ZNF10 - zinc finger protein 10 Gene

Homo sapiens

Also known as KOX1

Gene ID: 7556 | Gene type: protein coding

About ZNF10

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:133,130,627-133,159,465 (from NCBI)

This gene has 10 transcripts (splice variants), 144 orthologues and 62 paralogues. Broad expression in testis (RPKM 6.7), thyroid (RPKM 5.7) and 25 other tissues.

Summary

The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein. [provided by RefSeq, Jul 2008]

ZNF10 Products(1)

mRNA	Protein	Name
NM_015394.5	NP_056209.2	zinc finger protein 10

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9016654	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	23665872	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	17512541	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF10 Protein Structure

KRAB

zf-H2C2_2

zf-C2H2_6

zf-H2C2_2

zf-C2H2

0
100
200
300
400
500
573 a.a.

Protein Preferred Names

Protein Names

zinc finger protein 10

zinc finger protein 10 (KOX 1)

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16097	ZNF10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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