CASTOR2 - cytosolic arginine sensor for mTORC1 subunit 2 Gene

Homo sapiens

Also known as GATSL1; GATSL2

Gene ID: 729438 | Gene type: protein coding

About CASTOR2

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:74,964,705-75,031,528 (from NCBI)

This gene has 2 transcripts (splice variants), 202 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 6.4), ovary (RPKM 2.5) and 24 other tissues.

Summary

Enables identical protein binding activity. Involved in negative regulation of TORC1 signaling. Located in cytosol. Colocalizes with GATOR2 complex. [provided by Alliance of Genome Resources, Apr 2022]

CASTOR2 Products(1)

mRNA	Protein	Name
NM_001145064.3	NP_001138536.1	cytosolic arginine sensor for mTORC1 subunit 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables arginine binding	IDA IDA: Inferred from direct assay	26972053	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	26972053	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	26972053	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26972053	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of TORC1 signaling	IMP IMP: Inferred from mutant phenotype	26972053	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of GATOR2 complex	IDA IDA: Inferred from direct assay	26972053	GOA
located in cytosol	IDA IDA: Inferred from direct assay	26972053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CASTOR2 Protein Structure

ACT_7

0
100
200
300
329 a.a.

Protein Preferred Names

Protein Names

cytosolic arginine sensor for mTORC1 subunit 2

GATS protein like 2

CASTOR2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CASTOR2	A6NHX0	CASTOR1	Homo sapiens	Q8WTX7	Anti Tag CoIP	26972053
Intra	CASTOR2	A6NHX0	CASTOR2	Homo sapiens	A6NHX0	Anti Tag CoIP	26972053
Intra	CASTOR2	A6NHX0	MIOS	Homo sapiens	Q9NXC5	Anti Tag CoIP	26972053
Intra	CASTOR2	A6NHX0	WDR24	Homo sapiens	Q96S15	Anti Tag CoIP	26972053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spinal Cord Glioma

Glial Tumor Of Spinal Cord	Glial Neoplasm Spinal Cord
Glioma Of Spinal Cord

Spinal Cancer

Spinal Cord Neoplasm	Spinal Cord Neoplasms
Spinal Neoplasms	Intraspinal Tumor
Malignant Tumor Of The Spinal Cord	Spinal Cord Cancer
Spinal Neoplasm	Tumor Of The Spinal Cord
Tumors Spinal Cord	Intraspinal Neoplasm
Spinal Cord--Cancer

Williams-Beuren Syndrome

Williams Syndrome	WBS
Wms	Deletion 7q11.23
Monosomy 7q11.23	Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb
Fanconi Schlesinger Syndrome	Beuren Syndrome
Elfin Facies Syndrome	Elfin Facies With Hypercalcemia
Hypercalcemia-Supravalvar Aortic Stenosis	Ws

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01980	CASTOR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CASTOR2	MGD	MGI:1933384
Rattus norvegicus	CASTOR2	RGD	RGD:1304672

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