TRIM25 - tripartite motif containing 25 Gene

Homo sapiens

Also known as EFP; Z147; RNF147; ZNF147

Gene ID: 7706 | Gene type: protein coding

About TRIM25

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:56,887,909-56,914,049 (from NCBI)

This gene has 12 transcripts (splice variants), 125 orthologues and 80 paralogues. Ubiquitous expression in bone marrow (RPKM 21.8), skin (RPKM 15.8) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein is an RNA binding protein, functions as a ubiquitin E3 Ligase and is involved in multiple cellular processes, including regulation of Antiviral innate immunity. [provided by RefSeq, Sep 2021]

TRIM25 Products(1)

mRNA	Protein	Name
NM_005082.5	NP_005073.2	E3 ubiquitin/ISG15 ligase TRIM25

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RIG-I binding	IPI IPI: Inferred from physical interaction	23950712	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19454348	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	23077300	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	16352599	GOA
enables ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	24810856	GOA
enables ubiquitin-protein transferase activity	EXP EXP: Inferred from Experiment	17392790	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	24810856	GOA
NOT involved in RIG-I signaling pathway	IMP IMP: Inferred from mutant phenotype	31006531	GOA
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	17392790	GOA
involved in cytoplasmic pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	17392790	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	18248090	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	23077300	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	23077300	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	23077300	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	36075446	GOA
involved in protein monoubiquitination	IMP IMP: Inferred from mutant phenotype	24810856	GOA
involved in regulation of viral entry into host cell	IDA IDA: Inferred from direct assay	18248090	GOA
involved in response to estrogen	IDA IDA: Inferred from direct assay	22452784	GOA
involved in response to oxidative stress	IDA IDA: Inferred from direct assay	36075446	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	22452784	GOA
involved in viral release from host cell	IMP IMP: Inferred from mutant phenotype	18248090	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	23950712	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	23950712	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM25 Protein Structure

zf-C3HC4_4

PRY

SPRY

0
100
200
300
400
500
630 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin/ISG15 ligase TRIM25

RING finger protein 147

TRIM25 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	TRIM25	Q14258	N	SARS-CoV-2	P0DTC9	Anti Tag CoIP	34452305
Cross	TRIM25	Q14258	N	SARS-CoV-2	P0DTC9	Anti Tag CoIP	34471099
Cross	TRIM25	Q14258	NSS	sfts virus hb29	A0A0B5AC19	Confocal	24478431
Intra	TRIM25	Q14258	RIGI	Homo sapiens	O95786	BiFC	24478431
Intra	TRIM25	Q14258	RIGI	Homo sapiens	O95786	Anti Tag CoIP	34452305
Intra	TRIM25	Q14258	RIGI	Homo sapiens	O95786	Anti Tag CoIP	34471099
Intra	TRIM25	Q14258	RIGI	Homo sapiens	O95786	Confocal	34471099
Cross	TRIM25	Q14258	NS	Influenza A virus	P03496	Anti Bait CoIP	19454348
Cross	TRIM25	Q14258	N	Middle East respiratory syndrome-related coronavirus	K9N4V7	Anti Tag CoIP	32295922

Cross: Cross-species interaction Intra: Intraspecies interaction

TRIM25 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82533	TRIM25 Antibody (YA2278)	WB, ICC/IF, IP	Human, Rat

Related Diseases

Diseases

Alias

Middle East Respiratory Syndrome

Mers	Mers - [Middle East Respiratory Syndrome]

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Gingival Recession

Localized Gingival Recession	Gingival Recession, Localized
Minimal Gingival Recession	Moderate Gingival Recession
Severe Gingival Recession	Gingival Recession, Minimal
Gingival Recession, Severe	Atrophy Of Gums
Gum Atrophy	Gingival Atrophy

Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome	Ophthalmoacromelic Syndrome
OAS	MLA
Anophthalmia-Syndactyly	Anophthalmia-Syndactyly Syndrome
Anophthalmos With Limb Anomalies	Anophthalmia Waardenburg Syndrome
Anophthalmos-Syndactyly	Ophthalmo-Acromelic Syndrome
Anophthalmia-Waardenburg Syndrome	Anophthalmos-Limb Anomalies Syndrome
Syndactyly-Anophthalmos Syndrome	Microphthalmia, With Limb Anomalies

Swine Influenza

Influenza Due To Influenza A Virus Subtype H1n1

Gingival Disease

Gingival Diseases	Gum Disease
Gingival Disorder	Gingivitis And Periodontal Diseases

Avian Influenza

Bird Flu	Influenza In Birds
Avian Flu

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-162065	N6F11	Inducer	98.37%	Unkown
HY-RS15030	TRIM25 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TRIM25	VGNC	VGNC:47810
Felis catus	TRIM25	VGNC	VGNC:66531
Macaca mulatta	TRIM25	VGNC	VGNC:78847
Rattus norvegicus	TRIM25	RGD	RGD:1594396
Mus musculus	TRIM25	MGD	MGI:102749
Bos taurus	TRIM25	VGNC	VGNC:36322

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