EMP3 - epithelial membrane protein 3 Gene

Homo sapiens

Also known as YMP

Gene ID: 2014 | Gene type: protein coding

About EMP3

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,325,552-48,330,553 (from NCBI)

This gene has 9 transcripts (splice variants), 239 orthologues and 10 paralogues. Ubiquitous expression in bone marrow (RPKM 63.7), appendix (RPKM 40.0) and 24 other tissues.

Summary

The protein encoded by this gene belongs to the PMP-22/EMP/MP20 family of proteins. The protein contains four transmembrane domains and two N-linked glycosylation sites. It is thought to be involved in cell proliferation, cell-cell interactions and function as a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

EMP3 Products(2)

mRNA	Protein	Name
NM_001313905.1	NP_001300834.1	epithelial membrane protein 3
NM_001425.3	NP_001416.1	epithelial membrane protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12107182	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in apoptotic process	IDA IDA: Inferred from direct assay	12107182	GOA
involved in bleb assembly	IDA IDA: Inferred from direct assay	12107182	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	12107182	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EMP3 Protein Structure

PMP22_Claudin

0
100
163 a.a.

Protein Preferred Names

Protein Names

epithelial membrane protein 3

EMP-3

EMP3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EMP3	P54852	LDLRAD1	Homo sapiens	Q5T700	Validated Y2H	32296183
Intra	EMP3	P54852	LDLRAD1	Homo sapiens	Q5T700	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	LDLRAD1	Homo sapiens	Q5T700	Y2H Array	32296183
Intra	EMP3	P54852	ELOVL7	Homo sapiens	A1L3X0	Y2H Array	32296183
Intra	EMP3	P54852	ELOVL7	Homo sapiens	A1L3X0	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	LYVE1	Homo sapiens	Q9Y5Y7	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	LYVE1	Homo sapiens	Q9Y5Y7	Validated Y2H	32296183
Intra	EMP3	P54852	LYVE1	Homo sapiens	Q9Y5Y7	Y2H Array	32296183
Intra	EMP3	P54852	RMDN3	Homo sapiens	Q96TC7	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	RMDN3	Homo sapiens	Q96TC7	Y2H Array	32296183
Intra	EMP3	P54852	RMDN3	Homo sapiens	Q96TC7	Validated Y2H	32296183
Intra	EMP3	P54852	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	EMP3	P54852	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	FNDC9	Homo sapiens	Q8TBE3	Validated Y2H	32296183
Intra	EMP3	P54852	MR1	Homo sapiens	Q95460-2	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	MR1	Homo sapiens	Q95460-2	Validated Y2H	32296183
Intra	EMP3	P54852	MR1	Homo sapiens	Q95460-2	Y2H Array	32296183
Intra	EMP3	P54852	MS4A3	Homo sapiens	Q96HJ5	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	MS4A3	Homo sapiens	Q96HJ5	Validated Y2H	32296183
Intra	EMP3	P54852	MS4A3	Homo sapiens	Q96HJ5	Y2H Array	32296183
Intra	EMP3	P54852	OPRM1	Homo sapiens	P35372-10	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	OPRM1	Homo sapiens	P35372-10	Y2H Array	32296183
Intra	EMP3	P54852	GPR61	Homo sapiens	Q9BZJ8	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	GPR61	Homo sapiens	Q9BZJ8	Y2H Array	32296183
Intra	EMP3	P54852	GPR61	Homo sapiens	Q9BZJ8	Validated Y2H	32296183
Intra	EMP3	P54852	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	EMP3	P54852	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	EMP3	P54852	TM4SF18	Homo sapiens	Q96CE8	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	TM4SF18	Homo sapiens	Q96CE8	Validated Y2H	32296183
Intra	EMP3	P54852	TM4SF18	Homo sapiens	Q96CE8	Y2H Array	32296183
Intra	EMP3	P54852	HTATIP2	Homo sapiens	Q9BUP3	Ub Reconstruction	30614533
Intra	EMP3	P54852	HTATIP2	Homo sapiens	Q9BUP3	BiFC	30614533
Intra	EMP3	P54852	HTATIP2	Homo sapiens	Q9BUP3	PLA	30614533
Intra	EMP3	P54852	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	EMP3	P54852	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	KIR3DL3	Homo sapiens	Q8N743	Validated Y2H	32296183
Intra	EMP3	P54852	KIR3DL3	Homo sapiens	Q8N743	Y2H Array	32296183
Intra	EMP3	P54852	KIR3DL3	Homo sapiens	Q8N743	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	EMP3	P54852	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	EMP3	P54852	LEUTX	Homo sapiens	A8MZ59	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	LEUTX	Homo sapiens	A8MZ59	Y2H Array	32296183
Intra	EMP3	P54852	SPACA1	Homo sapiens	Q9HBV2	Validated Y2H	32296183
Intra	EMP3	P54852	SPACA1	Homo sapiens	Q9HBV2	Y2H Array	32296183
Intra	EMP3	P54852	SPACA1	Homo sapiens	Q9HBV2	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	GJB1	Homo sapiens	P08034	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	GJB1	Homo sapiens	P08034	Y2H Array	32296183
Intra	EMP3	P54852	IL3RA	Homo sapiens	P26951	Y2H Array	32296183
Intra	EMP3	P54852	IL3RA	Homo sapiens	P26951	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	SIGLECL1	Homo sapiens	Q8N7X8	Y2H Array	32296183
Intra	EMP3	P54852	SIGLECL1	Homo sapiens	Q8N7X8	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	SIGLECL1	Homo sapiens	Q8N7X8	Validated Y2H	32296183
Intra	EMP3	P54852	SLAMF8	Homo sapiens	Q9P0V8	Validated Y2H	32296183
Intra	EMP3	P54852	SLAMF8	Homo sapiens	Q9P0V8	Y2H Array	32296183
Intra	EMP3	P54852	SLAMF8	Homo sapiens	Q9P0V8	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	VSIG1	Homo sapiens	Q86XK7	Validated Y2H	32296183
Intra	EMP3	P54852	VSIG1	Homo sapiens	Q86XK7	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	VSIG1	Homo sapiens	Q86XK7	Y2H Array	32296183
Intra	EMP3	P54852	FAM210B	Homo sapiens	Q96KR6	Y2H Array	32296183
Intra	EMP3	P54852	FAM210B	Homo sapiens	Q96KR6	Validated Y2H	32296183
Intra	EMP3	P54852	FAM210B	Homo sapiens	Q96KR6	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	TSPAN12	Homo sapiens	O95859	Y2H Array	32296183
Intra	EMP3	P54852	TSPAN12	Homo sapiens	O95859	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	CMTM5	Homo sapiens	Q96DZ9	Ub Reconstruction	30614533
Intra	EMP3	P54852	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	EMP3	P54852	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	EMP3	P54852	SECTM1	Homo sapiens	Q8WVN6	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	SECTM1	Homo sapiens	Q8WVN6	Validated Y2H	32296183
Intra	EMP3	P54852	SECTM1	Homo sapiens	Q8WVN6	Y2H Array	32296183
Intra	EMP3	P54852	PLEKHB2	Homo sapiens	Q96CS7	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	PLEKHB2	Homo sapiens	Q96CS7	Validated Y2H	32296183
Intra	EMP3	P54852	PLEKHB2	Homo sapiens	Q96CS7	Y2H Array	32296183
Intra	EMP3	P54852	IFNGR2	Homo sapiens	P38484	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	IFNGR2	Homo sapiens	P38484	Y2H Array	32296183
Intra	EMP3	P54852	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	SAR1A	Homo sapiens	Q9NR31	Validated Y2H	32296183
Intra	EMP3	P54852	SAR1A	Homo sapiens	Q9NR31	Y2H Array	32296183
Intra	EMP3	P54852	LRRC4C	Homo sapiens	Q9HCJ2	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	LRRC4C	Homo sapiens	Q9HCJ2	Y2H Array	32296183
Intra	EMP3	P54852	LRRC4C	Homo sapiens	Q9HCJ2	Validated Y2H	32296183
Intra	EMP3	P54852	GPA33	Homo sapiens	Q99795	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	GPA33	Homo sapiens	Q99795	Validated Y2H	32296183
Intra	EMP3	P54852	GPA33	Homo sapiens	Q99795	Y2H Array	32296183
Intra	EMP3	P54852	EDA	Homo sapiens	Q92838	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	EDA	Homo sapiens	Q92838	Y2H Array	31515488
Intra	EMP3	P54852	EDA	Homo sapiens	Q92838	Validated Y2H	25416956
Intra	EMP3	P54852	EDA	Homo sapiens	Q92838	Validated Y2H	32296183
Intra	EMP3	P54852	EDA	Homo sapiens	Q92838	Y2H Array	25416956
Intra	EMP3	P54852	EDA	Homo sapiens	Q92838	Y2H Array	32296183
Intra	EMP3	P54852	RAP2A	Homo sapiens	P10114	Ub Reconstruction	30614533
Intra	EMP3	P54852	FLOT1	Homo sapiens	O75955	Ub Reconstruction	30614533
Intra	EMP3	P54852	PLP2	Homo sapiens	Q04941	PLA	30614533
Intra	EMP3	P54852	PLP2	Homo sapiens	Q04941	BiFC	30614533
Intra	EMP3	P54852	PLP2	Homo sapiens	Q04941	Ub Reconstruction	30614533
Intra	EMP3	P54852	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	EMP3	P54852	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	EMP3	P54852	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	EMP3	P54852	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	EMP3	P54852	BSDC1	Homo sapiens	Q9NW68	BiFC	30614533
Intra	EMP3	P54852	BSDC1	Homo sapiens	Q9NW68	Ub Reconstruction	30614533
Intra	EMP3	P54852	BSDC1	Homo sapiens	Q9NW68	PLA	30614533
Intra	EMP3	P54852	VAMP3	Homo sapiens	Q15836	Ub Reconstruction	30614533
Intra	EMP3	P54852	TMEM51	Homo sapiens	Q9NW97	Ub Reconstruction	30614533
Intra	EMP3	P54852	CLDN7	Homo sapiens	O95471	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	CLDN7	Homo sapiens	O95471	Y2H Array	32296183
Intra	EMP3	P54852	SMIM3	Homo sapiens	Q9BZL3	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	SMIM3	Homo sapiens	Q9BZL3	Validated Y2H	32296183
Intra	EMP3	P54852	SMIM3	Homo sapiens	Q9BZL3	Y2H Array	32296183
Intra	EMP3	P54852	GJA5	Homo sapiens	P36382	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	GJA5	Homo sapiens	P36382	Y2H Array	32296183
Intra	EMP3	P54852	CLDN2	Homo sapiens	P57739	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	CLDN2	Homo sapiens	P57739	Validated Y2H	32296183
Intra	EMP3	P54852	CLDN2	Homo sapiens	P57739	Y2H Array	32296183
Intra	EMP3	P54852	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	EMP3	P54852	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	EMP3	P54852	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	EMP3	P54852	SLC30A2	Homo sapiens	Q9BRI3	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	SLC30A2	Homo sapiens	Q9BRI3	Validated Y2H	32296183
Intra	EMP3	P54852	KLRC1	Homo sapiens	P26715	Y2H Prey Pooling	32296183
Intra	EMP3	P54852	KLRC1	Homo sapiens	P26715	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Adult Oligodendroglioma

Adult Brain Oligodendroglioma	Grade Ii Adult Oligodendroglial Tumor
Oligodendroglioma, Adult

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04361	EMP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	EMP3	VGNC	VGNC:40354
Bos taurus	EMP3	VGNC	VGNC:28483
Macaca mulatta	EMP3	VGNC	VGNC:72215
Mus musculus	EMP3	MGD	MGI:1098729
Rattus norvegicus	EMP3	RGD	RGD:621094

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