CDK2AP1 - cyclin dependent kinase 2 associated protein 1 Gene

Homo sapiens

Also known as DOC1; ST19; DORC1; doc-1; p12DOC-1

Gene ID: 8099 | Gene type: protein coding

About CDK2AP1

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:123,260,976-123,272,240 (from NCBI)

This gene has 12 transcripts (splice variants), 233 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 57.9), endometrium (RPKM 35.8) and 25 other tissues.

Summary

The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA Polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

CDK2AP1 Products(3)

mRNA	Protein	Name
NM_001270433.2	NP_001257362.1	cyclin-dependent kinase 2-associated protein 1 isoform 2
NM_001270434.2	NP_001257363.1	cyclin-dependent kinase 2-associated protein 1 isoform 2
NM_004642.4	NP_004633.1	cyclin-dependent kinase 2-associated protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA polymerase binding	IPI IPI: Inferred from physical interaction	9506968	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14985111	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	9506968	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20523938	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of NuRD complex	IDA IDA: Inferred from direct assay	20523938	GOA
located in chromatin	IDA IDA: Inferred from direct assay	20523938	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9506968	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	9506968	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK2AP1 Protein Structure

CDK2AP

0
100
115 a.a.

Protein Preferred Names

Protein Names

cyclin-dependent kinase 2-associated protein 1

CDK2-associated protein 1

CDK2AP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CDK2AP1	O14519	CARD9	Homo sapiens	Q9H257-2	Validated Y2H	32296183
Intra	CDK2AP1	O14519	ATPAF2	Homo sapiens	Q8N5M1	Validated Y2H	32296183
Intra	CDK2AP1	O14519	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	CDK2AP1	O14519	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	CDK2AP1	O14519	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	CDK2AP1	O14519	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	CDK2AP1	O14519	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	CDK2AP1	O14519	MRFAP1L1	Homo sapiens	Q96HT8	Validated Y2H	25416956
Intra	CDK2AP1	O14519	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Prey Pooling	32296183
Intra	CDK2AP1	O14519	MRFAP1L1	Homo sapiens	Q96HT8	Validated Y2H	32296183
Intra	CDK2AP1	O14519	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Array	32296183
Intra	CDK2AP1	O14519	MRFAP1L1	Homo sapiens	Q96HT8	Anti Tag CoIP	33961781
Intra	CDK2AP1	O14519	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Campylobacteriosis

Campylobacter Infections	Campylobacter Infection
Enteric Campylobacteriosis

Salmonellosis

Salmonella Infections

Salmonella Infection

Lip And Oral Cavity Cancer

Oral Cancer	Lip And Oral Cavity Carcinoma
Malignant Neoplasm Of Mouth

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02378	CDK2AP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CDK2AP1	VGNC	VGNC:39053
Felis catus	CDK2AP1	VGNC	VGNC:60699
Mus musculus	CDK2AP1	MGD	MGI:1202069
Bos taurus	CDK2AP1	VGNC	VGNC:27125
Macaca mulatta	CDK2AP1	VGNC	VGNC:70944
Rattus norvegicus	CDK2AP1	RGD	RGD:1308664

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