STK38L - serine/threonine kinase 38 like Gene

Homo sapiens

Also known as NDR2

Gene ID: 23012 | Gene type: protein coding

About STK38L

Cytogenetic location: 12p11.23 Genomic coordinates (GRCh38): 12:27,244,286-27,325,959 (from NCBI)

This gene has 13 transcripts (splice variants), 216 orthologues and 1 paralogue. Ubiquitous expression in gall bladder (RPKM 16.1), heart (RPKM 15.2) and 25 other tissues.

Summary

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction. Acts upstream of or within protein phosphorylation. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

STK38L Products(1)

mRNA	Protein	Name
NM_015000.4	NP_055815.1	serine/threonine-protein kinase 38-like

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	15067004	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	15067004	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15197186	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	15037617	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	15067004	GOA
involved in negative regulation of autophagy	IDA IDA: Inferred from direct assay	35670107	GOA
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	15037617	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	15067004	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15037617	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STK38L Protein Structure

Pkinase

Pkinase_C

0
100
200
300
400
464 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase 38-like

NDR2 protein kinase

STK38L Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	STK38L	Q9Y2H1	MOB2	Homo sapiens	Q70IA6	Y2H Prey Pooling	32296183
Intra	STK38L	Q9Y2H1	MOB2	Homo sapiens	Q70IA6	Pull Down	30108113
Intra	STK38L	Q9Y2H1	MOB2	Homo sapiens	Q70IA6	Anti Tag CoIP	24366813
Intra	STK38L	Q9Y2H1	MOB2	Homo sapiens	Q70IA6	Anti Tag CoIP	35271311
Intra	STK38L	Q9Y2H1	MOB2	Homo sapiens	Q70IA6	Y2H Array	32296183
Intra	STK38L	Q9Y2H1	MOB2	Homo sapiens	Q70IA6	Anti Tag CoIP	33961781
Intra	STK38L	Q9Y2H1	MOB2	Homo sapiens	Q70IA6	Anti Tag CoIP	28514442
Intra	STK38L	Q9Y2H1	MOB2	Homo sapiens	Q70IA6	Anti Tag CoIP	25852190
Intra	STK38L	Q9Y2H1	CDC37	Homo sapiens	Q16543	BioID	30108113
Intra	STK38L	Q9Y2H1	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	24366813
Intra	STK38L	Q9Y2H1	CDC37	Homo sapiens	Q16543	Pull Down	30108113
Intra	STK38L	Q9Y2H1	MOB1A	Homo sapiens	Q9H8S9	Anti Bait CoIP	17353931
Intra	STK38L	Q9Y2H1	MOB1A	Homo sapiens	Q9H8S9	Anti Tag CoIP	33961781
Intra	STK38L	Q9Y2H1	MOB1A	Homo sapiens	Q9H8S9	Anti Tag CoIP	28514442
Intra	STK38L	Q9Y2H1	MOB1A	Homo sapiens	Q9H8S9	Anti Tag CoIP	25852190
Intra	STK38L	Q9Y2H1	MOB1A	Homo sapiens	Q9H8S9	Anti Tag CoIP	24366813
Intra	STK38L	Q9Y2H1	MOB1A	Homo sapiens	Q9H8S9	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Warburg Micro Syndrome 1

Warburg Micro Syndrome	Micro Syndrome
Warbm	WARBM1
Warburg Sjo Fledelius Syndrome	Warburg-Sjo-Fledelius Syndrome
Micro Syndrome 1	Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism

Ossification Of The Posterior Longitudinal Ligament Of Spine

OPLL	Ossification Of The Posterior Longitudinal Ligament Of The Spine
Ossification Of Posterior Longitudinal Ligament Of Spine	Ossification, Posterior Longitudinal Ligament Spine

Warburg Micro Syndrome 3

WARBM3

Micro Syndrome 3

Warburg Micro Syndrome 2

WARBM2

Micro Syndrome 2

Diffuse Idiopathic Skeletal Hyperostosis

Hyperostosis, Diffuse Idiopathic Skeletal	Ankylosing Vertebral Hyperostosis
Dish	Disseminated Idiopathic Skeletal Hyperostosis
Forestier Disease	Forestier'S Disease
Hyperostosis Diffuse Idiopathic Skeletal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13939	STK38L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	STK38L	VGNC	VGNC:65787
Macaca mulatta	STK38L	VGNC	VGNC:78156
Rattus norvegicus	STK38L	RGD	RGD:1564793
Canis familiaris	STK38L	VGNC	VGNC:46920
Mus musculus	STK38L	MGD	MGI:1922250
Bos taurus	STK38L	VGNC	VGNC:35400

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