MOB2 - MOB kinase activator 2 Gene

Homo sapiens

Also known as HCCA2

Gene ID: 81532 | Gene type: protein coding

About MOB2

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:1,469,448-1,486,779 (from NCBI)

This gene has 6 transcripts (splice variants), 223 orthologues and 6 paralogues. Ubiquitous expression in skin (RPKM 12.1), endometrium (RPKM 11.8) and 25 other tissues.

Summary

Predicted to enable metal ion binding activity. Predicted to act upstream of or within actin Cytoskeleton organization; positive regulation of neuron projection development; and positive regulation of protein phosphorylation. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MOB2 Products(2)

mRNA	Protein	Name
NM_001172223.3	NP_001165694.1	MOB kinase activator 2 isoform 1
NM_053005.5	NP_443731.2	MOB kinase activator 2 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24366813	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MOB2 Protein Structure

Mob1_phocein

0
100
200
268 a.a.

Protein Preferred Names

Protein Names

MOB kinase activator 2

MOB2 Mps One Binder homolog

MOB2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MOB2	Q70IA6	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	MOB2	Q70IA6	RETREG3	Homo sapiens	Q86VR2	Validated Y2H	32296183
Intra	MOB2	Q70IA6	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	MOB2	Q70IA6	FAAP20	Homo sapiens	Q6NZ36-4	Y2H Prey Pooling	32296183
Intra	MOB2	Q70IA6	FAAP20	Homo sapiens	Q6NZ36-4	Y2H Array	32296183
Intra	MOB2	Q70IA6	OR5H1	Homo sapiens	A6NKK0	Y2H Prey Pooling	32296183
Intra	MOB2	Q70IA6	OR5H1	Homo sapiens	A6NKK0	Y2H Array	32296183
Intra	MOB2	Q70IA6	MIIP	Homo sapiens	Q5JXC2	Y2H Prey Pooling	32296183
Intra	MOB2	Q70IA6	MIIP	Homo sapiens	Q5JXC2	Y2H Array	32296183
Intra	MOB2	Q70IA6	SFT2D2	Homo sapiens	O95562	Y2H Prey Pooling	32296183
Intra	MOB2	Q70IA6	SFT2D2	Homo sapiens	O95562	Validated Y2H	32296183
Intra	MOB2	Q70IA6	SFT2D2	Homo sapiens	O95562	Y2H Array	32296183
Intra	MOB2	Q70IA6	STK38	Homo sapiens	Q15208	Anti Tag CoIP	33961781
Intra	MOB2	Q70IA6	FRA10AC1	Homo sapiens	Q70Z53	Y2H Prey Pooling	32296183
Intra	MOB2	Q70IA6	FRA10AC1	Homo sapiens	Q70Z53	Validated Y2H	32296183
Intra	MOB2	Q70IA6	FRA10AC1	Homo sapiens	Q70Z53	Y2H Array	32296183
Intra	MOB2	Q70IA6	CCDC90B	Homo sapiens	Q9GZT6	Validated Y2H	32296183
Intra	MOB2	Q70IA6	CCDC90B	Homo sapiens	Q9GZT6	Y2H Array	32296183
Intra	MOB2	Q70IA6	CCDC90B	Homo sapiens	Q9GZT6	Y2H Prey Pooling	32296183
Intra	MOB2	Q70IA6	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	MOB2	Q70IA6	ATG3	Homo sapiens	Q9NT62	Validated Y2H	32296183
Intra	MOB2	Q70IA6	ATG3	Homo sapiens	Q9NT62	Y2H Array	32296183
Intra	MOB2	Q70IA6	ATG3	Homo sapiens	Q9NT62	Y2H Prey Pooling	32296183
Intra	MOB2	Q70IA6	STK38L	Homo sapiens	Q9Y2H1	Anti Tag CoIP	33961781
Intra	MOB2	Q70IA6	STK38L	Homo sapiens	Q9Y2H1	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Van Maldergem Syndrome

Van Maldergem Wetzburger Verloes Syndrome	Cerebro-Facio-Articular Syndrome
Cerebro-Facio-Articular Syndrome Of Van Maldergem	Cerebrofacioarticular Syndrome
Cerebro Facio Articular Syndrome	Van Maldergem-Wetzburger-Verloes Syndrome

Periventricular Nodular Heterotopia

Periventricular Heterotopia	Pvnh
Familial Nodular Heterotopia	Heterotopia, Periventricular
Periventricular Heterotopia, X-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08575	MOB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MOB2	VGNC	VGNC:101353
Felis catus	MOB2	VGNC	VGNC:63545
Mus musculus	MOB2	MGD	MGI:1919891
Bos taurus	MOB2	VGNC	VGNC:31543
Canis familiaris	MOB2	VGNC	VGNC:43301
Rattus norvegicus	MOB2	RGD	RGD:1562983

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