C1orf116 - chromosome 1 open reading frame 116 Gene

Homo sapiens

Also known as SARG

Gene ID: 79098 | Gene type: protein coding

About C1orf116

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:207,018,522-207,032,756 (from NCBI)

This gene has 2 transcripts (splice variants) and 248 orthologues. Biased expression in lung (RPKM 46.8), esophagus (RPKM 46.0) and 10 other tissues.

Summary

Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

C1orf116 Products(2)

mRNA	Protein	Name
NM_001083924.2	NP_001077393.1	specifically androgen-regulated gene protein isoform 2
NM_023938.6	NP_076427.2	specifically androgen-regulated gene protein isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19447967	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15525603	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C1orf116 Protein Structure

SARG

0
100
200
300
400
500
601 a.a.

Protein Preferred Names

Protein Names

specifically androgen-regulated gene protein

specifically androgen-regulated protein

C1orf116 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SARG	Q9BW04	HOMER1	Homo sapiens	Q86YM7	Y2H Prey Pooling	25416956
Intra	SARG	Q9BW04	HOMER1	Homo sapiens	Q86YM7	Y2H Array	25416956
Intra	SARG	Q9BW04	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Fibrosarcomatous Osteosarcoma

Fibroblastic Osteosarcoma

Fibrosarcomatous Osteogenic Sarcoma

Lymph Node Carcinoma

Lymph Node Cancer	Lymph Node Neoplasm
Neoplasm Of Lymph Node

Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma

DMSMFH	Bone Dysplasia With Medullary Fibrosarcoma
Bdmf	Bone Dysplasia With Malignant Fibrous Histiocytoma
Hardcastle Syndrome	Diaphyseal Medullary Stenosis-Bone Malignancy Syndrome
Myopathy, Limb-Girdle, With Bone Fragility	Bone Dysplasia-Medullary Fibrosarcoma Syndrome
Diaphyseal Medullary Stenosis-Malignant Fibrous Histiocytoma Syndrome	Dms-Mfh
Limb-Girdle Myopathy With Bone Fragility	Stenosis, Medullary, Diaphyseal, With Malignant Fibrous Histiocytoma

Meninges Sarcoma

Meningeal Sarcoma	Sarcoma Of Meninges
Meningothelial Sarcoma	Leptomeningeal Sarcoma

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01711	C1orf116 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	C1orf116	RGD	RGD:1565034
Macaca mulatta	C1orf116	VGNC	VGNC:70427
Mus musculus	C1orf116	MGD	MGI:2138143
Bos taurus	C1orf116	VGNC	VGNC:52641

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