GRB2 - Grb2 growth factor receptor bound protein 2 Gene

Rattus norvegicus

Also known as Ash-psi

Gene ID: 81504 | Gene type: protein coding

About GRB2

Summary

Enables several functions, including epidermal growth factor receptor binding activity; Insulin Receptor substrate binding activity; and phosphotyrosine residue binding activity. Involved in aging. Part of protein-containing complex. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate Cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2). [provided by Alliance of Genome Resources, Apr 2022]

GRB2 Products(1)

mRNA	Protein	Name
NM_030846.2	NP_110473.2	growth factor receptor-bound protein 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	9259313	RGD
enables epidermal growth factor receptor binding	IPI IPI: Inferred from physical interaction	21258655	RGD
enables insulin receptor substrate binding	IPI IPI: Inferred from physical interaction	12891559	RGD
enables phosphoprotein binding	IPI IPI: Inferred from physical interaction	8910399	RGD
enables phosphotyrosine residue binding	IPI IPI: Inferred from physical interaction	9271418	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8940134	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	10973965	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	15272025	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in presynapse	IDA IDA: Inferred from direct assay	8022809	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	10973965	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

growth factor receptor-bound protein 2

SH2/SH3 adapter GRB2	adapter protein GRB2
growth factor receptor-bound protein 2-like	protein Ash

GRB2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Grb2	P62994	PDE6G	Homo sapiens	P18545	Y2H	16357825
Cross	Grb2	P62994	PTPN1	Homo sapiens	P18031	Pull Down	8940134
Cross	Grb2	P62994	PTPN1	Homo sapiens	P18031	Pull Down	12023880
Intra	Grb2	P62994	Ntrk1	Rattus norvegicus	P35739	Y2H	10748052
Intra	Grb2	P62994	Ntrk1	Rattus norvegicus	P35739	Pull Down	10748052
Intra	Grb2	P62994	Ntrk1	Rattus norvegicus	P35739	CoIP	10748052

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-129800	CGP78850		99.33%	Unkown
HY-RS05780	GRB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	GRB2	NCBI	NCBI:2885

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