2. Gene
  3. WDR77 - WD repeat domain 77 Gene

WDR77 - WD repeat domain 77 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as p44; MEP50; MEP-50; HKMT1069; Nbla10071; p44/Mep50

Gene ID: 79084 | Gene type: protein coding

About WDR77

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:111,439,890-111,449,256 (from NCBI)

This gene has 4 transcripts (splice variants), 214 orthologues and 9 paralogues. Ubiquitous expression in lymph node (RPKM 14.0), urinary bladder (RPKM 11.8) and 25 other tissues.

Summary

The protein encoded by this gene is an Androgen Receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate Cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in Cancer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

WDR77 Products(4)

mRNA Protein Name
NM_001317062.2 NP_001303991.1 methylosome protein 50 isoform 1
NM_001317063.2 NP_001303992.1 methylosome protein 50 isoform 3
NM_001317064.2 NP_001303993.1 methylosome protein 50 isoform 4
NM_024102.4 NP_077007.1 methylosome protein 50 isoform 2
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables methyl-CpG binding IDA
IDA: Inferred from direct assay
25284789 GOA
enables nuclear receptor coactivator activity IGI
IGI: Inferred from genetic interaction
12972618 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11756452 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19188445 GOA
located in cytoplasm IGI
IGI: Inferred from genetic interaction
12972618 GOA
located in cytosol IDA
IDA: Inferred from direct assay
18984161 GOA
part of methylosome IDA
IDA: Inferred from direct assay
11756452 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21081503 GOA
located in nucleus IGI
IGI: Inferred from genetic interaction
12972618 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR77 Protein Structure

WD40

WD40: WD domain, G-beta repeat (122 - 153)

WD40

WD40: WD domain, G-beta repeat (159 - 196)

WD40

WD40: WD domain, G-beta repeat (247 - 280)

  • 0
  • 100
  • 200
  • 300
  • 342 a.a.
Protein Preferred Names Protein Names

methylosome protein 50

WD repeat-containing protein 77

WDR77 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
WDR77 Q9BQA1 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
WDR77 Q9BQA1 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
WDR77 Q9BQA1 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
WDR77 Q9BQA1 PRMT5 Homo sapiens O14744
Pull Down
11756452
Intra
WDR77 Q9BQA1 PRMT5 Homo sapiens O14744
Anti Bait CoIP
26763441
Intra
WDR77 Q9BQA1 PRMT5 Homo sapiens O14744
Anti Bait CoIP
20951943
Intra
WDR77 Q9BQA1 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra
WDR77 Q9BQA1 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra
WDR77 Q9BQA1 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra
WDR77 Q9BQA1 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra
WDR77 Q9BQA1 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra
WDR77 Q9BQA1 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra
WDR77 Q9BQA1 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
WDR77 Q9BQA1 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
WDR77 Q9BQA1 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant WDR77 Proteins

Cat. No. Product Name Accession Purity
HY-P71622 WDR77 Protein, Human (His-SUMO) Q9BQA1 (1M-312L) ≥95%

WDR77 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80931 WDR77 Antibody (YA655) WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Sarcomatoid Transitional Cell Carcinoma

Transitional Cell Carcinoma, Sarcomatoid

Transitional Spindle Cell Carcinoma

Transitional Cell Carcinoma, Spindle Cell
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15798 WDR77 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta WDR77 VGNC VGNC:79820
Mus musculus WDR77 MGD MGI:1917715
Felis catus WDR77 VGNC VGNC:67056
Rattus norvegicus WDR77 RGD RGD:1310479
Bos taurus WDR77 VGNC VGNC:36921
Others WDR77 NCBI