IRX6 - iroquois homeobox 6 Gene

Homo sapiens

Also known as IRX7; IRX-3; IRXB3

Gene ID: 79190 | Gene type: protein coding

About IRX6

Cytogenetic location: 16q12.2 Genomic coordinates (GRCh38): 16:55,324,203-55,330,756 (from NCBI)

This gene has 2 transcripts (splice variants), 194 orthologues and 6 paralogues. Biased expression in fat (RPKM 7.9), heart (RPKM 3.1) and 5 other tissues.

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell development; neuron differentiation; and regulation of transcription, DNA-templated. Predicted to act upstream of or within detection of visible light; negative regulation of transcription, DNA-templated; and retina morphogenesis in camera-type eye. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

IRX6 Products(1)

mRNA	Protein	Name
NM_024335.3	NP_077311.2	iroquois-class homeodomain protein IRX-6

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRX6 Protein Structure

Homeobox_KN

0
100
200
300
400
446 a.a.

Protein Preferred Names

Protein Names

iroquois-class homeodomain protein IRX-6

homeodomain protein IRXB3

Related Diseases

Diseases

Alias

Transient Refractive Change

Aniseikonia

Lateral Displacement Of Eye

Lateral Displacement Of Globe

Cycloplegia

Ciliary Muscle Paresis	Cycloplegic Paralysis Of Accommodation
Paresis Of Accommodation	Visual Accommodation Paralysis
Accommodation Paralysis	Intrinsic Paralysis Of Eye Muscle
Cycloplegic

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Eye Accommodation Disease

Cone Dystrophy

Retinal Cone Dystrophy	Dystrophy, Cone
Cone Dystrophy 3

Pulmonary Immaturity

Primary Atelectasis Of Newborn	Primary Atelectasis, In Perinatal Period
Primary Failure To Expand Terminal Respiratory Units	Immature Lungs
Primary Atelectasis	Pulmonary Immaturity Nos
Lung Lobe Hypoplasia, Associated With Short Gestation	Lung Nonexpansion
Premature Lungs	Pulmonary Hypoplasia Associated With Short Gestation
Failure Of Expansion Of Terminal Respiratory Units	Primary Atelectasis Of Fetus Or Newborn
Primary Atelectasis In Perinatal Period

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06925	IRX6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	IRX6	VGNC	VGNC:42103
Mus musculus	IRX6	MGD	MGI:1927642
Macaca mulatta	IRX6	VGNC	VGNC:73598
Rattus norvegicus	IRX6	RGD	RGD:1564830
Felis catus	IRX6	VGNC	VGNC:62973
Bos taurus	IRX6	VGNC	VGNC:30290

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