CARD10 - caspase recruitment domain family member 10 Gene

Homo sapiens

Also known as BIMP1; IMD89; CARMA3

Gene ID: 29775 | Gene type: protein coding

About CARD10

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,490,362-37,519,415 (from NCBI)

This gene has 10 transcripts (splice variants), 217 orthologues, 3 paralogues and is associated with 1 phenotype. Broad expression in small intestine (RPKM 15.9), duodenum (RPKM 15.0) and 22 other tissues.

Summary

The Caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in Apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008]

CARD10 Products(1)

mRNA	Protein	Name
NM_014550.4	NP_055365.2	caspase recruitment domain-containing protein 10

CARD10 Protein Structure

CARD

0
200
400
600
800
1032 a.a.

Protein Preferred Names

Protein Names

caspase recruitment domain-containing protein 10

Bcl10 binding protein and activator of NFKB

Related Diseases

Diseases

Alias

Immunodeficiency 89 And Autoimmunity

IMD89

Glaucoma, Primary Open Angle

Glaucoma 1, Open Angle, E	Primary Open Angle Glaucoma
POAG	Adult-Onset Primary Open Angle Glaucoma
Chronic Simple Glaucoma	GLC1E
Primary Open Angle Glaucoma 1e	Glaucoma, Open Angle, Primary

Immunodeficiency 11

Immunodeficiency 11a	Severe Combined Immunodeficiency Due To Card11 Deficiency
IMD11A	Imd11
Card11 Immunodeficiency	Scid Due To Card11 Deficiency
Card11 Deficiency	Immunodeficiency 11 A

Microcytic Anemia

Iron-Refractory Iron Deficiency Anemia

Pityriasis Rubra Pilaris

PRP	Devergie'S Disease
Prp - [Pityriasis Rubra Pilaris]

Arrhythmogenic Right Ventricular Dysplasia, Familial, 5

Arrhythmogenic Right Ventricular Dysplasia 5	ARVD5
Arrhythmogenic Right Ventricular Cardiomyopathy 5	Arvc5
Familial Arrhythmogenic Right Ventricular Dysplasia 5	Dysplasia, Ventricular, Right, Arrhythmogenic, Type 5

Amelogenesis Imperfecta, Type Ie

Aih1	Amelogenesis Imperfecta Type 1e
AI1E	Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 1
Amelogenesis Imperfecta, Hypomaturation Type, With Snow-Capped Teeth	Enamel Hypoplasia, X-Linked
Amelogenesis Imperfecta Type Ie	Amelogenesis Imperfecta Hypoplastic/Hypomaturation X-Linked 1
Enamel Hypoplasia X-Linked	Amelogenesis Imperfecta, X-Linked 1
Amelogenesis Imperfecta, Type 1e	Amelogenesis Imperfecta Hypomaturationtype With Snow-Capped Teeth
X-Linked Amelogenesis Imperfecta 1	X-Linked Amelogenesis Imperfecta Hypoplastic/Hypomaturation 1
X-Linked Enamel Hypoplasia	Amelogenesis Imperfecta X-Linked 1
Amelogenesis Imperfecta 1e	Amelogenesis Imperfecta, Hypoplastic/Hypomaturation Type 1e
Amelogenesis Imperfecta Hypomaturation Type With Snow-Capped Teeth	Xai
X-Linked Amelogenesis Imperfecta	Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 2

Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma	Gastric Lymphoma, Primary
Lymphoma, Malt, Somatic	Mucosa-Associated Lymphoid Tissue Lymphoma
Extranodal Marginal Zone B-Cell Lymphoma	MALTOMA
Marginal Zone B-Cell Lymphoma	Mucosa-Associated Lymphatic Tissue Lymphoma
Primary Gastric Lymphoma	Gastric Lymphoma
Familial Primary Gastric Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01915	CARD10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CARD10	RGD	RGD:1304949
Mus musculus	CARD10	MGD	MGI:2146012
Canis familiaris	CARD10	VGNC	VGNC:38713
Felis catus	CARD10	VGNC	VGNC:60363
Macaca mulatta	CARD10	VGNC	VGNC:70570
Bos taurus	CARD10	VGNC	VGNC:26760

Name
Email *

	Sorry, but the email address you supplied was invalid.