2. Gene
  3. CALU - calumenin Gene

CALU - calumenin Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 813 | Gene type: protein coding

About CALU

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:128,739,359-128,773,400 (from NCBI)

This gene has 6 transcripts (splice variants), 281 orthologues and 4 paralogues. Ubiquitous expression in heart (RPKM 44.6), placenta (RPKM 44.1) and 25 other tissues.

Summary

The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

CALU Products(5)

mRNA Protein Name
NM_001130674.3 NP_001124146.1 calumenin isoform b precursor
NM_001199671.2 NP_001186600.1 calumenin isoform c precursor
NM_001199672.2 NP_001186601.1 calumenin isoform d precursor
NM_001199673.2 NP_001186602.1 calumenin isoform e precursor
NM_001219.5 NP_001210.1 calumenin isoform a precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
10094503 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18688696 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
10222138 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
10222138 GOA
located in extracellular region IDA
IDA: Inferred from direct assay
10222138 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CALU Protein Structure

EF-hand_7

EF-hand_7: EF-hand domain pair (73 - 132)

EF-hand_7

EF-hand_7: EF-hand domain pair (157 - 213)

EF-hand_8

EF-hand_8: EF-hand domain pair (267 - 291)

  • 0
  • 100
  • 200
  • 315 a.a.
Protein Preferred Names Protein Names

calumenin

IEF SSP 9302

CALU Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CALU O43852 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CALU Proteins

Cat. No. Product Name Accession Purity
HY-P7713 Calumenin Protein, Human (HEK293, His) O43852 (K20-F315) ≥95%

CALU Antibodies

Cat. No. Product Name Application Reactivity
HY-P80579 Calumenin Antibody (YA813) WB Human, Mouse

Related Diseases

Diseases Alias
Coumarin Resistance

Warfarin Resistance

Warfarin Sensitivity

Coumadin Sensitivity

Warfarin Response

Poor Metabolism Of Coumarin

Coumarin, Poor Metabolism Of

CMRES
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (18)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-137246 CD73-IN-3 Inhibitor 99.89% Unkown
HY-144269 SHR902275 Inhibitor / Unkown
HY-149304 SARS-CoV-2-IN-40 Inhibitor / Unkown
HY-155014 SARS-CoV-2-IN-44 Inhibitor / Unkown
HY-155015 SARS-CoV-2-IN-45 Inhibitor / Unkown
HY-155016 SARS-CoV-2-IN-46 Inhibitor 99.77% Unkown
HY-156325 SARS-CoV-2-IN-62 Inhibitor / Unkown
HY-156337 SARS-CoV-2-IN-63 Inhibitor / Unkown
HY-156441 SARS-CoV-2-IN-65 Inhibitor / Unkown
HY-162313 NIP-22c Inhibitor / Unkown
HY-162492 Influenza A virus-IN-14 Inhibitor / Unkown
HY-162719 RH12 Inhibitor / Unkown
HY-168660 CPD-10 / Unkown
HY-168664 CPD-39 Degrader / Unkown
HY-RS01849 CALU Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-157805 PROTAC SARS-CoV-2 Mpro degrader-2 Degrader / Unkown
HY-163206 SARS-CoV-2-IN-77 Inhibitor / Unkown
HY-N1107 Uzarigenin / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CALU VGNC VGNC:26717
Macaca mulatta CALU VGNC VGNC:70520
Rattus norvegicus CALU RGD RGD:620383
Mus musculus CALU MGD MGI:1097158
Canis familiaris CALU VGNC VGNC:54755
Felis catus CALU VGNC VGNC:69363
Others CALU NCBI