2. Gene
  3. NAA50 - N-alpha-acetyltransferase 50, NatE catalytic subunit Gene

NAA50 - N-alpha-acetyltransferase 50, NatE catalytic subunit Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SAN; MAK3; NAT5; NAT13; NAT5P; NAT13P; hNaa50p

Gene ID: 80218 | Gene type: protein coding

About NAA50

Cytogenetic location: 3q13.31 Genomic coordinates (GRCh38): 3:113,716,458-113,746,249 (from NCBI)

This gene has 10 transcripts (splice variants), 246 orthologues and 4 paralogues. Ubiquitous expression in esophagus (RPKM 21.2), fat (RPKM 20.2) and 25 other tissues.

Summary

Enables H4 Histone Acetyltransferase activity; peptide alpha-N-acetyltransferase activity; and peptidyl-lysine acetyltransferase activity. Involved in N-terminal protein amino acid acetylation; establishment of mitotic sister chromatid cohesion; and mitotic sister chromatid cohesion, centromeric. Located in cytosol and nucleus. Part of NatA complex. [provided by Alliance of Genome Resources, Apr 2022]

NAA50 Products(2)

mRNA Protein Name
NM_001308445.2 NP_001295374.1 N-alpha-acetyltransferase 50 isoform 2
NM_025146.4 NP_079422.1 N-alpha-acetyltransferase 50 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables histone H4 acetyltransferase activity IDA
IDA: Inferred from direct assay
19744929 GOA
enables peptide alpha-N-acetyltransferase activity IDA
IDA: Inferred from direct assay
17502424 GOA
enables peptide alpha-N-acetyltransferase activity IMP
IMP: Inferred from mutant phenotype
27422821 GOA
enables peptide-lysine-N-acetyltransferase activity IDA
IDA: Inferred from direct assay
19744929 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16507339 GOA
Biological Process GO Annotation Evidence Reference Source
involved in N-terminal protein amino acid acetylation IDA
IDA: Inferred from direct assay
21900231 GOA
involved in N-terminal protein amino acid acetylation IMP
IMP: Inferred from mutant phenotype
27422821 GOA
involved in establishment of mitotic sister chromatid cohesion IDA
IDA: Inferred from direct assay
27422821 GOA
involved in mitotic sister chromatid cohesion, centromeric IDA
IDA: Inferred from direct assay
17502424 GOA
Cellular Component GO Annotation Evidence Reference Source
part of NatA complex IDA
IDA: Inferred from direct assay
16507339 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
16507339 GOA
located in cytosol IDA
IDA: Inferred from direct assay
27422821 GOA
located in nucleus IDA
IDA: Inferred from direct assay
25732826 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAA50 Protein Structure

Acetyltransf_1

Acetyltransf_1: Acetyltransferase (GNAT) family (50 - 130)

  • 0
  • 100
  • 169 a.a.
Protein Preferred Names Protein Names

N-alpha-acetyltransferase 50

N-acetyltransferase 13 (GCN5-related)

NAA50 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NAA50 Q9GZZ1 NAA15 Homo sapiens Q9BXJ9
Anti Tag CoIP
33961781
Intra
NAA50 Q9GZZ1 NAA15 Homo sapiens Q9BXJ9
Anti Bait CoIP
16507339
Intra
NAA50 Q9GZZ1 NAA15 Homo sapiens Q9BXJ9
Pull Down
16507339
Intra
NAA50 Q9GZZ1 NAA16 Homo sapiens Q6N069
Anti Tag CoIP
33961781
Intra
NAA50 Q9GZZ1 BHLHE40 Homo sapiens O14503
Y2H Prey Pooling
32296183
Intra
NAA50 Q9GZZ1 BHLHE40 Homo sapiens O14503
Validated Y2H
25416956
Intra
NAA50 Q9GZZ1 BHLHE40 Homo sapiens O14503
Y2H Array
32296183
Intra
NAA50 Q9GZZ1 NAA10 Homo sapiens P41227
Pull Down
16507339
Intra
NAA50 Q9GZZ1 NAA10 Homo sapiens P41227
Anti Tag CoIP
33961781
Intra
NAA50 Q9GZZ1 JMJD6 Homo sapiens Q6NYC1
Validated Y2H
25416956
Intra
NAA50 Q9GZZ1 JMJD6 Homo sapiens Q6NYC1
Y2H Prey Pooling
32296183
Intra
NAA50 Q9GZZ1 JMJD6 Homo sapiens Q6NYC1
Y2H Array
32296183
Intra
NAA50 Q9GZZ1 OTX2 Homo sapiens P32243-2
Y2H Prey Pooling
32296183
Intra
NAA50 Q9GZZ1 OTX2 Homo sapiens P32243-2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ogden Syndrome

OGDNS

N-Terminal Acetyltransferase Deficiency

NATD

N-Alpha-Acetyltransferase

X-Linked Malformation And Infantile Lethality Syndrome

Premature Aging Appearance-Developmental Delay-Cardiac Arrhythmia Syndrome
Neurogenic Arthropathy

Neuropathic Arthropathy

Arthropathy Associated With Neurological Disorder

Charcot'S Arthropathy

Charcot'S Joint

Arthropathy, Neurogenic

Charcot Joint

Charcot Or Tabetic Arthropathy

Charcot Foot
Villonodular Synovitis

Pigmented Villonodular Synovitis
Ochronosis
Microphthalmia, Syndromic 1

MCOPS1

Lenz Microphthalmia Syndrome

Lenz Dysplasia

Mcops4

Syndromic Microphthalmia 1

Lenz Microphthalmia

Maa

Microphthalmia Or Anophthalmos With Associated Anomalies

Syndromic Microphthalmia Type 4

Microphthalmia, Syndromic 4

Microphthalmia, Syndromic 4, Formerly

Mcops4, Formerly

Anop1, Formerly

Maa, Formerly

Lenz Type Microphthalmia

Syndromic Microphthalmia 4

Microphthalmia Lenz Type

Microphthalmia Syndromic 1

Syndromic Microphthalmia Type 1

Microphthalmia Syndromic 4

Microphthalmia With Ankyloblepharon And Intellectual Disability

Microphthalmia, Lenz Type

Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome

Microphthalmia, Syndromic, 1

Anop1

Microphthalmia, Syndromic, Type 1
Syndromic Microphthalmia

Microphthalmia, Syndromic
Crouzon Syndrome With Acanthosis Nigricans

Crouzon Syndrome-Acanthosis Nigricans Syndrome

CAN

Crouzonodermoskeletal Syndrome

Crouzon-Dermoskeletal Syndrome

Crouzon, With Acanthosis Nigricans Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-156140 Naa50-IN-1 99.87% Unkown
HY-RS08991 NAA50 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NAA50 VGNC VGNC:96706
Macaca mulatta NAA50 VGNC VGNC:110351
Bos taurus NAA50 VGNC VGNC:53590
Rattus norvegicus NAA50 RGD RGD:1310944
Mus musculus NAA50 MGD MGI:1919367