TASL - TLR adaptor interacting with endolysosomal SLC15A4 Gene

Homo sapiens

Also known as CXorf21

Gene ID: 80231 | Gene type: protein coding

About TASL

Cytogenetic location: Xp21.2 Genomic coordinates (GRCh38): X:30,558,809-30,577,766 (from NCBI)

This gene has 1 transcript (splice variant) and 185 orthologues. Broad expression in appendix (RPKM 6.3), bone marrow (RPKM 6.2) and 17 other tissues.

Summary

Involved in positive regulation of innate immune response; positive regulation of Toll-like Receptor signaling pathway; and regulation of lysosomal lumen pH. Located in endolysosome membrane. [provided by Alliance of Genome Resources, Apr 2022]

TASL Products(1)

mRNA	Protein	Name
NM_025159.3	NP_079435.1	TLR adapter interacting with SLC15A4 on the lysosome

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of innate immune response	IDA IDA: Inferred from direct assay	32433612	GOA
involved in positive regulation of toll-like receptor 7 signaling pathway	IMP IMP: Inferred from mutant phenotype	32433612	GOA
involved in positive regulation of toll-like receptor 8 signaling pathway	IMP IMP: Inferred from mutant phenotype	32433612	GOA
involved in regulation of lysosomal lumen pH	IDA IDA: Inferred from direct assay	31001245	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endolysosome membrane	IDA IDA: Inferred from direct assay	32433612	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TASL Protein Structure

DUF4569

0
100
200
301 a.a.

Protein Preferred Names

Protein Names

TLR adapter interacting with SLC15A4 on the lysosome

5430427O19Rik

TASL Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TASL	Q9HAI6	SLC15A4	Homo sapiens	Q8N697	TAP	32433612
Intra	TASL	Q9HAI6	SLC15A4	Homo sapiens	Q8N697	Anti Tag CoIP	33961781
Intra	TASL	Q9HAI6	SLC15A4	Homo sapiens	Q8N697	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Immunodeficiency 33

IMD33	X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Ikbkg Deficiency
X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Nemo Deficiency	X-Linked Msmd Due To Ikbkg Deficiency
X-Linked Msmd Due To Nemo Deficiency	Invasive Pneumococcal Disease, Recurrent Isolated, 2
Invasive Pneumococcal Disease, Recurrent Isolated, 2, Formerly	Ipd2, Formerly
Nf-Kappa B Essential Modulator Deficiency	Familial X-Linked 1 Atypical Mycobacteriosis
Nemo Deficiency Syndrome	Amcbx1
Familial, X-Linked, Atypical Mycobacteriosis 1	Ipd2
Recurrent Isolated Invasive Pneumococcal Disease 2	X-Linked Disseminated Atypical Mycobacterial Infection Type 1
X-Linked Immunodeficiency 33, Mycobacteriosis	X-Linked Susceptibility To Mycobacterial Disease Type 1
Invasive Pneumococcal Disease, Recurrent Isolated, Type 2	Atypical Mycobacteriosis, Familial, X-Linked 1

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14221	TASL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TASL	VGNC	VGNC:52591
Macaca mulatta	TASL	VGNC	VGNC:71573
Rattus norvegicus	TASL	RGD	RGD:1565785
Mus musculus	TASL	MGD	MGI:1918648
Bos taurus	TASL	VGNC	VGNC:56524
Felis catus	TASL	VGNC	VGNC:61301

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