SLC15A4 - solute carrier family 15 member 4 Gene

Homo sapiens

Also known as PHT1; PTR4; FP12591

Gene ID: 121260 | Gene type: protein coding

About SLC15A4

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:128,793,194-128,823,958 (from NCBI)

This gene has 8 transcripts (splice variants), 204 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 17.6), testis (RPKM 10.0) and 25 other tissues.

Summary

Enables L-histidine transmembrane transporter activity; peptide transmembrane transporter activity; and peptidoglycan transmembrane transporter activity. Involved in several processes, including dipeptide import across plasma membrane; peptidoglycan transport; and positive regulation of Toll-like Receptor signaling pathway. Located in endolysosome membrane. Is integral component of lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC15A4 Products(1)

mRNA	Protein	Name
NM_145648.4	NP_663623.1	solute carrier family 15 member 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-histidine transmembrane transporter activity	IDA IDA: Inferred from direct assay	25238095	GOA
enables dipeptide transmembrane transporter activity	IDA IDA: Inferred from direct assay	29224352	GOA
enables peptide:proton symporter activity	IDA IDA: Inferred from direct assay	25238095	GOA
enables peptidoglycan transmembrane transporter activity	IDA IDA: Inferred from direct assay	25238095	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24695226	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in dipeptide import across plasma membrane	IDA IDA: Inferred from direct assay	29224352	GOA
involved in peptidoglycan transport	IDA IDA: Inferred from direct assay	25238095	GOA
involved in positive regulation of innate immune response	IDA IDA: Inferred from direct assay	32433612	GOA
involved in positive regulation of toll-like receptor 7 signaling pathway	IMP IMP: Inferred from mutant phenotype	25238095	GOA
involved in positive regulation of toll-like receptor 8 signaling pathway	IMP IMP: Inferred from mutant phenotype	32433612	GOA
involved in positive regulation of toll-like receptor 9 signaling pathway	IMP IMP: Inferred from mutant phenotype	25238095	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endolysosome membrane	IDA IDA: Inferred from direct assay	32433612	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	25238095	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC15A4 Protein Structure

PTR2

0
100
200
300
400
500
577 a.a.

Protein Preferred Names

Protein Names

solute carrier family 15 member 4

hPHT1

SLC15A4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLC15A4	Q8N697	TASL	Homo sapiens	Q9HAI6	Anti Bait CoIP	32433612
Intra	SLC15A4	Q8N697	TASL	Homo sapiens	Q9HAI6	Anti Tag CoIP	32433612
Intra	SLC15A4	Q8N697	TASL	Homo sapiens	Q9HAI6	Confocal	32433612
Intra	SLC15A4	Q8N697	TASL	Homo sapiens	Q9HAI6	TAP	32433612
Intra	SLC15A4	Q8N697	NOD2	Homo sapiens	Q9HC29	Anti Tag CoIP	24695226

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hypotrichosis 4

HYPT4	Marie Unna Hereditary Hypotrichosis 1
Muhh1	Hypotrichosis, Marie Unna Type, 1
Hypotrichosis Marie Unna 1	Marie Unna Hereditary Hypotrichosis Type 1
Hypotrichosis, Hereditary, Marie Unna Type, 1	Hypotrichosis, Type 4

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-149652	IRF5-IN-1		99.91%	Unkown
HY-155863	AJ2-71		99.80%	Unkown
HY-RS13015	SLC15A4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SLC15A4	VGNC	VGNC:65203
Macaca mulatta	SLC15A4	VGNC	VGNC:77557
Rattus norvegicus	SLC15A4	RGD	RGD:708469
Mus musculus	SLC15A4	MGD	MGI:2140796
Canis familiaris	SLC15A4	VGNC	VGNC:52967
Bos taurus	SLC15A4	VGNC	VGNC:34681
Others	SLC15A4	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.