WDR59 - WD repeat domain 59 Gene

Homo sapiens

Also known as CDW12; FP977; p90-120

Gene ID: 79726 | Gene type: protein coding

About WDR59

Cytogenetic location: 16q23.1 Genomic coordinates (GRCh38): 16:74,871,362-74,985,123 (from NCBI)

This gene has 23 transcripts (splice variants), 199 orthologues and 9 paralogues. Ubiquitous expression in skin (RPKM 11.4), thyroid (RPKM 10.4) and 25 other tissues.

Summary

Involved in cellular response to amino acid starvation and positive regulation of TOR signaling. Located in lysosomal membrane. Part of GATOR2 complex. [provided by Alliance of Genome Resources, Apr 2022]

WDR59 Products(3)

mRNA	Protein	Name
NM_001324171.2	NP_001311100.1	GATOR complex protein WDR59 isoform 2
NM_001324172.2	NP_001311101.1	GATOR complex protein WDR59 isoform 3
NM_030581.4	NP_085058.3	GATOR complex protein WDR59 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25263562	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to amino acid starvation	IMP IMP: Inferred from mutant phenotype	23723238	GOA
involved in cellular response to nutrient levels	IDA IDA: Inferred from direct assay	35831510	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	35831510	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of GATOR2 complex	IDA IDA: Inferred from direct assay	35831510	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	28199306	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR59 Protein Structure

WD40

0
200
400
600
800
974 a.a.

Protein Preferred Names

Protein Names

GATOR complex protein WDR59

CDw12 antigen

WDR59 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	WDR59	Q6PJI9	CASTOR1	Homo sapiens	Q8WTX7	Anti Tag CoIP	26972053
Intra	WDR59	Q6PJI9	CASTOR2	Homo sapiens	A6NHX0	Anti Tag CoIP	26972053
Intra	WDR59	Q6PJI9	YWHAE	Homo sapiens	P62258	Crosslink	36931259

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intermittent Explosive Disorder

Explosive Personality Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15788	WDR59 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	WDR59	RGD	RGD:1592213
Mus musculus	WDR59	MGD	MGI:2442115
Felis catus	WDR59	VGNC	VGNC:67041
Canis familiaris	WDR59	VGNC	VGNC:48376
Macaca mulatta	WDR59	VGNC	VGNC:79531
Bos taurus	WDR59	VGNC	VGNC:36907

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