPK1B O75841 DAGLA Homo sapiens Q9Y4D2
Y2H Prey Pooling
32296183
Intra UPK1B O75841 DAGLA Homo sapiens Q9Y4D2
Validated Y2H
32296183
Intra UPK1B O75841 DAGLA Homo sapiens Q9Y4D2
Y2H Array
32296183
Intra UPK1B O75841 MS4A4A Homo sapiens Q96JQ5
Validated Y2H
32296183
Intra UPK1B O75841 MS4A4A Homo sapiens Q96JQ5
Y2H Prey Pooling
32296183
Intra UPK1B O75841 MS4A4A Homo sapiens Q96JQ5
Y2H Array
32296183
Intra UPK1B O75841 SLC39A2 Homo sapiens Q9NP94
Y2H Array
32296183
Intra UPK1B O75841 SLC39A2 Homo sapiens Q9NP94
Y2H Prey Pooling
32296183
Intra UPK1B O75841 SLC39A2 Homo sapiens Q9NP94
Validated Y2H
32296183
Intra UPK1B O75841 EDAR Homo sapiens Q9UNE0-2
Y2H Prey Pooling
32296183
Intra UPK1B O75841 EDAR Homo sapiens Q9UNE0-2
Validated Y2H
32296183
Intra UPK1B O75841 EDAR Homo sapiens Q9UNE0-2
Y2H Array
32296183
Intra UPK1B O75841 TMEM91 Homo sapiens Q6ZNR0-2
Y2H Prey Pooling
32296183
Intra UPK1B O75841 TMEM91 Homo sapiens Q6ZNR0-2
Y2H Array
32296183
Intra UPK1B O75841 TMEM91 Homo sapiens Q6ZNR0-2
Validated Y2H
32296183
Intra UPK1B O75841 RHCG Homo sapiens Q9UBD6
Validated Y2H
32296183
Intra UPK1B O75841 RHCG Homo sapiens Q9UBD6
Y2H Array
32296183
Intra UPK1B O75841 RHCG Homo sapiens Q9UBD6
Y2H Prey Pooling
32296183
Intra UPK1B O75841 SDHAF4 Homo sapiens Q5VUM1
Y2H Array
32296183
Intra UPK1B O75841 SDHAF4 Homo sapiens Q5VUM1
Y2H Prey Pooling
32296183
Intra UPK1B O75841 SDHAF4 Homo sapiens Q5VUM1
Validated Y2H
32296183
Intra UPK1B O75841 TMEM262 Homo sapiens E9PQX1
Y2H Prey Pooling
32296183
Intra UPK1B O75841 TMEM262 Homo sapiens E9PQX1
Y2H Array
32296183
Intra UPK1B O75841 SSMEM1 Homo sapiens Q8WWF3
Validated Y2H
32296183
Intra UPK1B O75841 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra UPK1B O75841 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra UPK1B O75841 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra UPK1B O75841 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra UPK1B O75841 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra UPK1B O75841 GJA8 Homo sapiens P48165
Validated Y2H
32296183
Intra UPK1B O75841 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra UPK1B O75841 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra UPK1B O75841 GJB1 Homo sapiens P08034
Y2H Prey Pooling
32296183
Intra UPK1B O75841 GJB1 Homo sapiens P08034
Validated Y2H
32296183
Intra UPK1B O75841 GJB1 Homo sapiens P08034
Y2H Array
32296183
Intra UPK1B O75841 SHISA4 Homo sapiens Q96DD7
Y2H Prey Pooling
32296183
Intra UPK1B O75841 SHISA4 Homo sapiens Q96DD7
Validated Y2H
32296183
Intra UPK1B O75841 SHISA4 Homo sapiens Q96DD7
Y2H Array
32296183
Intra UPK1B O75841 SLC10A2 Homo sapiens Q12908
Y2H Array
32296183
Intra UPK1B O75841 SLC10A2 Homo sapiens Q12908
Y2H Prey Pooling
32296183
Intra UPK1B O75841 SLC10A2 Homo sapiens Q12908
Validated Y2H
32296183
Intra UPK1B O75841 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra UPK1B O75841 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra UPK1B O75841 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra UPK1B O75841 VSIG1 Homo sapiens Q86XK7
Validated Y2H
32296183
Intra UPK1B O75841 VSIG1 Homo sapiens Q86XK7
Y2H Array
32296183
Intra UPK1B O75841 VSIG1 Homo sapiens Q86XK7
Y2H Prey Pooling
32296183
Intra UPK1B O75841 SYT9 Homo sapiens Q86SS6
Y2H Prey Pooling
32296183
Intra UPK1B O75841 SYT9 Homo sapiens Q86SS6
Validated Y2H
32296183
Intra UPK1B O75841 SYT9 Homo sapiens Q86SS6
Y2H Array
32296183
Intra UPK1B O75841 BEST2 Homo sapiens Q8NFU1
Y2H Prey Pooling
32296183
Intra UPK1B O75841 BEST2 Homo sapiens Q8NFU1
Y2H Array
32296183
Intra UPK1B O75841 BEST2 Homo sapiens Q8NFU1
Validated Y2H
32296183
Intra UPK1B O75841 CERS4 Homo sapiens Q9HA82
Y2H Prey Pooling
32296183
Intra UPK1B O75841 CERS4 Homo sapiens Q9HA82
Validated Y2H
32296183
Intra UPK1B O75841 CERS4 Homo sapiens Q9HA82
Y2H Array
32296183
Intra UPK1B O75841 TMUB2 Homo sapiens Q71RG4
Y2H Array
32296183
Intra UPK1B O75841 TMUB2 Homo sapiens Q71RG4
Validated Y2H
32296183
Intra UPK1B O75841 TMUB2 Homo sapiens Q71RG4
Y2H Prey Pooling
32296183
Intra UPK1B O75841 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra UPK1B O75841 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra UPK1B O75841 CD69 Homo sapiens Q07108
Y2H Array
32296183
Intra UPK1B O75841 CD69 Homo sapiens Q07108
Y2H Prey Pooling
32296183
Intra UPK1B O75841 CD69 Homo sapiens Q07108
Validated Y2H
32296183
Intra UPK1B O75841 GPR37L1 Homo sapiens O60883
Y2H Array
32296183
Intra UPK1B O75841 GPR37L1 Homo sapiens O60883
Y2H Prey Pooling
32296183
Intra UPK1B O75841 ITGB2 Homo sapiens P05107
Validated Y2H
32296183
Intra UPK1B O75841 FKBP7 Homo sapiens Q9Y680
Validated Y2H
32296183
Intra UPK1B O75841 FKBP7 Homo sapiens Q9Y680
Y2H Array
32296183
Intra UPK1B O75841 FKBP7 Homo sapiens Q9Y680
Y2H Prey Pooling
32296183
Intra UPK1B O75841 SAR1A Homo sapiens Q9NR31
Validated Y2H
32296183
Intra UPK1B O75841 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
Intra UPK1B O75841 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
Intra UPK1B O75841 TMEM54 Homo sapiens Q969K7
Validated Y2H
32296183
Intra UPK1B O75841 TMEM45B Homo sapiens Q96B21
Y2H Array
32296183
Intra UPK1B O75841 TMEM45B Homo sapiens Q96B21
Y2H Prey Pooling
32296183
Intra UPK1B O75841 TMEM45B Homo sapiens Q96B21
Validated Y2H
32296183
Intra UPK1B O75841 GPR161 Homo sapiens Q8N6U8
Validated Y2H
32296183
Intra UPK1B O75841 GPR161 Homo sapiens Q8N6U8
Y2H Array
32296183
Intra UPK1B O75841 GPR161 Homo sapiens Q8N6U8
Y2H Prey Pooling
32296183
Intra UPK1B O75841 CD53 Homo sapiens P19397
Y2H Prey Pooling
32296183
Intra UPK1B O75841 CD53 Homo sapiens P19397
Validated Y2H
32296183
Intra UPK1B O75841 CD53 Homo sapiens P19397
Y2H Array
32296183
Intra UPK1B O75841 SIT1 Homo sapiens Q9Y3P8
Y2H Array
32296183
Intra UPK1B O75841 SIT1 Homo sapiens Q9Y3P8
Y2H Prey Pooling
32296183
Intra UPK1B O75841 SIT1 Homo sapiens Q9Y3P8
Validated Y2H
32296183
Intra UPK1B O75841 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra UPK1B O75841 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra UPK1B O75841 STX1A Homo sapiens Q16623
Validated Y2H
32296183
Intra UPK1B O75841 PDZK1IP1 Homo sapiens Q13113
Validated Y2H
32296183
Intra UPK1B O75841 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra UPK1B O75841 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra UPK1B O75841 TMEM139 Homo sapiens Q8IV31
Y2H Array
32296183
Intra UPK1B O75841 TMEM139 Homo sapiens Q8IV31
Y2H Prey Pooling
32296183
Intra UPK1B O75841 TMEM139 Homo sapiens Q8IV31
Validated Y2H
32296183
Intra UPK1B O75841 CLDN7 Homo sapiens O95471
Validated Y2H
32296183
Intra UPK1B O75841 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra UPK1B O75841 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Intra UPK1B O75841 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
32296183
Intra UPK1B O75841 KASH5 Homo sapiens Q8N6L0
Validated Y2H
32296183
Intra UPK1B O75841 KASH5 Homo sapiens Q8N6L0
Y2H Array
32296183
Intra UPK1B O75841 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
Intra UPK1B O75841 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
Intra UPK1B O75841 KIR2DL3 Homo sapiens P43628
Validated Y2H
32296183
Intra UPK1B O75841 KLRC1 Homo sapiens P26715
Y2H Prey Pooling
32296183
Intra UPK1B O75841 KLRC1 Homo sapiens P26715
Validated Y2H
32296183
Intra UPK1B O75841 KLRC1 Homo sapiens P26715
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Transitional Cell Carcinoma

Transitional Cell Neoplasm

Carcinoma, Transitional Cell

Transitional Carcinoma

Transitional Cell Tumor

Urothelial Cell Carcinoma

Carcinoma Transitional Cell

Transitional Cell Carcinoma Of Bladder
Marginal Corneal Ulcer
Fraser Syndrome 1

Fraser Syndrome

Cryptophthalmos With Other Malformations

Cryptophthalmos Syndrome

FRASRS1

Cryptophthalmos-Syndactyly Syndrome

Fraser-Francois Syndrome

Cyclopism

Meyer-Schwickerath'S Syndrome

Ulrich-Feichtiger Syndrome

Cryptophthalmos Syndactyly Syndrome

Fraser'S Syndrome

Meyer-Schwickerath Syndrome

Ullrich-Feichtiger Syndrome
Interstitial Cystitis

Bladder Pain Syndrome

Painful Bladder Syndrome

Ulcerative Cystitis

Ic/Bps

Ic/Pbs

Interstitial Cystitis/Bladder Pain Syndrome

Interstitial Cystitis/Painful Bladder Syndrome

Cystitis, Interstitial

Chronic Interstitial Cystitis

Pelvic Congestion Syndrome

Trigonitis
Cranioectodermal Dysplasia 1

Sensenbrenner Syndrome

CED1

Levin Syndrome I

Cranio-Ectodermal Dysplasia

Dysplasia, Cranioectodermal, Type 1

Cranioectodermal Dysplasia
Bladder Neck Obstruction

Obstruction Of Bladder Neck Or Vesicourethral Orifice

Urinary Bladder Neck Obstruction

Bladder Outlet Obstruction

Vesicourethral Orifice Obstruction

Bno - [Bladder Neck Obstruction]

Bladder Obstruction Nos

Acquired Bladder Neck Obstruction

Acquired Obstruction Of Bladder Neck Or Vesicourethral Orifice

Bladder Neck Strangulation

Bladder Neck Stricture

Bladder Outflow Obstruction

Contracture Of Bladder Neck Or Sphincter

Contracture Of Bladder Neck

Obstructed Vesicourethral Orifice

Strangulation Of Vesicourethral Orifice

Stricture Of Vesicourethral Orifice

Urinary Prostatic Valve Obstruction

Vesical Obstruction
Vesicoureteral Reflux

Vesico-Ureteral Reflux
Hydronephrosis

Stricture Of Ureteropelvic Junction With Hydronephrosis

Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified
Cakut

Renal Or Urinary Tract Malformation

Congenital Anomalies Of Kidney And Urinary Tract

Congenital Anomaly Of Kidney And Urinary Tract

Congenital Anomalies Of The Kidney And Urinary Tract

Kidney And Urinary Tract, Anomalies, Congenital

Renal Hypodysplasia, Nonsyndromic, 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15486 UPK1B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus UPK1B RGD RGD:1307806
Mus musculus UPK1B MGD MGI:98912
Bos taurus UPK1B VGNC VGNC:36685
Macaca mulatta UPK1B VGNC VGNC:110320
Canis familiaris UPK1B VGNC VGNC:48155
Felis catus UPK1B VGNC VGNC:66843