RTL10 - retrotransposon Gag like 10 Gene

Homo sapiens

Also known as BOP; C22orf29

Gene ID: 79680 | Gene type: protein coding

About RTL10

This gene has 5 transcripts (splice variants), 14 orthologues and 10 paralogues. Ubiquitous expression in skin (RPKM 6.6), brain (RPKM 5.5) and 25 other tissues.

Summary

Involved in mitochondrial outer membrane permeabilization and regulation of mitochondrial membrane potential. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

RTL10 Products(1)

mRNA	Protein	Name
NM_024627.6	NP_078903.3	protein Bop

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23055042	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitochondrial outer membrane permeabilization	IMP IMP: Inferred from mutant phenotype	23055042	GOA
involved in regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	23055042	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	23055042	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein Bop

BH3-only protein

RTL10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RTL10	Q7L3V2	MCL1	Homo sapiens	Q07820	Anti Tag CoIP	23055042
Intra	RTL10	Q7L3V2	BCL2L1	Homo sapiens	Q07817-1	Anti Tag CoIP	23055042
Intra	RTL10	Q7L3V2	GPRASP2	Homo sapiens	Q96D09	BFG-2H	27107012
Intra	RTL10	Q7L3V2	BAX	Homo sapiens	Q07812	Anti Tag CoIP	23055042
Intra	RTL10	Q7L3V2	BAK1	Homo sapiens	Q16611	Anti Tag CoIP	23055042
Intra	RTL10	Q7L3V2	BCL2L2	Homo sapiens	Q92843	Anti Tag CoIP	23055042
Intra	RTL10	Q7L3V2	BCL2L2	Homo sapiens	Q92843	Anti Bait CoIP	23055042

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12323	RTL10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RTL10	MGD	MGI:3833934

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