HOMER1 - homer scaffold protein 1 Gene

Homo sapiens

Also known as HOMER; SYN47; Ves-1; HOMER1A; HOMER1B; HOMER1C

Gene ID: 9456 | Gene type: protein coding

About HOMER1

Cytogenetic location: 5q14.1 Genomic coordinates (GRCh38): 5:79,372,636-79,514,134 (from NCBI)

This gene has 5 transcripts (splice variants), 268 orthologues and 2 paralogues. Broad expression in brain (RPKM 8.6), thyroid (RPKM 5.8) and 14 other tissues.

Summary

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]

HOMER1 Products(3)

mRNA	Protein	Name
NM_001277077.1	NP_001264006.1	homer protein homolog 1 isoform 2
NM_001277078.1	NP_001264007.1	homer protein homolog 1 isoform 3
NM_004272.5	NP_004263.1	homer protein homolog 1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	14505576	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in response to calcium ion	IDA IDA: Inferred from direct assay	14505576	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOMER1 Protein Structure

WH1

0
100
200
300
354 a.a.

Protein Preferred Names

Protein Names

homer protein homolog 1

homer homolog 1

HOMER1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HOMER1	Q86YM7	ABI1	Homo sapiens	Q8IZP0-5	Y2H Prey Pooling	32296183
Intra	HOMER1	Q86YM7	ABI1	Homo sapiens	Q8IZP0-5	Y2H Array	32296183
Intra	HOMER1	Q86YM7	ABI1	Homo sapiens	Q8IZP0-5	Validated Y2H	32296183
Intra	HOMER1	Q86YM7	SYCE2	Homo sapiens	Q6PIF2	Y2H Prey Pooling	32296183
Intra	HOMER1	Q86YM7	SYCE2	Homo sapiens	Q6PIF2	Y2H Array	32296183
Intra	HOMER1	Q86YM7	SHANK2	Homo sapiens	Q9UPX8-4	Y2H Array	32296183
Intra	HOMER1	Q86YM7	SHANK2	Homo sapiens	Q9UPX8-4	Y2H Prey Pooling	32296183
Intra	HOMER1	Q86YM7	SHANK2	Homo sapiens	Q9UPX8-4	Validated Y2H	32296183
Intra	HOMER1	Q86YM7	INADL	Homo sapiens	A5PKX9	Y2H Prey Pooling	32296183
Intra	HOMER1	Q86YM7	INADL	Homo sapiens	A5PKX9	Y2H Array	32296183
Intra	HOMER1	Q86YM7	AIMP1	Homo sapiens	Q12904-2	Y2H Array	32296183
Intra	HOMER1	Q86YM7	AIMP1	Homo sapiens	Q12904-2	Y2H Prey Pooling	32296183
Intra	HOMER1	Q86YM7	ZMYM5	Homo sapiens	Q9UJ78-2	Y2H Prey Pooling	32296183
Intra	HOMER1	Q86YM7	ZMYM5	Homo sapiens	Q9UJ78-2	Validated Y2H	32296183
Intra	HOMER1	Q86YM7	ZMYM5	Homo sapiens	Q9UJ78-2	Y2H Array	32296183
Intra	HOMER1	Q86YM7	SARG	Homo sapiens	Q9BW04	Y2H Prey Pooling	32296183
Intra	HOMER1	Q86YM7	SARG	Homo sapiens	Q9BW04	Y2H Array	32296183
Intra	HOMER1	Q86YM7	SARG	Homo sapiens	Q9BW04	Y2H Pooling	19447967
Intra	HOMER1	Q86YM7	SARG	Homo sapiens	Q9BW04	Validated Y2H	32296183
Intra	HOMER1	Q86YM7	SARG	Homo sapiens	Q9BW04	Validated Y2H	25416956
Intra	HOMER1	Q86YM7	CENPQ	Homo sapiens	Q7L2Z9	Y2H Array	32296183
Intra	HOMER1	Q86YM7	CENPQ	Homo sapiens	Q7L2Z9	Y2H Prey Pooling	32296183
Intra	HOMER1	Q86YM7	RASAL3	Homo sapiens	Q86YV0	Validated Y2H	32296183
Intra	HOMER1	Q86YM7	RASAL3	Homo sapiens	Q86YV0	Y2H Array	32296183
Intra	HOMER1	Q86YM7	RASAL3	Homo sapiens	Q86YV0	Y2H Prey Pooling	32296183
Intra	HOMER1	Q86YM7	PIAS2	Homo sapiens	O75928-2	Y2H Prey Pooling	32296183
Intra	HOMER1	Q86YM7	PIAS2	Homo sapiens	O75928-2	Y2H Array	32296183
Intra	HOMER1	Q86YM7	TRAF5	Homo sapiens	O00463	Anti Tag CoIP	28514442
Intra	HOMER1	Q86YM7	TRAF5	Homo sapiens	O00463	Anti Tag CoIP	33961781
Intra	HOMER1	Q86YM7	BRME1	Homo sapiens	Q0VDD7	Y2H Prey Pooling	25416956
Intra	HOMER1	Q86YM7	ABI3	Homo sapiens	Q9P2A4	Validated Y2H	32296183
Intra	HOMER1	Q86YM7	HOMER3	Homo sapiens	Q9NSC5	Anti Tag CoIP	35271311
Intra	HOMER1	Q86YM7	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	25416956
Intra	HOMER1	Q86YM7	HOMER3	Homo sapiens	Q9NSC5	Complementation	32296183
Intra	HOMER1	Q86YM7	HOMER3	Homo sapiens	Q9NSC5	Y2H Prey Pooling	25416956
Intra	HOMER1	Q86YM7	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	32296183
Intra	HOMER1	Q86YM7	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	25416956
Intra	HOMER1	Q86YM7	HOMER3	Homo sapiens	Q9NSC5	Y2H Prey Pooling	32296183
Intra	HOMER1	Q86YM7	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	32296183
Intra	HOMER1	Q86YM7	HOMER3	Homo sapiens	Q9NSC5	MAPPIT	25416956
Intra	HOMER1	Q86YM7	HOMER3	Homo sapiens	Q9NSC5	Anti Tag CoIP	25416956
Intra	HOMER1	Q86YM7	FAM9A	Homo sapiens	Q8IZU1	Y2H Prey Pooling	32296183
Intra	HOMER1	Q86YM7	FAM9A	Homo sapiens	Q8IZU1	Validated Y2H	32296183
Intra	HOMER1	Q86YM7	FAM9A	Homo sapiens	Q8IZU1	Y2H Array	32296183
Intra	HOMER1	Q86YM7	RAD54L2	Homo sapiens	Q9Y4B4	Validated Y2H	32296183
Intra	HOMER1	Q86YM7	RAD54L2	Homo sapiens	Q9Y4B4	Y2H Array	32296183
Intra	HOMER1	Q86YM7	RAD54L2	Homo sapiens	Q9Y4B4	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

HOMER1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83290	Homer1 Antibody (YA3035)	WB, IP	Mouse, Rat

Related Diseases

Diseases

Alias

Fragile X Syndrome

FXS	Martin-Bell Syndrome
Fraxa Syndrome	Marker X Syndrome
X-Linked Mental Retardation And Macroorchidism	Fragile X Mental Retardation Syndrome
Fra Syndrome	Mental Retardation, X-Linked, Associated With Marxq28
X-Linked Intellectual Disability And Macroorchidism	Frax Syndrome
Symptomatic Form Of Fragile X Syndrome In Female Carriers	Fragile-X Syndrome
Fraxe Syndrome

Deafness, Autosomal Dominant 68

DFNA68	Autosomal Dominant Nonsyndromic Deafness 68
Autosomal Dominant Deafness 68	Deafness, Autosomal Dominant, 68

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Ogden Syndrome

OGDNS	N-Terminal Acetyltransferase Deficiency
NATD	N-Alpha-Acetyltransferase
X-Linked Malformation And Infantile Lethality Syndrome	Premature Aging Appearance-Developmental Delay-Cardiac Arrhythmia Syndrome

Phelan-Mcdermid Syndrome

Chromosome 22q13.3 Deletion Syndrome	22q13.3 Deletion Syndrome
Telomeric 22q13 Monosomy Syndrome	PHMDS
Deletion 22q13 Syndrome	22q13.3 Deletion
Deletion 22q13.3 Syndrome	Monosomy 22q13
Monosomy 22q13.3	22q13 Deletion Syndrome
Monosomy 22q13 Syndrome	22q13 Deletion
Chromosome Deletion

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Pervasive Developmental Disorder

Pervasive Development Disorder	Pervasive Developmental Disorders
Pervasive Child Development Disorders	Autistic Behavior
Autism Spectrum Disorders

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06283	HOMER1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HOMER1	VGNC	VGNC:73405
Mus musculus	HOMER1	MGD	MGI:1347345
Felis catus	HOMER1	VGNC	VGNC:62830
Canis familiaris	HOMER1	VGNC	VGNC:41737
Rattus norvegicus	HOMER1	RGD	RGD:628725
Bos taurus	HOMER1	VGNC	VGNC:29901

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