2. Gene
  3. PRR14 - proline rich 14 Gene

PRR14 - proline rich 14 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 78994 | Gene type: protein coding

About PRR14

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,650,778-30,656,413 (from NCBI)

This gene has 13 transcripts (splice variants), 180 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 13.5), bone marrow (RPKM 12.9) and 25 other tissues.

Summary

The protein encoded by this gene tethers heterochromatin to the nuclear laminar scaffold by binding heterochromatin protein 1 (HP1) and the nuclear lamina. The tether is broken during mitosis and reforms quickly after mitosis, with the encoded protein first binding HP1 and then attaching to the nuclear lamina. This protein also has been shown to promote MyoD activity and skeletal myogenesis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2016]

PRR14 Products(2)

mRNA Protein Name
NM_001320464.3 NP_001307393.1 proline-rich protein 14
NM_024031.5 NP_076936.1 proline-rich protein 14
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRR14 Protein Structure

Tantalus

Tantalus: Drosophila Tantalus-like (458 - 517)

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  • 585 a.a.
Protein Preferred Names Protein Names

proline-rich protein 14

PRR14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PRR14 Q9BWN1 CBX3 Homo sapiens Q13185
Anti Tag CoIP
33961781
Intra
PRR14 Q9BWN1 CBX5 Homo sapiens P45973
Anti Tag CoIP
33961781
Intra
PRR14 Q9BWN1 CBX5 Homo sapiens P45973
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11224 PRR14 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PRR14 VGNC VGNC:33391
Macaca mulatta PRR14 VGNC VGNC:76333
Felis catus PRR14 VGNC VGNC:64381
Rattus norvegicus PRR14 RGD RGD:1594592
Canis familiaris PRR14 VGNC VGNC:45038
Mus musculus PRR14 MGD MGI:2384565