ZKSCAN1 - zinc finger with KRAB and SCAN domains 1 Gene

Homo sapiens

Also known as KOX18; ZNF36; PHZ-37; ZNF139; ZSCAN33

Gene ID: 7586 | Gene type: protein coding

About ZKSCAN1

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,015,596-100,045,374 (from NCBI)

This gene has 6 transcripts (splice variants), 94 orthologues and 31 paralogues. Ubiquitous expression in stomach (RPKM 13.7), skin (RPKM 12.9) and 25 other tissues.

Summary

This gene encodes a member of the Kruppel C2H2-type zinc-finger family of proteins. This encoded protein may function as a transcription factor that regulates the expression of GABA type-A receptors in the brain. Transcripts from this gene have been shown to form stable and abundant circular RNAs. Elevated expression of this gene has been observed in gastric Cancer and the encoded protein may stimulate migration and invasion of human gastric Cancer cells. [provided by RefSeq, Oct 2016]

ZKSCAN1 Products(6)

mRNA	Protein	Name
NM_001287054.3	NP_001273983.1	zinc finger protein with KRAB and SCAN domains 1 isoform b
NM_001287055.3	NP_001273984.1	zinc finger protein with KRAB and SCAN domains 1 isoform c
NM_001346579.2	NP_001333508.1	zinc finger protein with KRAB and SCAN domains 1 isoform d
NM_001346580.2	NP_001333509.1	zinc finger protein with KRAB and SCAN domains 1 isoform b
NM_001346581.2	NP_001333510.1	zinc finger protein with KRAB and SCAN domains 1 isoform a
NM_003439.4	NP_003430.1	zinc finger protein with KRAB and SCAN domains 1 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZKSCAN1 Protein Structure

SCAN

KRAB

zf-H2C2_2

0
100
200
300
400
500
563 a.a.

Protein Preferred Names

Protein Names

zinc finger protein with KRAB and SCAN domains 1

zinc finger protein 139

ZKSCAN1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZKSCAN1	P17029	MAPK7	Homo sapiens	Q13164	Validated Y2H	32296183
Intra	ZKSCAN1	P17029	MAPK7	Homo sapiens	Q13164	Y2H Array	32296183
Intra	ZKSCAN1	P17029	MAPK7	Homo sapiens	Q13164	Y2H Prey Pooling	32296183
Intra	ZKSCAN1	P17029	ZSCAN32	Homo sapiens	Q9NX65	Y2H Prey Pooling	25416956
Intra	ZKSCAN1	P17029	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	ZKSCAN1	P17029	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	ZKSCAN1	P17029	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16081	ZKSCAN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZKSCAN1	VGNC	VGNC:78899
Canis familiaris	ZKSCAN1	VGNC	VGNC:54094
Rattus norvegicus	ZKSCAN1	RGD	RGD:1560616
Mus musculus	ZKSCAN1	MGD	MGI:1921820
Bos taurus	ZKSCAN1	VGNC	VGNC:37188

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