WWC2 - WW and C2 domain containing 2 Gene

Homo sapiens

Also known as BOMB

Gene ID: 80014 | Gene type: protein coding

About WWC2

Cytogenetic location: 4q35.1 Genomic coordinates (GRCh38): 4:183,099,257-183,320,777 (from NCBI)

This gene has 10 transcripts (splice variants), 162 orthologues and 2 paralogues. Broad expression in lung (RPKM 16.2), kidney (RPKM 8.8) and 23 other tissues.

Summary

This gene encodes a member of the WW-and-C2-domain-containing family of proteins. Members of this family have two N-terminal WW domains that mediate binding to target proteins harboring L/PPxY motifs, an internal C2 domain for membrane association, and C-terminal alpha protein kinase C binding sites and class III PDZ domain-interaction motifs. Proteins of this family are able to form homo- and heterodimers and to modulate hippo pathway signaling. [provided by RefSeq, Sep 2016]

WWC2 Products(2)

mRNA	Protein	Name
NM_001410864.1	NP_001397793.1	protein WWC2 isoform 1
NM_024949.6	NP_079225.5	protein WWC2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables kinase binding	IPI IPI: Inferred from physical interaction	24682284	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	24682284	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15161933	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	35429439	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in hippo signaling	IDA IDA: Inferred from direct assay	35429439	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	24682284	GOA
involved in negative regulation of hippo signaling	IDA IDA: Inferred from direct assay	24682284	GOA
involved in negative regulation of organ growth	IMP IMP: Inferred from mutant phenotype	24682284	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24682284	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	35429439	GOA
located in cytosol	IDA IDA: Inferred from direct assay	24682284	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WWC2 Protein Structure

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1192 a.a.

Protein Preferred Names

Protein Names

protein WWC2

BH3-only member B protein

WWC2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	WWC2	Q6AWC2	YWHAZ	Homo sapiens	P63104	Pull Down	15161933

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15857	WWC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	WWC2	MGD	MGI:1261872
Bos taurus	WWC2	VGNC	VGNC:36975
Felis catus	WWC2	VGNC	VGNC:67097
Rattus norvegicus	WWC2	RGD	RGD:1559427
Canis familiaris	WWC2	VGNC	VGNC:48440
Macaca mulatta	WWC2	VGNC	VGNC:79422

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