CASTOR1 - cytosolic arginine sensor for mTORC1 subunit 1 Gene

Homo sapiens

Also known as GATSL3

Gene ID: 652968 | Gene type: protein coding

About CASTOR1

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:30,285,117-30,289,505 (from NCBI)

This gene has 14 transcripts (splice variants), 191 orthologues and 1 paralogue. Broad expression in esophagus (RPKM 13.7), placenta (RPKM 8.5) and 22 other tissues.

Summary

Enables arginine binding activity and identical protein binding activity. Involved in cellular response to L-arginine and negative regulation of TORC1 signaling. Located in cytosol. Colocalizes with GATOR2 complex. [provided by Alliance of Genome Resources, Apr 2022]

CASTOR1 Products(1)

mRNA	Protein	Name
NM_001037666.3	NP_001032755.1	cytosolic arginine sensor for mTORC1 subunit 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables arginine binding	IDA IDA: Inferred from direct assay	26972053	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	26972053	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables molecular sensor activity	IDA IDA: Inferred from direct assay	26972053	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein sequestering activity	IDA IDA: Inferred from direct assay	33594058	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to L-arginine	IDA IDA: Inferred from direct assay	26972053	GOA
involved in cellular response to L-arginine	IMP IMP: Inferred from mutant phenotype	26972053	GOA
involved in cellular response to amino acid starvation	IDA IDA: Inferred from direct assay	26972053	GOA
involved in negative regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	26972053	GOA
involved in negative regulation of TORC1 signaling	IMP IMP: Inferred from mutant phenotype	26972053	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	26972053	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of GATOR2 complex	IDA IDA: Inferred from direct assay	26972053	GOA
located in cytosol	IDA IDA: Inferred from direct assay	26972053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CASTOR1 Protein Structure

ACT_7

0
100
200
300
329 a.a.

Protein Preferred Names

Protein Names

cytosolic arginine sensor for mTORC1 subunit 1

GATS protein like 3

CASTOR1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CASTOR1	Q8WTX7	ZC2HC1A	Homo sapiens	Q96GY0	Anti Tag CoIP	33961781
Intra	CASTOR1	Q8WTX7	ZC2HC1A	Homo sapiens	Q96GY0	Anti Tag CoIP	28514442
Intra	CASTOR1	Q8WTX7	CASTOR2	Homo sapiens	A6NHX0	Anti Tag CoIP	26972053
Intra	CASTOR1	Q8WTX7	CASTOR1	Homo sapiens	Q8WTX7	Anti Tag CoIP	26972053
Intra	CASTOR1	Q8WTX7	ZC2HC1A	Homo sapiens	Q96GY0	Validated Y2H	25416956
Intra	CASTOR1	Q8WTX7	ZC2HC1A	Homo sapiens	Q96GY0	Y2H Prey Pooling	32296183
Intra	CASTOR1	Q8WTX7	CASTOR1	Homo sapiens	Q8WTX7	Y2H Prey Pooling	32296183
Intra	CASTOR1	Q8WTX7	ZC2HC1A	Homo sapiens	Q96GY0	Validated Y2H	32296183
Intra	CASTOR1	Q8WTX7	CASTOR1	Homo sapiens	Q8WTX7	Validated Y2H	32296183
Intra	CASTOR1	Q8WTX7	CASTOR1	Homo sapiens	Q8WTX7	Y2H Array	25416956
Intra	CASTOR1	Q8WTX7	ZC2HC1A	Homo sapiens	Q96GY0	Y2H Array	32296183
Intra	CASTOR1	Q8WTX7	CASTOR1	Homo sapiens	Q8WTX7	Y2H Array	32296183
Intra	CASTOR1	Q8WTX7	TMA16	Homo sapiens	Q96EY4	Y2H Prey Pooling	32296183
Intra	CASTOR1	Q8WTX7	TMA16	Homo sapiens	Q96EY4	Validated Y2H	32296183
Intra	CASTOR1	Q8WTX7	TMA16	Homo sapiens	Q96EY4	Y2H Array	32296183
Intra	CASTOR1	Q8WTX7	CASTOR2	Homo sapiens	A6NHX0	Anti Tag CoIP	33961781
Intra	CASTOR1	Q8WTX7	CASTOR2	Homo sapiens	A6NHX0	Anti Tag CoIP	28514442
Intra	CASTOR1	Q8WTX7	ZC2HC1B	Homo sapiens	Q5TFG8	Y2H Prey Pooling	32296183
Intra	CASTOR1	Q8WTX7	ZC2HC1B	Homo sapiens	Q5TFG8	Y2H Array	32296183
Intra	CASTOR1	Q8WTX7	WDR59	Homo sapiens	Q6PJI9	Anti Tag CoIP	33961781
Intra	CASTOR1	Q8WTX7	WDR59	Homo sapiens	Q6PJI9	Anti Tag CoIP	28514442
Intra	CASTOR1	Q8WTX7	WDR59	Homo sapiens	Q6PJI9	Anti Tag CoIP	26972053
Intra	CASTOR1	Q8WTX7	MIOS	Homo sapiens	Q9NXC5	Anti Tag CoIP	33961781
Intra	CASTOR1	Q8WTX7	MIOS	Homo sapiens	Q9NXC5	Anti Tag CoIP	28514442
Intra	CASTOR1	Q8WTX7	MIOS	Homo sapiens	Q9NXC5	Anti Tag CoIP	26972053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01979	CASTOR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CASTOR1	VGNC	VGNC:38743
Bos taurus	CASTOR1	VGNC	VGNC:26791
Mus musculus	CASTOR1	MGD	MGI:1919212
Rattus norvegicus	CASTOR1	RGD	RGD:1304774
Felis catus	CASTOR1	VGNC	VGNC:80429

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