WLS - Wnt ligand secretion mediator Gene

Homo sapiens

Also known as EVI; MRP; ZKS; GPR177; mig-14; C1orf139

Gene ID: 79971 | Gene type: protein coding

About WLS

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:68,098,459-68,232,546 (from NCBI)

This gene has 14 transcripts (splice variants), 241 orthologues and is associated with 1 phenotype. Ubiquitous expression in kidney (RPKM 32.7), gall bladder (RPKM 31.7) and 24 other tissues.

Summary

Enables Wnt-protein binding activity and identical protein binding activity. Involved in positive regulation of cell communication and protein transport. Located in several cellular components, including Golgi apparatus; early endosome; and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

WLS Products(3)

mRNA	Protein	Name
NM_001002292.4	NP_001002292.3	protein wntless homolog isoform 2
NM_001193334.1	NP_001180263.1	protein wntless homolog isoform 3
NM_024911.7	NP_079187.3	protein wntless homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Wnt-protein binding	IPI IPI: Inferred from physical interaction	24768165	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	28734904	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18160348	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Wnt protein secretion	IMP IMP: Inferred from mutant phenotype	24768165	GOA
involved in intracellular protein transport	IMP IMP: Inferred from mutant phenotype	16678095	GOA
involved in positive regulation of Wnt protein secretion	IMP IMP: Inferred from mutant phenotype	16678095	GOA
involved in positive regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	16678095	GOA
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	17804805	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	16678095	GOA
located in Golgi membrane	IDA IDA: Inferred from direct assay	24768165	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	16678095	GOA
located in early endosome	IDA IDA: Inferred from direct assay	18160348	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	24768165	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18160348	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	18160348	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WLS Protein Structure

MIG-14_Wnt-bd

0
100
200
300
400
500
541 a.a.

Protein Preferred Names

Protein Names

protein wntless homolog

G protein-coupled receptor 177

Related Diseases

Diseases

Alias

Zaki Syndrome

ZKS	Microcephaly, Progressive, With Developmental Delay, Cupped Ears, And Dysmorphic Features

Volkmann Contracture

Ischemic Contracture

Volkmann'S Ischemic Contracture

Tracheal Disease

Tracheal Diseases	Tracheal Anomaly
Tracheal Disorders

Focal Dermal Hypoplasia

Goltz Syndrome	Goltz-Gorlin Syndrome
FDH	FODH
Dhof	Goltz Gorlin Syndrome
Hypoplasia, Dermal, Focal

Brain Malformations With Or Without Urinary Tract Defects

Chromosome 1p32-P31 Deletion Syndrome	Nfia-Related Disorder
Chromosome 1, Monosomy 1p32	BRMUTD
1p31p32 Microdeletion Syndrome	Nfia Haploinsufficiency
Del(1)(P31p32)	Monosomy 1p31p32
Nfia-Related Disorders

Thyroid Dyshormonogenesis 4

Deiodinase Deficiency	TDH4
Iodotyrosine Dehalogenase Deficiency	Thyroid Hormonogenesis, Genetic Defect In, 4
Hypothyroidism, Congenital, Due To Dyshormonogenesis, 4	Genetic Defect In Thyroid Hormonogenesis 4
Chdh4	Congenital Hypothyroidism Due To Dyshormonogenesis Type 4
Genetic Defect In Thyroid Hormonogenesis Type 4

Tracheomalacia

Congenital Tracheomalacia	Congenital Major Airway Collapse
Tracheomalacia, Congenital	Type 1 Tracheomalacia

Intellectual Disability-Severe Speech Delay-Mild Dysmorphism Syndrome

Foxp1 Syndrome	Mental Retardation With Language Impairment And With Or Without Autistic Features
Foxp1 Related Global Developmental Delay, Intellectual Disability And Speech Defects	Intellectual Disability With Language Impairment And With Or Without Autistic Features

Endosteal Hyperostosis, Autosomal Dominant

Osteosclerosis	Worth Syndrome
Osteosclerosis, Autosomal Dominant	Hyperostosis, Endosteal
Endosteal Hyperostosis, Worth Type	Worth Disease
Autosomal Dominant Endosteal Hyperostosis	Autosomal Dominant Osteosclerosis, Worth Type
Hyperostosis Corticalis Generalisata, Benign Form Of Worth, With Torus Palatinus	Autosomal Dominant Osteosclerosis
Benign Form Of Worth Hyperostosis Corticalis Generalisata With Torus Platinus	Worth'S Syndrome
Worth Type Autosomal Dominant Osteosclerosis	Hyperostosis Corticalis Generalisata, Benign Form Of Worth With Torus Palatinus
Osteosclerosis, Autosomal Dominant, Worth Type	WENHY
Endosteal Hyperostosis Autosomal Dominant	Hyperostosis Corticalis Generalisata Benign Form Of Worth With Torus Palatinus
Osteosclerosis Autosomal Dominant	Acquired Osteosclerosis

Familial Thyroid Dyshormonogenesis

Thyroid Dyshormonogenesis

Familial Dyshormonogenetic Goiter

Tetraamelia Syndrome

Tetra-Amelia Syndrome	Tetraamelia-Multiple Malformations Syndrome
Tetra-Amelia	Tetra-Amelia, Autosomal Recessive
Tetraamelia, Autosomal Recessive	Total Amelia
Zimmer Phocomelia	Tetams
Zimmer Taub Sova Syndrome

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Tooth Agenesis

Oligodontia	Hypodontia
Selective Tooth Agenesis	Tooth Agenesis, Selective
Familial Tooth Agenesis	Anodontia
Congenital Absence Of One Tooth

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15822	WLS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	WLS	RGD	RGD:735139
Canis familiaris	WLS	VGNC	VGNC:48417
Mus musculus	WLS	MGD	MGI:1915401
Macaca mulatta	WLS	VGNC	VGNC:79839
Bos taurus	WLS	VGNC	VGNC:36948
Felis catus	WLS	VGNC	VGNC:67076

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