1. Gene
  2. TRIM25 - tripartite motif containing 25 Gene

TRIM25 - tripartite motif containing 25 Gene

Homo sapiens

Also known as EFP; Z147; RNF147; ZNF147

Gene ID: 7706 | Gene type: protein coding

About TRIM25

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:56,887,909-56,914,049 (from NCBI)

This gene has 12 transcripts (splice variants), 125 orthologues and 80 paralogues. Ubiquitous expression in bone marrow (RPKM 21.8), skin (RPKM 15.8) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein is an RNA binding protein, functions as a ubiquitin E3 Ligase and is involved in multiple cellular processes, including regulation of Antiviral innate immunity. [provided by RefSeq, Sep 2021]

TRIM25 Products(1)

mRNA Protein Name
NM_005082.5 NP_005073.2 E3 ubiquitin/ISG15 ligase TRIM25

TRIM25 Protein Structure

zf-C3HC4_4

zf-C3HC4_4: zinc finger of C3HC4-type, RING (13 - 53)

PRY

PRY: SPRY-associated domain (459 - 504)

SPRY

SPRY: SPRY domain (510 - 621)

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  • 630 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin/ISG15 ligase TRIM25

RING finger protein 147

Related Diseases

Diseases Alias
Middle East Respiratory Syndrome

Mers

Mers - [Middle East Respiratory Syndrome]

Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified

Gingival Recession

Localized Gingival Recession

Gingival Recession, Localized

Minimal Gingival Recession

Moderate Gingival Recession

Severe Gingival Recession

Gingival Recession, Minimal

Gingival Recession, Severe

Atrophy Of Gums

Gum Atrophy

Gingival Atrophy

Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome

Ophthalmoacromelic Syndrome

OAS

MLA

Anophthalmia-Syndactyly

Anophthalmia-Syndactyly Syndrome

Anophthalmos With Limb Anomalies

Anophthalmia Waardenburg Syndrome

Anophthalmos-Syndactyly

Ophthalmo-Acromelic Syndrome

Anophthalmia-Waardenburg Syndrome

Anophthalmos-Limb Anomalies Syndrome

Syndactyly-Anophthalmos Syndrome

Microphthalmia, With Limb Anomalies

Swine Influenza

Influenza Due To Influenza A Virus Subtype H1n1

Gingival Disease

Gingival Diseases

Gum Disease

Gingival Disorder

Gingivitis And Periodontal Diseases

Avian Influenza

Bird Flu

Influenza In Birds

Avian Flu

Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Aicardi-Goutières Syndrome

Encephalopathy With Basal Ganglia Calcification

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris TRIM25 VGNC VGNC:47810
Felis catus TRIM25 VGNC VGNC:66531
Macaca mulatta TRIM25 VGNC VGNC:78847
Rattus norvegicus TRIM25 RGD RGD:1594396
Mus musculus TRIM25 MGD MGI:102749
Bos taurus TRIM25 VGNC VGNC:36322