AUNIP - aurora kinase A and ninein interacting protein Gene

Homo sapiens

Also known as AIBP; C1orf135

Gene ID: 79000 | Gene type: protein coding

About AUNIP

This gene has 3 transcripts (splice variants) and 91 orthologues. Broad expression in testis (RPKM 11.8), adrenal (RPKM 7.3) and 24 other tissues.

Summary

Enables damaged DNA binding activity. Involved in double-strand break repair via homologous recombination; negative regulation of double-strand break repair via nonhomologous end joining; and spindle organization. Located in centrosome; site of DNA damage; and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]

AUNIP Products(2)

mRNA	Protein	Name
NM_001287490.2	NP_001274419.1	aurora kinase A and ninein-interacting protein isoform 1
NM_024037.3	NP_076942.1	aurora kinase A and ninein-interacting protein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables damaged DNA binding	IDA IDA: Inferred from direct assay	29042561	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20596670	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	29042561	GOA
involved in negative regulation of double-strand break repair via nonhomologous end joining	IDA IDA: Inferred from direct assay	29042561	GOA
involved in spindle organization	IMP IMP: Inferred from mutant phenotype	20596670	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	20596670	GOA
located in site of DNA damage	IDA IDA: Inferred from direct assay	29042561	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	20596670	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AUNIP Protein Structure

AIB

0
100
200
300
357 a.a.

Protein Preferred Names

Protein Names

aurora kinase A and ninein-interacting protein

aurora A-binding protein

AUNIP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	AUNIP	Q9H7T9	GTF3C3	Homo sapiens	Q9Y5Q9	Validated Y2H	32814053
Intra	AUNIP	Q9H7T9	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Array	32814053
Intra	AUNIP	Q9H7T9	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Pooling	32814053
Intra	AUNIP	Q9H7T9	TRIM68	Homo sapiens	Q6AZZ1	Anti Tag CoIP	33961781
Intra	AUNIP	Q9H7T9	TRIM68	Homo sapiens	Q6AZZ1	Anti Tag CoIP	28514442
Intra	AUNIP	Q9H7T9	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	AUNIP	Q9H7T9	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	AUNIP	Q9H7T9	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	AUNIP	Q9H7T9	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	AUNIP	Q9H7T9	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	AUNIP	Q9H7T9	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	AUNIP	Q9H7T9	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	AUNIP	Q9H7T9	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	AUNIP	Q9H7T9	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	AUNIP	Q9H7T9	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	AUNIP	Q9H7T9	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	AUNIP	Q9H7T9	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	AUNIP	Q9H7T9	NXF1	Homo sapiens	Q9UBU9	Validated Y2H	32296183
Intra	AUNIP	Q9H7T9	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183
Intra	AUNIP	Q9H7T9	DR1	Homo sapiens	Q01658	Validated Y2H	32814053
Intra	AUNIP	Q9H7T9	DR1	Homo sapiens	Q01658	Y2H Array	32814053
Intra	AUNIP	Q9H7T9	DR1	Homo sapiens	Q01658	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Breast Apocrine Carcinoma

Apocrine Carcinoma Of Breast

Apocrine Breast Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01264	AUNIP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	AUNIP	MGD	MGI:1917135
Rattus norvegicus	AUNIP	RGD	RGD:1589922
Canis familiaris	AUNIP	VGNC	VGNC:38309
Bos taurus	AUNIP	VGNC	VGNC:26347
Felis catus	AUNIP	VGNC	VGNC:60041
Macaca mulatta	AUNIP	VGNC	VGNC:70140

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