METTL22 - methyltransferase 22, Kin17 lysine Gene

Homo sapiens

Also known as C16orf68

Gene ID: 79091 | Gene type: protein coding

About METTL22

Cytogenetic location: 16p13.2 Genomic coordinates (GRCh38): 16:8,621,698-8,667,274 (from NCBI)

This gene has 18 transcripts (splice variants) and 187 orthologues. Ubiquitous expression in testis (RPKM 2.7), endometrium (RPKM 1.3) and 25 other tissues.

Summary

This gene encodes a member of the non-histone lysine methyltransferases. It interacts with its substrate, Kin17, which is involved in DNA repair and replication and mRNA processing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

METTL22 Products(1)

mRNA	Protein	Name
NM_024109.4	NP_077014.4	methyltransferase-like protein 22

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	23349634	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23349634	GOA
enables protein methyltransferase activity	IDA IDA: Inferred from direct assay	23349634	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein methylation	IDA IDA: Inferred from direct assay	23349634	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	23349634	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	23349634	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METTL22 Protein Structure

Methyltransf_16

0
100
200
300
404 a.a.

Protein Preferred Names

Protein Names

methyltransferase-like protein 22

LP8272

METTL22 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	METTL22	Q9BUU2	KIN	Homo sapiens	O60870	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Esophageal Atresia/Tracheoesophageal Fistula

Esophageal Atresia And/Or Tracheoesophageal Fistula	Tracheoesophageal Fistula With Or Without Esohageal Atresia
Esophageal Atresia / Tracheoesophageal Fistula	Ea/Tef
Esophageal Atresia With Tracheoesophageal Fistula	Esophageal Atresia With Or Without Tracheoesophageal Fistula

Histidinemia

Histidine Ammonia-Lyase Deficiency	Hal Deficiency
Histidase Deficiency	His Deficiency
Histidinuria	Hyperhistidinemia
HISTID	Histidinuria Renal Tubular Defect

Histidine Metabolism Disease

Disturbances Of Histidine Metabolism	Disorder Of Histidine Metabolism
Disturbance Of Histidine Metabolism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08361	METTL22 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	METTL22	VGNC	VGNC:63462
Canis familiaris	METTL22	VGNC	VGNC:43175
Rattus norvegicus	METTL22	RGD	RGD:1311433
Bos taurus	METTL22	VGNC	VGNC:31408
Mus musculus	METTL22	MGD	MGI:2384301
Macaca mulatta	METTL22	VGNC	VGNC:74602

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