2. Gene
  3. LRCH4 - leucine rich repeats and calponin homology domain containing 4 Gene

LRCH4 - leucine rich repeats and calponin homology domain containing 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LRN; LRRN1; LRRN4; PP14183

Gene ID: 4034 | Gene type: protein coding

About LRCH4

This gene has 10 transcripts (splice variants), 92 orthologues and 31 paralogues. Broad expression in testis (RPKM 33.5), spleen (RPKM 31.2) and 25 other tissues.

Summary

This gene encodes a protein that contains leucine-rich repeats (LRR) at its amino terminus and that is known to be involved in ligand binding. The carboxyl terminus may act as a membrane anchor. Identified structural elements suggest that the encoded protein resembles a receptor. [provided by RefSeq, Jul 2008]

LRCH4 Products(2)

mRNA Protein Name
NM_001289934.2 NP_001276863.1 leucine-rich repeat and calponin homology domain-containing protein 4 isoform 2
NM_002319.5 NP_002310.2 leucine-rich repeat and calponin homology domain-containing protein 4 isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRCH4 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (74 - 126)

LRR_8

LRR_8: Leucine rich repeat (138 - 194)

LRR_1

LRR_1: Leucine Rich Repeat (206 - 226)

CH

CH: Calponin homology (CH) domain (537 - 630)

  • 0
  • 200
  • 400
  • 600
  • 683 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat and calponin homology domain-containing protein 4

leucine rich repeat neuronal 4

LRCH4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra LRCH4 O75427 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra LRCH4 O75427 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra LRCH4 O75427 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
25416956
Intra LRCH4 O75427 KRTAP10-7 Homo sapiens P60409
Validated Y2H
25416956
Intra LRCH4 O75427 KRTAP10-7 Homo sapiens P60409
Y2H Array
25416956
Intra LRCH4 O75427 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
25416956
Intra LRCH4 O75427 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra LRCH4 O75427 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra LRCH4 O75427 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra LRCH4 O75427 ELOVL7 Homo sapiens A1L3X0
Y2H Array
32296183
Intra LRCH4 O75427 ELOVL7 Homo sapiens A1L3X0
Y2H Prey Pooling
32296183
Intra LRCH4 O75427 CYB5R3 Homo sapiens P00387
Y2H Prey Pooling
32296183
Intra LRCH4 O75427 CYB5R3 Homo sapiens P00387
Validated Y2H
32296183
Intra LRCH4 O75427 CYB5R3 Homo sapiens P00387
Y2H Array
32296183
Intra LRCH4 O75427 HSD17B11 Homo sapiens Q8NBQ5
Y2H Prey Pooling
32296183
Intra LRCH4 O75427 HSD17B11 Homo sapiens Q8NBQ5
Validated Y2H
32296183
Intra LRCH4 O75427 HSD17B11 Homo sapiens Q8NBQ5
Y2H Array
32296183
Intra LRCH4 O75427 RNASEK Homo sapiens Q6P5S7
Y2H Prey Pooling
32296183
Intra LRCH4 O75427 RNASEK Homo sapiens Q6P5S7
Validated Y2H
32296183
Intra LRCH4 O75427 RNASEK Homo sapiens Q6P5S7
Y2H Array
32296183
Intra LRCH4 O75427 DOCK7 Homo sapiens Q96N67
Anti Tag CoIP
24255178
Intra LRCH4 O75427 DOCK8 Homo sapiens Q8NF50-3
Anti Tag CoIP
32203420
Intra LRCH4 O75427 SUGT1 Homo sapiens Q9Y2Z0
Anti Tag CoIP
24255178
Intra LRCH4 O75427 DOCK6 Homo sapiens Q96HP0
Anti Tag CoIP
32203420
Intra LRCH4 O75427 MDFI Homo sapiens Q99750
Y2H Pooling
16189514
Intra LRCH4 O75427 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
32296183
Intra LRCH4 O75427 KASH5 Homo sapiens Q8N6L0
Validated Y2H
32296183
Intra LRCH4 O75427 KASH5 Homo sapiens Q8N6L0
Y2H Array
32296183
Intra LRCH4 O75427 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Brittle Cornea Syndrome 1

Brittle Cornea Syndrome

Fragilitas Oculi With Joint Hyperextensibility

Dysgenesis Mesodermalis Corneae Et Sclerae

BCS1

Corneal Fragility, Keratoglobus, Blue Sclerae, Joint Hyperextensibility

Ehlers-Danlos Syndrome, Type Vib, Formerly

Eds6b, Formerly

Type Vib Ehlers-Danlos Syndrome

Eds Vib

Ehlers-Danlos Syndrome Type 6b

Corneal Fragility Keratoglobus Blue Sclerae Joint Hyperextensibility

Eds6b Formerly

Ehlers-Danlos Syndrome Type Vib Formerly

Ehlers-Danlos Syndrome Type 6

Cornea, Brittle, Syndrome

Cornea, Brittle, Syndrome, Type 1

Ehlers-Danlos Syndrome 6b
Corneal Dystrophy, Posterior Polymorphous, 1

Posterior Polymorphous Corneal Dystrophy

Ppcd

Maumenee Corneal Dystrophy

Posterior Polymorphous Corneal Dystrophy 1

PPCD1

Corneal Dystrophy, Hereditary Polymorphous Posterior

Corneal Endothelial Dystrophy 1, Autosomal Dominant

Schlichting Dystrophy

Ched1

Corneal Endothelial Dystrophy 1, Autosomal Dominant, Formerly

Ched1, Formerly

Hereditary Polymorphus Posterior Corneal Dystrophy

Posterior Polymorphous Dystrophy

Hereditary Polymorphous Posterior Corneal Dystrophy

Dystrophy, Corneal, Posterior Polymorphous

Dystrophy, Corneal, Posterior Polymorphous, Type 1

Polymorphous Corneal Dystrophy

Corneal Endothelial Dystrophy 2
Differentiating Neuroblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07780 LRCH4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LRCH4 RGD RGD:1306145
Bos taurus LRCH4 VGNC VGNC:30974
Macaca mulatta LRCH4 VGNC VGNC:74441
Canis familiaris LRCH4 VGNC VGNC:42759
Mus musculus LRCH4 MGD MGI:1917193
Felis catus LRCH4 VGNC VGNC:68086