TET1 - tet methylcytosine dioxygenase 1 Gene

Homo sapiens

Also known as LCX; CXXC6; bA119F7.1

Gene ID: 80312 | Gene type: protein coding

About TET1

Cytogenetic location: 10q21.3 Genomic coordinates (GRCh38): 10:68,560,337-68,694,487 (from NCBI)

This gene has 1 transcript (splice variant), 205 orthologues, 2 paralogues and is associated with 106 phenotypes. Low expression observed in reference dataset.

Summary

DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family. Members of the TET Protein family play a role in the DNA methylation process and gene activation. [provided by RefSeq, Sep 2015]

TET1 Products(12)

mRNA	Protein	Name
NM_001406365.1	NP_001393294.1	methylcytosine dioxygenase TET1 isoform 1
NM_001406367.1	NP_001393296.1	methylcytosine dioxygenase TET1 isoform 3
NM_001406368.1	NP_001393297.1	methylcytosine dioxygenase TET1 isoform 4
NM_001406369.1	NP_001393298.1	methylcytosine dioxygenase TET1 isoform 4
NM_001406370.1	NP_001393299.1	methylcytosine dioxygenase TET1 isoform 4
NM_001406371.1	NP_001393300.1	methylcytosine dioxygenase TET1 isoform 5
NM_001406372.1	NP_001393301.1	methylcytosine dioxygenase TET1 isoform 5
NM_001406373.1	NP_001393302.1	methylcytosine dioxygenase TET1 isoform 6
NM_001406374.1	NP_001393303.1	methylcytosine dioxygenase TET1 isoform 7
NM_001406375.1	NP_001393304.1	methylcytosine dioxygenase TET1 isoform 8
NM_001406376.1	NP_001393305.1	methylcytosine dioxygenase TET1 isoform 9
NM_030625.3	NP_085128.2	methylcytosine dioxygenase TET1 isoform 2

TET1 Protein Structure

zf-CXXC

Tet_JBP

0
400
800
1200
1600
2000
2136 a.a.

Protein Preferred Names

Protein Names

methylcytosine dioxygenase TET1

CXXC finger 6

Related Diseases

Diseases

Alias

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Rett Syndrome

Atypical Rett Syndrome	RTT
Rett Disorder	Rts
Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use	Rett Syndrome, Preserved Speech Variant
Rett Syndrome, Atypical	Rett'S Disorder
Rett Syndrome Variant	Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome
Cerebroatrophic Hyperammonemia	Rett Like Syndrome
Rett'S Syndrome	Atypical Rtt
Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use	Rett Syndrome Preserved Speech Variant
Rett Syndrome Zappella Variant	Rett Syndrome, Zappella Variant

Hypoascorbemia

Scurvy	Ascorbic Acid Deficiency
Vitamin C Deficiency	Vitamin C, Inability To Synthesize
Deficiency Of Vitamin C	Scorbutus
Vitamin C

Chronic Myelomonocytic Leukemia

Leukemia, Myelomonocytic, Chronic	Cmml
Leukemia Myelomonocytic Chronic	Cmml - [Chronic Myelomonocytic Leukaemia]
Chronic Myelomonocytic Leukaemia Without Mention Of Remission	Chronic Monocytic Leukaemia
Chronic Monocytoid Leukaemia

Cartilage-Hair Hypoplasia

Metaphyseal Chondrodysplasia, Mckusick Type	CHH
Mckusick Type Metaphyseal Chondrodysplasia	Metaphyseal Dysplasia Without Hypotrichosis
Cartilage Hair Hypoplasia Like Syndrome	Metaphyseal Chondrodysplasia Mckusick Type
Chhv	Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only
Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency	Cartilage-Hair Syndrome
Mckusick'S Metaphyseal Chondrodysplasia Syndrome	Metaphyseal Chondrodysplasia, Recessive Type
Autosomal Recessive Metaphyseal Chondrodysplasia

Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

Icf Syndrome	Immunodeficiency Syndrome, Variable
Ciid	Centromeric Instability, Immunodeficiency Syndrome
Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16	Icf

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W396714	Succinic acid sodium	Inhibitor	/	Unkown

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111558A	Bobcat339 hydrochloride	Inhibitor	99.59%	Unkown
HY-111558	Bobcat339	Inhibitor	99.73%	Unkown
HY-12303	OAC1	Activator	99.56%	Unkown
HY-122258	NSC-370284	Inhibitor	96.02%	Unkown
HY-120395	UC-514321	Inhibitor	≥98.0%	Unkown
HY-402410	TETi76	Inhibitor	97.49%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TET1	RGD	RGD:1310993
Mus musculus	TET1	MGD	MGI:1098693
Canis familiaris	TET1	VGNC	VGNC:47260
Macaca mulatta	TET1	VGNC	VGNC:79811
Felis catus	TET1	VGNC	VGNC:66092
Bos taurus	TET1	VGNC	VGNC:55994
Others	TET1	NCBI

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