2. Gene
  3. SPHKAP - SPHK1 interactor, AKAP domain containing Gene

SPHKAP - SPHK1 interactor, AKAP domain containing Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SKIP

Gene ID: 80309 | Gene type: protein coding

About SPHKAP

Cytogenetic location: 2q36.3 Genomic coordinates (GRCh38): 2:227,979,955-228,181,687 (from NCBI)

This gene has 3 transcripts (splice variants), 197 orthologues and 3 paralogues. Biased expression in heart (RPKM 11.8), brain (RPKM 8.0) and 1 other tissue.

Summary

Enables protein kinase A binding activity. Predicted to be located in Z disc. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

SPHKAP Products(2)

mRNA Protein Name
NM_001142644.2 NP_001136116.1 A-kinase anchor protein SPHKAP isoform 1
NM_030623.4 NP_085126.2 A-kinase anchor protein SPHKAP isoform 2
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12080051 GOA
enables protein kinase A binding IDA
IDA: Inferred from direct assay
20394097 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPHKAP Protein Structure

AKAP_110

AKAP_110: A-kinase anchor protein 110 kDa (AKAP 110) (1594 - 1697)

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  • 1500
  • 1700 a.a.
Protein Preferred Names Protein Names

A-kinase anchor protein SPHKAP

SPHK1 (sphingosine kinase type 1) interacting protein

Related Diseases

Diseases Alias
Cns Neuroblastoma With Foxr2 Activation

Central Nervous System Neuroblastoma With Foxr2 Activation

Cns Nb-Foxr2

Cns Neuroblastoma, Foxr2-Activated
Central Nervous System Neuroblastoma
Central Nervous System Germ Cell Tumor

Central Nervous System Germ Cell Tumour

Germ Cell Tumor Of The Cns

Germ Cell Tumour Of The Cns
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13670 SPHKAP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SPHKAP VGNC VGNC:35212
Canis familiaris SPHKAP VGNC VGNC:46738
Felis catus SPHKAP VGNC VGNC:65636
Rattus norvegicus SPHKAP RGD RGD:1311951
Macaca mulatta SPHKAP VGNC VGNC:78022
Mus musculus SPHKAP MGD MGI:1924879