ACTR5 - actin related protein 5 Gene

Homo sapiens

Also known as Arp5; INO80M

Gene ID: 79913 | Gene type: protein coding

About ACTR5

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:38,748,460-38,772,520 (from NCBI)

This gene has 1 transcript (splice variant), 196 orthologues and 26 paralogues. Ubiquitous expression in testis (RPKM 7.1), lymph node (RPKM 4.1) and 25 other tissues.

Summary

Involved in UV-damage excision repair and double-strand break repair. Located in cytoplasm and nucleus. Part of Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]

ACTR5 Products(1)

mRNA	Protein	Name
NM_024855.4	NP_079131.3	actin-related protein 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16230350	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in UV-damage excision repair	IMP IMP: Inferred from mutant phenotype	20855601	GOA
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	21303910	GOA
involved in double-strand break repair	IMP IMP: Inferred from mutant phenotype	19014934	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	27641337	GOA
involved in regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	25016522	GOA
involved in regulation of DNA strand elongation	IMP IMP: Inferred from mutant phenotype	25016522	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	26340092	GOA
involved in regulation of chromosome organization	IMP IMP: Inferred from mutant phenotype	26340092	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Ino80 complex	IDA IDA: Inferred from direct assay	18026119	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19014934	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18026119	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACTR5 Protein Structure

Actin

0
100
200
300
400
500
607 a.a.

Protein Preferred Names

Protein Names

actin-related protein 5

ARP5 actin related protein 5 homolog

Related Diseases

Diseases

Alias

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive	Autosomal Recessive Mental Retardation
Autosomal Recessive Non-Syndromic Mental Retardation	Autosomal Recessive Non-Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00233	ACTR5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ACTR5	VGNC	VGNC:25587
Felis catus	ACTR5	VGNC	VGNC:59558
Mus musculus	ACTR5	MGD	MGI:1924748
Rattus norvegicus	ACTR5	RGD	RGD:1307958
Canis familiaris	ACTR5	VGNC	VGNC:37555
Macaca mulatta	ACTR5	VGNC	VGNC:69405

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