Shank1 - SH3 and multiple ankyrin repeat domains 1 Gene

Rattus norvegicus

Also known as Spank1; Sstrip; Shank1a

Gene ID: 78957 | Gene type: protein coding

About Shank1

Summary

Enables several functions, including protein C-terminus binding activity; protein domain specific binding activity; and signaling receptor binding activity. Involved in positive regulation of dendritic spine development; protein-containing complex assembly; and synapse maturation. Located in dendritic spine; postsynaptic density; and postsynaptic membrane. Orthologous to human SHANK1 (SH3 and multiple ankyrin repeat domains 1). [provided by Alliance of Genome Resources, Apr 2022]

Shank1 Products(1)

mRNA	Protein	Name
NM_031751.4	NP_113939.2	SH3 and multiple ankyrin repeat domains protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor binding	IPI IPI: Inferred from physical interaction	10958799	RGD
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	15496675	RGD
enables ankyrin repeat binding	IPI IPI: Inferred from physical interaction	15496675	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	15496675	RGD
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	20171009	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10433268	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	11178875	RGD
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	10433269	RGD
enables signaling receptor complex adaptor activity	IDA IDA: Inferred from direct assay	10958799	RGD
enables somatostatin receptor binding	IPI IPI: Inferred from physical interaction	10551867	RGD
enables synaptic receptor adaptor activity	IDA IDA: Inferred from direct assay	10433269	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of dendritic spine development	IDA IDA: Inferred from direct assay	18287537	RGD
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	10433269	RGD
involved in synapse maturation	IDA IDA: Inferred from direct assay	18287537	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendritic spine	IDA IDA: Inferred from direct assay	15496675	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	10433269	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	10958799	RGD
located in synapse	IDA IDA: Inferred from direct assay	15496675	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

SH3 and multiple ankyrin repeat domains protein 1

GKAP/SAPAP-interacting protein	SAPAP-interacting protein synamon
SH3/ankyrin domain gene 1	SPANK-1
SSTR-interacting protein	somatostatin receptor-interacting protein
synamon

Shank1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Shank1	Q9WV48	Sharpin	Rattus norvegicus	Q9EQL9	Confocal	11178875
Intra	Shank1	Q9WV48	Sharpin	Rattus norvegicus	Q9EQL9	Y2H	11178875
Intra	Shank1	Q9WV48	Sharpin	Rattus norvegicus	Q9EQL9	Anti Bait CoIP	11178875
Cross	Shank1	Q9WV48	Grid2	Mus musculus	Q61625	Pull Down	15207857
Intra	Shank1	Q9WV48	Dlg4	Rattus norvegicus	P31016	Anti Bait CoIP	10433268
Intra	Shank1	Q9WV48	Dlgap1	Rattus norvegicus	P97836-5	Pull Down	10433268
Intra	Shank1	Q9WV48	Dlgap1	Rattus norvegicus	P97836-5	Y2H	10433268
Intra	Shank1	Q9WV48	Dlgap1	Rattus norvegicus	P97836	CoIP	10488079
Intra	Shank1	Q9WV48	Dlgap1	Rattus norvegicus	P97836	Anti Bait CoIP	10433268
Cross	Shank1	Q9WV48	Arhgef7	Mus musculus	Q9ES28-2	Pull Down	12626503
Cross	Shank1	Q9WV48	Arhgef7	Mus musculus	Q9ES28-2	Y2H Array	12626503
Cross	Shank1	Q9WV48	Arhgef7	Mus musculus	Q9ES28-2	Anti Tag CoIP	12626503

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12850	SHANK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Shank1	NCBI	NCBI:50944

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