TMEM50B - transmembrane protein 50B Gene

Homo sapiens

Also known as C21orf4; HCVP7TP3

Gene ID: 757 | Gene type: protein coding

About TMEM50B

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:33,432,486-33,479,974 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 175 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 53.6), gall bladder (RPKM 21.3) and 24 other tissues.

Summary

Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

TMEM50B Products(1)

mRNA	Protein	Name
NM_006134.7	NP_006125.2	transmembrane protein 50B

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM50B Protein Structure

UPF0220

0
100
158 a.a.

Protein Preferred Names

Protein Names

transmembrane protein 50B

HCV p7-trans-regulated protein 3

TMEM50B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TMEM50B	P56557	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	TMEM50B	P56557	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	TMEM50B	P56557	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	TMEM50B	P56557	FXYD3	Homo sapiens	Q14802-3	Y2H Prey Pooling	32296183
Intra	TMEM50B	P56557	FXYD3	Homo sapiens	Q14802-3	Y2H Array	32296183
Intra	TMEM50B	P56557	FXYD3	Homo sapiens	Q14802-3	Validated Y2H	32296183
Intra	TMEM50B	P56557	SLC16A13	Homo sapiens	Q7RTY0	Validated Y2H	32296183
Intra	TMEM50B	P56557	SLC16A13	Homo sapiens	Q7RTY0	Y2H Prey Pooling	32296183
Intra	TMEM50B	P56557	SLC16A13	Homo sapiens	Q7RTY0	Y2H Array	32296183
Intra	TMEM50B	P56557	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	TMEM50B	P56557	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	TMEM50B	P56557	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	TMEM50B	P56557	LEPROT	Homo sapiens	O15243	Y2H Prey Pooling	32296183
Intra	TMEM50B	P56557	TMEM88	Homo sapiens	Q6PEY1	Y2H Array	32296183
Intra	TMEM50B	P56557	TMEM88	Homo sapiens	Q6PEY1	Y2H Prey Pooling	32296183
Intra	TMEM50B	P56557	TMEM88	Homo sapiens	Q6PEY1	Validated Y2H	32296183
Intra	TMEM50B	P56557	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	TMEM50B	P56557	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	TMEM50B	P56557	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	TMEM50B	P56557	CLRN1	Homo sapiens	P58418	Y2H Array	32296183
Intra	TMEM50B	P56557	CLRN1	Homo sapiens	P58418	Y2H Prey Pooling	32296183
Intra	TMEM50B	P56557	CLRN1	Homo sapiens	P58418	Validated Y2H	32296183
Intra	TMEM50B	P56557	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	TMEM50B	P56557	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	TMEM50B	P56557	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	TMEM50B	P56557	HLA-DPA1	Homo sapiens	Q95HB9	Validated Y2H	32296183
Intra	TMEM50B	P56557	HLA-DPA1	Homo sapiens	Q95HB9	Y2H Array	32296183
Intra	TMEM50B	P56557	HLA-DPA1	Homo sapiens	Q95HB9	Y2H Prey Pooling	32296183
Intra	TMEM50B	P56557	SLC10A6	Homo sapiens	Q3KNW5	Validated Y2H	32296183
Intra	TMEM50B	P56557	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	TMEM50B	P56557	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	TMEM50B	P56557	TMEM52B	Homo sapiens	Q4KMG9	Validated Y2H	32296183
Intra	TMEM50B	P56557	TMEM52B	Homo sapiens	Q4KMG9	Y2H Array	32296183
Intra	TMEM50B	P56557	TMEM52B	Homo sapiens	Q4KMG9	Y2H Prey Pooling	32296183
Intra	TMEM50B	P56557	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	TMEM50B	P56557	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	TMEM50B	P56557	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	TMEM50B	P56557	AMIGO1	Homo sapiens	Q86WK6	Y2H Prey Pooling	32296183
Intra	TMEM50B	P56557	AMIGO1	Homo sapiens	Q86WK6	Y2H Array	32296183
Intra	TMEM50B	P56557	AMIGO1	Homo sapiens	Q86WK6	Validated Y2H	32296183
Intra	TMEM50B	P56557	NCR1	Homo sapiens	O76036-6	Y2H Prey Pooling	32296183
Intra	TMEM50B	P56557	NCR1	Homo sapiens	O76036-6	Y2H Array	32296183
Intra	TMEM50B	P56557	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	TMEM50B	P56557	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	TMEM50B	P56557	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	TMEM50B	P56557	EDA	Homo sapiens	Q92838	Y2H Prey Pooling	32296183
Intra	TMEM50B	P56557	EDA	Homo sapiens	Q92838	Validated Y2H	32296183
Intra	TMEM50B	P56557	EDA	Homo sapiens	Q92838	Y2H Array	32296183
Intra	TMEM50B	P56557	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	TMEM50B	P56557	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	TMEM50B	P56557	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	TMEM50B	P56557	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	TMEM50B	P56557	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	TMEM50B	P56557	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	TMEM50B	P56557	BCL2L1	Homo sapiens	Q07817	Validated Y2H	32296183
Intra	TMEM50B	P56557	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	TMEM50B	P56557	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	TMEM50B	P56557	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Immunodeficiency 28

IMD28	Ifngr2 Deficiency
Immunodeficiency 28, Mycobacteriosis, Autosomal Recessive	Immunodeficiency 28, Mycobacteriosis
Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar2 Deficiency	Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 2 Deficiency
Msmd Due To Complete Ifngammar2 Deficiency	Msmd Due To Complete Interferon Gamma Receptor 2 Deficiency
Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar2 Deficiency	Autosomal Recessive Msmd Due To Partial Ifngammar2 Deficiency
Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 2 Deficiency	Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 2 Deficiency
Immunodeficiency, Type 28, Mycobacteriosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14729	TMEM50B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TMEM50B	RGD	RGD:1307561
Felis catus	TMEM50B	VGNC	VGNC:66350
Bos taurus	TMEM50B	VGNC	VGNC:36093
Macaca mulatta	TMEM50B	VGNC	VGNC:84756
Mus musculus	TMEM50B	MGD	MGI:1925225

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