2. Gene
  3. STK38L - serine/threonine kinase 38 like Gene

STK38L - serine/threonine kinase 38 like Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NDR2

Gene ID: 23012 | Gene type: protein coding

About STK38L

Cytogenetic location: 12p11.23 Genomic coordinates (GRCh38): 12:27,244,286-27,325,959 (from NCBI)

This gene has 13 transcripts (splice variants), 216 orthologues and 1 paralogue. Ubiquitous expression in gall bladder (RPKM 16.1), heart (RPKM 15.2) and 25 other tissues.

Summary

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction. Acts upstream of or within protein phosphorylation. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

STK38L Products(1)

mRNA Protein Name
NM_015000.4 NP_055815.1 serine/threonine-protein kinase 38-like
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATP binding IDA
IDA: Inferred from direct assay
15067004 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
15067004 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15197186 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
15037617 GOA
Biological Process GO Annotation Evidence Reference Source
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
15067004 GOA
involved in negative regulation of autophagy IDA
IDA: Inferred from direct assay
35670107 GOA
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
15037617 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
15067004 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15037617 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STK38L Protein Structure

Pkinase

Pkinase: Protein kinase domain (91 - 383)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (402 - 446)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 464 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase 38-like

NDR2 protein kinase

STK38L Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
STK38L Q9Y2H1 MOB2 Homo sapiens Q70IA6
Y2H Prey Pooling
32296183
Intra
STK38L Q9Y2H1 MOB2 Homo sapiens Q70IA6
Pull Down
30108113
Intra
STK38L Q9Y2H1 MOB2 Homo sapiens Q70IA6
Anti Tag CoIP
24366813
Intra
STK38L Q9Y2H1 MOB2 Homo sapiens Q70IA6
Anti Tag CoIP
35271311
Intra
STK38L Q9Y2H1 MOB2 Homo sapiens Q70IA6
Y2H Array
32296183
Intra
STK38L Q9Y2H1 MOB2 Homo sapiens Q70IA6
Anti Tag CoIP
33961781
Intra
STK38L Q9Y2H1 MOB2 Homo sapiens Q70IA6
Anti Tag CoIP
28514442
Intra
STK38L Q9Y2H1 MOB2 Homo sapiens Q70IA6
Anti Tag CoIP
25852190
Intra
STK38L Q9Y2H1 CDC37 Homo sapiens Q16543
BioID
30108113
Intra
STK38L Q9Y2H1 CDC37 Homo sapiens Q16543
Anti Tag CoIP
24366813
Intra
STK38L Q9Y2H1 CDC37 Homo sapiens Q16543
Pull Down
30108113
Intra
STK38L Q9Y2H1 MOB1A Homo sapiens Q9H8S9
Anti Bait CoIP
17353931
Intra
STK38L Q9Y2H1 MOB1A Homo sapiens Q9H8S9
Anti Tag CoIP
33961781
Intra
STK38L Q9Y2H1 MOB1A Homo sapiens Q9H8S9
Anti Tag CoIP
28514442
Intra
STK38L Q9Y2H1 MOB1A Homo sapiens Q9H8S9
Anti Tag CoIP
25852190
Intra
STK38L Q9Y2H1 MOB1A Homo sapiens Q9H8S9
Anti Tag CoIP
24366813
Intra
STK38L Q9Y2H1 MOB1A Homo sapiens Q9H8S9
Anti Tag CoIP
35271311
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Warburg Micro Syndrome 1

Warburg Micro Syndrome

Micro Syndrome

Warbm

WARBM1

Warburg Sjo Fledelius Syndrome

Warburg-Sjo-Fledelius Syndrome

Micro Syndrome 1

Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism
Ossification Of The Posterior Longitudinal Ligament Of Spine

OPLL

Ossification Of The Posterior Longitudinal Ligament Of The Spine

Ossification Of Posterior Longitudinal Ligament Of Spine

Ossification, Posterior Longitudinal Ligament Spine
Warburg Micro Syndrome 3

WARBM3

Micro Syndrome 3
Warburg Micro Syndrome 2

WARBM2

Micro Syndrome 2
Diffuse Idiopathic Skeletal Hyperostosis

Hyperostosis, Diffuse Idiopathic Skeletal

Ankylosing Vertebral Hyperostosis

Dish

Disseminated Idiopathic Skeletal Hyperostosis

Forestier Disease

Forestier'S Disease

Hyperostosis Diffuse Idiopathic Skeletal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13939 STK38L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus STK38L VGNC VGNC:65787
Macaca mulatta STK38L VGNC VGNC:78156
Rattus norvegicus STK38L RGD RGD:1564793
Canis familiaris STK38L VGNC VGNC:46920
Mus musculus STK38L MGD MGI:1922250
Bos taurus STK38L VGNC VGNC:35400